New redox titrants in non-aqueous or partially aqueous media—VI11Part V: Talanta, 1975, 22, 57.

Nair, C.G.R.; Indrasenan, P.

doi:10.1016/0039-9140(76)80178-6

Cited by 53 publications

(21 citation statements)

References 4 publications

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“…The brominating agent TsNBr 2 employed for this purpose was prepared from chloramine-T, following a literature procedure. 17 Firstly, 1-phenylethanol was used as a model substrate. The reaction was carried out by adding TsNBr 2 (1.0 mmol) to a solution of the alcohol (1 mmol) in acetonitrile (2 ml) at room temperature.…”

Section: Resultsmentioning

confidence: 99%

A new metal-free protocol for oxidation of alcohols using TsNBr2 without catalyst

Phukan¹,

Chakraborty²,

Saikia³

2010

Arkivoc

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Section: Resultsmentioning

confidence: 99%

A new metal-free protocol for oxidation of alcohols using TsNBr2 without catalyst

Phukan¹,

Chakraborty²,

Saikia³

2010

Arkivoc

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“…The oxidant BAT was prepared and purified using the method of Nair and Indrasenan [16]. Its purity was checked by iodometric and spectroscopic data [16,17].…”

Section: Methodsmentioning

confidence: 99%

“…Its purity was checked by iodometric and spectroscopic data [16,17]. Aqueous solutions of BAT were prepared, standardized by the iodometric method, and preserved in amber-colored bottles until use, to prevent its photochemical deterioration.…”

Section: Methodsmentioning

confidence: 99%

Kinetic and Mechanistic Study of Oxidation of Piperazines by Bromamine-T in Acidic Medium

-¹,

Venkatesha²,

Ananda³

et al. 2013

MRC

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Oxidations of piperazine, 1-methylpiperazine and 1-ethylpiperazine by bromamine-T (BAT) in buffered acidic medium have been kinetically studied at 303 K. The reaction shows a first-order dependence of the rate each on [BAT] 0 and [piperazine] 0 , and an inverse fractional-order dependence on [H + ]. The additions of halide ions and the reduction product of BAT, p-toluenesulfonamide, have no effect on the reaction rate. The variation of ionic strength of the solvent medium has no influence on the rate. Activation parameters have been evaluated from the Arrhenius and Eyring plots. A common mechanism consistent with the kinetic data has been proposed for all piperazines. The protonation constants of substrates have been evaluated. The Hammett linear free-energy relationship has been observed for the reaction with ρ = −0.5 indicating that the electron-donating groups enhance the reaction rate by stabilizing the transition state. An isokinetic relationship observed shows β = 368 K indicating the dominance of enthalpy factors on the reaction rate.

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“…The substrate cetrizine dihydrochloride is of analytical grade of purity, was provided from University of Mysore, Mysore, India, It was used as received and an aqueous solution of the desired strength of the substrate was prepared freshly each time whenever required. The oxidant, BAT, was prepared by standard procedure 16,17 and the authenticity of the product was confirmed by checking the halogen content iodometrically. An aqueous solution of BAT was prepared afresh whenever required, standardized by iodometric method and preserved in amber-coloured bottles to prevent any of its photochemical deterioration.…”

Section: Methodsmentioning

confidence: 99%

Kinetic and Mechanistic Studies of Oxidation of an Antiallergic Drug with Bromamine-T in Acid and Alkaline Media

Puttaswamy¹,

Sukhdev²

2012

Bulletin of the Korean Chemical Society

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Cetrizine dihydrochloride (CTZH) is widely used as an anti-allergic drug. Sodium N-bromo-p-toluenesulfonamide or bromamine-T (BAT) is the bromine analogue of chloramine-T (CAT) and is found to be a better oxidizing agent than CAT. In the present research, the kinetics of oxidation of CTZH with BAT in acid and alkaline media was studied at 313 K. The experimental rate laws obtained are:−0.48 in acid medium and[PTS] −0.40 in alkaline medium where PTS is p-toluenesulfonamide. Activation parameters and reaction constants were evaluated. The solvent isotope effect was studied using D 2 O. The dielectric effect is positive. The stoichiometry of the reaction was found to be 1:1 and the oxidation products were identified as 4-chlorobenzophenone and (2-piperazin-1-yl-ethoxy)-acetic acid in both media. The rate of oxidation of CTZH is faster in acid medium. Suitable mechanisms and related rate laws have been worked out.

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New redox titrants in non-aqueous or partially aqueous media—VI11Part V: Talanta, 1975, 22, 57.

Cited by 53 publications

References 4 publications

A new metal-free protocol for oxidation of alcohols using TsNBr2 without catalyst

A new metal-free protocol for oxidation of alcohols using TsNBr2 without catalyst

Kinetic and Mechanistic Study of Oxidation of Piperazines by Bromamine-T in Acidic Medium

Kinetic and Mechanistic Studies of Oxidation of an Antiallergic Drug with Bromamine-T in Acid and Alkaline Media

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