New Progress in Medical Research of Bio-Humic Acid

Abstract

Humic acids are biological macromolecules. It has been 500 years since “WU-JIN-SAN” (i.e. humic acid) reported in Compendium of Materia Medica. In recent 30 years tens of medical companies and institutions have done regular clinical trials, toxicological and harmacological research on bio-humic acids. Besides, German, Polish, Swiss, Finland et al. have also done similar research, with the similar efficacy of Chinese herbal medicine like “Streagthening Vital Qi's Capacity to Resist Pathogens”, “Readjusting Yin and Yang”, “remedy defects and rectify errors” which build a scientific fundament for medical application of bio-humic acid. Although bio-humic acids was relatively weak in pharmacological studies, it was still traceable. As a drug, how to make a prescription in the pharmacopoeia? This is the key issues which affect the progress in humic medical research. The author consider: First, the use of low-carbon biodegradation reduces the complexity of bio-humic acid molecules,then acoording to the active component by bio-humic acid, Pharmacological-pharmacodynamic, and determining the scope of medical applications could gradually overcome the bottleneck of medical research in bio-humic acid, accelerat the progress of medical research of bio-humic acid.

Radioprotective Properties of Sodium Humate in Radiation-Induced Mutagenesis in Cultured Lymphocytes of Thyroid Cancer Patients

“…Repopulation as a reaction of organisms to irradiation exposure was studied in detail in many model systems, including its stimulation by antimutagens [19][20][21]. Well-known adaptogenic properties of humates suppose their impact also on other processes of post-radiation recovery [1][2][3][4]. The view on mechanisms of radioprotective action of sodium humate in the culture of human lymphocytes is supported by the results of our previous studies done in plant test-system.…”

“…Currently, the scientific literature presents numerous data on biological activity of humic substances. Their preparations are being used both in medicine and agriculture [1][2][3][4]. Humic substances are a complex of natural polymer compounds, products of humification, which are present in the soil, peat, brown coal, sapropel, etc.…”

“…The main component of the humic substances is humic acid, which physiologically active form is salts (humates). The feature of humic substances is the saturation of their molecules by most diverse functional groups, namely carboxyl, phenolic and alcoholic hydroxyls, quinoid groups, methoxy, amino and amido groups [1] that ultimately provides the widest range of their biological activity [2][3][4]. Particular attention is drawn to antitumor properties of humic substances.…”

“…In the last decade intense studies of humic substances have shown the potential of a significant extending of their pharmacological application. The scientific literature describes their antioxidant, immunostimulatory, anti-inflammatory and antiviral effects [1][2][3][4][10][11][12]. It was shown that humic substances may change the expression profile of more than 30 genes, and affect DNA methylation [13,14].…”

“…It was shown that humic substances may change the expression profile of more than 30 genes, and affect DNA methylation [13,14]. Considering adaptogenic and immune-stimulating properties of humic substances, their ability to increase non-specific resistance of a human body could be assumed [1][2][3][4][10][11][12]. There is an increasing interest in the study of their use in cancer radiotherapy to protect normal tissues, to improve the tolerability of the treatment, and to reduce the risk of early and late side effects.…”