New Strategies for Fluorescent Probe Design in Medical Diagnostic Imaging

Kobayashi, Hisataka; Ogawa, Mikako; Alford, Raphael; Choyke, Peter L.; Urano, Yasuteru

doi:10.1021/cr900263j

Cited by 2,040 publications

(1,399 citation statements)

References 162 publications

Supporting

Mentioning

1,381

Contrasting

Unclassified

Order By: Relevance

“…[748] This technique is based on the detection of light, absorbed and emitted by fluorochrome concentrations as a source of contrast. [749] Specifically, fluorescent molecules emit photons with longer wavelengths than that of formerly adsorbed. [750] Generally, fluorescent agents that emit photons with wavelengths NIR range (650-900 nm) correspond to optical imaging due to their capability of passing through biological tissues allowing for a whole body tomography in rodents.…”

Section: Optical Imagingmentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

203

171

View full text Add to dashboard Cite

In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

show abstract

Section: Optical Imagingmentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

203

171

View full text Add to dashboard Cite

show abstract

“…Among all sensing technologies, photon‐signal‐based biosensors such as organic dyes,1, 2, 3, 4 metal complexes,5, 6, 7, 8, 9, 10 and semiconductor nanocrystals11 are the most commonly used ones. However, these probes have several limitations in detection or sensing.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances on Functionalized Upconversion Nanoparticles for Detection of Small Molecules and Ions in Biosystems

2018

View full text Add to dashboard Cite

Significant progress on upconversion‐nanoparticle (UCNP)‐based probes is witnessed in recent years. Compared with traditional fluorescent probes (e.g., organic dyes, metal complexes, or inorganic quantum dots), UCNPs have many advantages such as non‐autofluorescence, high chemical stability, large light‐penetration depth, long lifetime, and less damage to samples. This article focuses on recent achievements in the usage of lanthanide‐doped UCNPs as efficient probes for biodetection since 2014. The mechanisms of upconversion as well as the luminescence resonance energy transfer process is introduced first, followed by a detailed summary on the recent researches of UCNP‐based biodetections including the detection of inorganic ions, gas molecules, reactive oxygen species, and thiols and hydrogen sulfide.

show abstract

“…The efficiency of the FRET process depends on the distance between the donor and acceptor units, on their alignment, on the spectral overlap between the donor emission and the acceptor absorbance and on the fluorescence quantum yield of the donor, thereby providing versatile ways of FRET modulation [3]. FRET is widely used in fluorescence sensing and imaging, utilizing the inherent advantage of ratiometric measurements [4][5][6]. FRET-related techniques are particularly important in biomedical research, exploiting that FRET is sensitive in the 1-10 nm distance range that matches the dimensions of proteins, polynucleotides, or the thickness of cell membranes [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Supramolecular FRET modulation by pseudorotaxane formation of a ditopic stilbazolium dye and carboxylato-pillar[5]arene

et al. 2016

View full text Add to dashboard Cite

show abstract

New Strategies for Fluorescent Probe Design in Medical Diagnostic Imaging

Cited by 2,040 publications

References 162 publications

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Recent Advances on Functionalized Upconversion Nanoparticles for Detection of Small Molecules and Ions in Biosystems

Supramolecular FRET modulation by pseudorotaxane formation of a ditopic stilbazolium dye and carboxylato-pillar[5]arene

Contact Info

Product

Resources

About