Abstract-According to the needs of the times, there is an urgent need for college students to carry out innovative education. Therefore, it is necessary to carry out the training mode of innovative and entrepreneurship talents based on three creative education. First of all, according to the training goal of "three innovation education", the author systematically decomposes and implements the knowledge structure, skill system and accomplishment requirements of talent training, and constructs a three training mode for college students to adapt to the characteristics of local colleges and universities. Secondly, the "three creative education" should be effectively incorporated into the teaching plan and credit system of professional education and cultural quality education, and a multi-level and threedimensional three creative education curriculum system should be established. Third, improve the rules and regulations, security system and incentive mechanism, and build a three platform for education and practice. Through the system of teaching theory and practice integration, effective combination of internal and external practice platform, innovation and entrepreneurship education to carry out the whole program, three-dimensional, systematic, personalized, cultivating high-quality innovative active spirit of innovation and strong independent entrepreneurship entrepreneurial talent.