“… 52 , 53 The signal-to-background ratio can also be improved by modulation of the dark and light state populations of a fluorophore using a modulated secondary laser to resolve signal from the autofluorescent background. 54 − 56 Finally, synthetic development of new fluorophores, both organic 57 − 59 and biological, 60 offers improved lifetimes as another route toward better fluorophores.…”
Section: Principles Of Single Molecule
Spectroscopy and Instrumental
mentioning
confidence: 99%
“…Therefore, excitation power should be selected to balance between reducing photophysical effects and obtaining adequate signal-to-noise ratio. Other hardware-based approaches that prevent unnecessary excitation of single moleucle fluorophores have been presented through modulating the excitation in sync with the time-gated data acquisition and inherent data conversion time of the detector. , The signal-to-background ratio can also be improved by modulation of the dark and light state populations of a fluorophore using a modulated secondary laser to resolve signal from the autofluorescent background. − Finally, synthetic development of new fluorophores, both organic − and biological, offers improved lifetimes as another route toward better fluorophores.…”
Section: Principles Of Single Molecule
Spectroscopy and Instrumental
...mentioning
“… 52 , 53 The signal-to-background ratio can also be improved by modulation of the dark and light state populations of a fluorophore using a modulated secondary laser to resolve signal from the autofluorescent background. 54 − 56 Finally, synthetic development of new fluorophores, both organic 57 − 59 and biological, 60 offers improved lifetimes as another route toward better fluorophores.…”
Section: Principles Of Single Molecule
Spectroscopy and Instrumental
mentioning
confidence: 99%
“…Therefore, excitation power should be selected to balance between reducing photophysical effects and obtaining adequate signal-to-noise ratio. Other hardware-based approaches that prevent unnecessary excitation of single moleucle fluorophores have been presented through modulating the excitation in sync with the time-gated data acquisition and inherent data conversion time of the detector. , The signal-to-background ratio can also be improved by modulation of the dark and light state populations of a fluorophore using a modulated secondary laser to resolve signal from the autofluorescent background. − Finally, synthetic development of new fluorophores, both organic − and biological, offers improved lifetimes as another route toward better fluorophores.…”
Section: Principles Of Single Molecule
Spectroscopy and Instrumental
...mentioning
“…1,2,3‐triazine and their derivatives are the new members of the class of heterocyclic compounds. This isomer was least studied because it is the least stable as compared to 1,2,4‐ and 1,3,5‐isomers and its synthetic routes are also limited in literature [128] . 1,2,4‐triazine and its derivatives with other heterocyclic compounds showed various utilities in the fields of pesticides, herbicides, dyes, and pharmaceuticals.…”
Section: Six Membered Heterocycles Having Three Nitrogen Atoms (Triaz...mentioning
Heterocyclic compounds play a tremendous role in the field of medicinal chemistry due to their association with diverse pharmacological properties. Most of the pharmaceutical drugs used in medicines possess a wide range of heterocyclic nucleus. It was decided basis on literature studies that various synthetic protocols like microwave‐assisted, nanocatalysed, green synthesis, click reaction, and multicomponent routes could be used for the betterment of the purity of products, selectivity, and better yields of the products. We have focused attention on the development of synthetic strategies of the above‐mentioned moieties because N‐, O‐ and S‐ containing heterocyclic compounds have seemed owing to a wide diversity of their biological activities viz. antioxidant, anticancer, anticonvulsant, anti‐inflammatory, neuroprotective, antiproliferative, anti‐obesity, antihyperglycemic, antihypercholesteroler, antiulcer, antidiabetic, antileishmanial, antitrypanosomal, antibiotic, etc. In this review article, an overview of the applications of synthetic protocols for the preparation of five‐membered and six‐membered heterocyclic compounds containing two or more heteroatoms (O, N, S) at different‐different positions along with their different potent and competent candidates against various diseases is presented in last 10–15 years.
“…Prolonged heating causes cleavage of the C–N bond (between C–3a and N-4) in 168 and rearrangement of the obtained betaines 169 to more stable 2,5-dihydro-1,2,3-triazines 170 . This relatively complex process produces triazines 170 in moderate yields (35–52%) 2006TL1721 , 2006JOC5679 . Scheme 18 …”
Section: Reactivity Of Fully Conjugated Ringsmentioning
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