New Perspectives on the Potential Role of Aquaporins (AQPs) in the Physiology of Inflammation

Meli, Rosaria; Pirozzi, Claudio; Pelagalli, Alessandra

doi:10.3389/fphys.2018.00101

Cited by 127 publications

(93 citation statements)

References 115 publications

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“…Accumulating studies have highlighted that cytokines, including TNF, IL-6, and interferon-g, are associated with severity of inflammation (10,25,26). We showed in this study that lower serum levels of the proinflammatory cytokines, TNF, and IL-6, and a lesser degree of inflammatory cell infiltration into colon tissues were observed in AQP4 2/2 mice compared with AQP4 wt mice after DSS treatment.…”

Section: Discussionsupporting

confidence: 55%

“…AQP4 plays an important role in regulating brain edema and development of astrocytoma in the human CNS. A growing body of evidence supports the role of AQP4, which is abundantly expressed in the basolateral membrane of colonic epithelial cells in humans and mice, in colonic inflammation (7,10). However, the specific mechanistic role of AQP4 in UC remains unclear and controversial (11)(12)(13).…”

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confidence: 99%

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Aquaporin 4 deficiency alleviates experimental colitis in mice

et al. 2019

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Aquaporin (AQP) 4 is expressed in the basolateral membrane of colonic epithelial cells, and the purpose of this study was to explore the mechanistic role of AQP4 in experimental colitis. Experimental colitis was induced in AQP4 knockout (AQP4−/−) CD‐1 mice and AQP4 wild‐type (AQP4wt) mice by oral administration of dextran sulfate sodium (DSS). Experimental colitis was clinically established. Compared with AQP4wt mice, AQP4−/− mice showed increased tolerance to DSS‐induced experimental colitis, including lesser degree of weight loss, diarrhea and bleeding, lower disease activity index scores, longer colon lengths, and lesser histologic scores. DSS‐treated AQP4−/− mice had lower serum levels of IL‐6 and TNF, higher IL‐10 level, and lesser inflammatory cell infiltration. DSS‐treated AQP4−/− mice also had lower immunostaining of NF‐κB p65 as well as nuclear levels of p65 and phosphorylated p65. Sequencing of 16S rRNA indicated that DSS‐treated AQP4−/− mice maintained intestinal microbial diversity and had higher Firmicutes/Bacteroidetes ratios and greater relative abundance of Erysipelotrichaceae species. These results suggested for the first time that AQP4 deficiency alleviates experimental colitis in mice. Our study helps to understand the pathogenesis of inflammatory bowel diseases, and blocking AQP4 may represent a novel therapeutic approach for ulcerative colitis.—Wang, L., Tang, H., Wang, C., Hu, Y., Wang, S., Shen, L. Aquaporin 4 deficiency alleviates experimental colitis in mice. FASEB J. 33, 8935–8944 (2019). http://www.fasebj.org

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Section: Discussionsupporting

confidence: 55%

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confidence: 99%

Aquaporin 4 deficiency alleviates experimental colitis in mice

et al. 2019

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“…AQP1or Aquaporin‐1 is a protein channel that regulates osmotic gradient across cell membranes and promotes fluid transport . Aquaporins are implicated in immune cell migration and inflammatory events . Overexpression of AQP1 is associated with instability of pathogen‐containing vacuoles upon bacterial invasion .…”

Section: Discussionmentioning

confidence: 99%

“…52 Aquaporins are implicated in immune cell migration and inflammatory events. 53 Overexpression of AQP1 is associated with instability of pathogen-containing vacuoles upon bacterial invasion. 54 RA synovial cells show increased expression of AQP1.…”

Section: Rel Gene Is a Proto-oncogene Associated With B-cell T-cell mentioning

confidence: 99%

Biological links in periodontitis and rheumatoid arthritis: Discovery via text‐mining PubMed abstracts

