New spermidine alkaloids from Capparis spinosa roots

Fu, Xiao; Wu, Tao; Abdurahim, M.; Su, Zhe; Hou, Xue; Aisa, Haji Akber; Wu, Hongyi

doi:10.1016/j.phytol.2008.01.001

Cited by 44 publications

(34 citation statements)

References 4 publications

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“…C. spinosa is used in phytomedicine around the world as an antihyperglycemic (Eddouks et al, 2004), antihepatotoxic (Eddouks et al, 2005;Gadgoli & Mishra, 1999), antioxidant (Germano et al, 2002;Steenkamp et al, 2004), antifungal (Ali-Shtayeh & Abu Ghdeib, 1999), anti-inflammatory (Al-Said et al, 1988) and antidiabetic (Eddouks et al, 2004;Yaniv et al, 1987). In China, C. spinosa has been used since ancient times in traditional medicine especially for the treatment of rheumatism and gout (Fu et al, 2008). With regard to the constituents of the C. spinosa, a number of flavonoids, alkaloids, terpenoids, volatile oils and fatty acids have been reported (Matthäus & Ozcan, 2002;Sharaf et al, 1997;Khanfar et al, 2003;Yang et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

A new antioxidant compound fromCapparis spinosa

Yang¹,

Wang

Liu

et al. 2010

Pharmaceutical Biology

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Section: Introductionmentioning

confidence: 99%

A new antioxidant compound fromCapparis spinosa

Yang¹,

Wang

Liu

et al. 2010

Pharmaceutical Biology

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“…Alkaloids like capparisine, cadabicine in free and glycosylate forms are known as main components of C. spinosa root (Fu et al, 2008) together with a more polar alkaloid, stachydrine (Khatib et al, 2016). These alkaloids are differently distributed in the four samples.…”

Section: Discussionmentioning

confidence: 99%

“…S1. The corresponding mass spectra with the accurate mass values confirm not only the presence of the alkaloids previously isolated from this root (Fu et al, 2008) but also of several analogous.…”

Section: Composition Of the Dried Extracts (De)mentioning

confidence: 99%

“…In Jordanian traditional medicine, root bark are macerated and placed between gauze on aching area for 15-25 min in order to relieve inflammation and muscle pain (Hudaib et al, 2008). Regarding the root composition it has been reported the presence of alkaloids belonging to the spermidine group (Fu et al, 2008) together with the presence of stachydrine, a more polar alkaloid typical of the caper leaves too (Batanouny and Drissamnauer, 2005;Buckingham, 1994). Interestingly, the use of polyamine alkaloids, as those of the spermidine group, has been suggested as efficacious in arthritis disease (Iezaki et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Acute effect of Capparis spinosa root extracts on rat articular pain

Maresca

Micheli

Mannelli

et al. 2016

Journal of Ethnopharmacology

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a b s t r a c tEthnopharmacological relevance: Capparis spinosa L. originates from dry regions of Asia and Mediterranean basin. In traditional medicine of these areas, infusions from caper root are considered to be beneficial for the treatment of rheumatism, gout and against abdominal pains. Aim of the study: To evaluate the pain relieving properties of a Syrian cultivar of Capparis spinosa roots in rat models of osteoarthritis and rheumatoid arthritis. Materials and methods: Decoction (DEC) and hydroalcoholic extract (EtH 2 O) were obtained from powdered roots; the latter was further separated in CH 2 Cl 2 and aqueous (H 2 O-Res) fractions. The extracts were characterized in terms of spermidine alkaloids by HPLC/DAD/MS and stachydrine by NMR. Different amount of free and glycosilated forms of capparispine and analogues (from 0.5% w/w for DEC up to 7.6% w/w for CH 2 Cl 2 fraction) were detected. Rat models of rheumatoid arthritis and osteoarthritis were induced by the intra-articular administration of Complete Freund's Adjuvant (CFA) or monosodium iodoacetate (MIA), respectively. Results: Fourteenth days after CFA or MIA injection, the different preparations of Capparis spinosa (3, 30, 100 and 300 mg kg À 1 ) were acutely administered p.o.. Powdered roots (300 mg kg ) significantly reduced hypersensitivity to mechanical noxious stimuli as well as spontaneous pain evaluated as hind limb bearing alterations in both models. The CH 2 Cl 2 and the H 2 O-Res (30 mg kg À 1 ) were the most potent in reverting pain threshold alterations despite the different content of free alkaloids. Conclusions: Capparis spinosa extracts relieved pain related to rheumatoid arthritis and osteoarthritis after single administration. A synergistic effect due to a specific "phytochemical mixture" is suggested.

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“…Furthermore, chemical and biological studies reported the presence of many beneficial compounds , Tesoriere et al 2007) and revealed significant antidiabetic, antisclerosis, antimicrobial, antioxidative, antiinflammatory, immunomodulatory and antiviral activities , Fu et al, 2008.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of antioxidant properties and assessment of genetic diversity of Capparis spinosa cultivated in Pantelleria Island.

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New spermidine alkaloids from Capparis spinosa roots

Cited by 44 publications

References 4 publications

A new antioxidant compound fromCapparis spinosa

A new antioxidant compound fromCapparis spinosa

Acute effect of Capparis spinosa root extracts on rat articular pain

Evaluation of antioxidant properties and assessment of genetic diversity of Capparis spinosa cultivated in Pantelleria Island.

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