Acharya

Liu

et al. 2018

J of Periodontal Research

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Background and Objective Primary research concerning molecular pathways that link rheumatoid arthritis with periodontitis is limited. Biomedical literature data mining can offer insights into putative linkage mechanisms toward hypothesis development, based on information discovery. The aim of this study was to explore potential Periodontitis‐Rheumatoid Arthritis biological links by analysing “overlapping” genes reported in biomedical abstracts. Material and Methods PubMed abstracts for terms: (a) “Periodontitis” or “Periodontal Diseases” (PD), (b) “Rheumatoid arthritis” (RA), and (c) their combination with “AND” (RA+PD), were each text‐mined to extract genes using “Human Genome Nomenclature Committee” (HGNC) symbols. A gene‐set common to RA and PD abstracts was determined (RA∩PD). Gene ontology (GO) profiles of RA∩PD and RA+PD were compared using “GoProfiler.” Minimum order protein‐protein interaction (PPI) and gene‐miRNA networks of “differential genes” between RA∩PD and RA+PD were constructed with “networkAnalyst.” Results Among 1676 genes documented in RA (10 5241 abstracts), and 893 genes in PD (80 982 abstracts), 535 genes were common (RA∩PD), from which 35 genes were also documented in RA+PD (415 abstracts). 41 GO‐terms significantly different between RA∩PD and RA+PD GO profiles represented 38 biological processes including; nitric oxide metabolism, immunoglobulin production, hormonal regulation, catabolic process down‐regulation, and leukocyte proliferation. The 500 differential genes’ PPI and gene‐miRNA networks showed REL, TRAF2, AQP1 genes, and miRNAs 335‐5p, 17‐5p, 93‐5p with genes HMOX1 and SP1 as hub nodes. Conclusions Text‐mining biomedical abstracts revealed potentially shared but un‐investigated links between PD and RA, meriting further research.

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“…Furthermore, their functions are of paramount importance in epithelial and endothelial cells, where their roles are clearly involved in fluid balance [68]. Besides their well-known peculiarities, it has been hypothesized that AQPs may be involved actively in cell migration, metabolism, and signal transduction [69]. AQP2, AQP5, AQP8, and AQP9 were usually found in endometrial samples [42,70].…”

Section: Aquaporins (Aqps) and Endometriosismentioning

confidence: 99%

Ion Channels in The Pathogenesis of Endometriosis: A Cutting-Edge Point of View

Riemma

Laganà

Schiattarella

et al. 2020

IJMS

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Background: Ion channels play a crucial role in many physiological processes. Several subtypes are expressed in the endometrium. Endometriosis is strictly correlated to estrogens and it is evident that expression and functionality of different ion channels are estrogen-dependent, fluctuating between the menstrual phases. However, their relationship with endometriosis is still unclear. Objective: To summarize the available literature data about the role of ion channels in the etiopathogenesis of endometriosis. Methods: A search on PubMed and Medline databases was performed from inception to November 2019. Results: Cystic fibrosis transmembrane conductance regulator (CFTR), transient receptor potentials (TRPs), aquaporins (AQPs), and chloride channel (ClC)-3 expression and activity were analyzed. CFTR expression changed during the menstrual phases and was enhanced in endometriosis samples; its overexpression promoted endometrial cell proliferation, migration, and invasion throughout nuclear factor kappa-light-chain-enhancer of activated B cells-urokinase plasminogen activator receptor (NFκB-uPAR) signaling pathway. No connection between TRPs and the pathogenesis of endometriosis was found. AQP5 activity was estrogen-increased and, through phosphatidylinositol-3-kinase and protein kinase B (PI3K/AKT), helped in vivo implantation of ectopic endometrium. In vitro, AQP9 participated in extracellular signal-regulated kinases/p38 mitogen-activated protein kinase (ERK/p38 MAPK) pathway and helped migration and invasion stimulating matrix metalloproteinase (MMP)2 and MMP9. ClC-3 was also overexpressed in ectopic endometrium and upregulated MMP9. Conclusion: Available evidence suggests a pivotal role of CFTR, AQPs, and ClC-3 in endometriosis etiopathogenesis. However, data obtained are not sufficient to establish a direct role of ion channels in the etiology of the disease. Further studies are needed to clarify this relationship.

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New Perspectives on the Potential Role of Aquaporins (AQPs) in the Physiology of Inflammation

Cited by 127 publications

References 115 publications

Aquaporin 4 deficiency alleviates experimental colitis in mice

Aquaporin 4 deficiency alleviates experimental colitis in mice

Biological links in periodontitis and rheumatoid arthritis: Discovery via text‐mining PubMed abstracts

Ion Channels in The Pathogenesis of Endometriosis: A Cutting-Edge Point of View

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