New techniques of analyzing the healing process of artificial vascular grafts, transmural vascularization, and endothelialization

Kogel, H.; Amselgruber, Werner; Frösch, D.; Mohr, W.; Cyba-Altunbay, S

doi:10.1007/bf01856031

Cited by 18 publications

(1 citation statement)

References 4 publications

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“…4,5 Moreover, the solid wall is not beneficial for the internal and external mass exchange of vascular graft walls. 6 Therefore, porous prostheses, such as textile vascular grafts, were then considered favorable to form a new endothelium, to facilitate an appropriate vascularization [7][8][9] and a long-term patency. 10 In particular, a complete regenerated endothelium has been widely seen as an ideal strategy to guarantee a long-term patency of a vascular graft.…”

Section: Introductionmentioning

confidence: 99%

Exploration into practical significance of integral water permeability of textile vascular grafts

Guan

Fang

et al. 2021

Journal of Applied Biomaterials & Functional Materials

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Water permeability of textile vascular grafts has been considered as a key indicator for predicting blood permeability after implantation. However, a correlation between water and blood permeability has not been established yet. Therefore, even though the water permeability of a vascular graft can be tested according to the standard ISO 7198, the results fail to guide a manufacturer or a surgeon to judge whether this vascular graft needs pre-clotting or not prior to implantation. As a result, all commercial graft products show almost zero water permeability, which leads to the loss of advantages that textile vascular grafts have the pore size-controlled porous wall. To solve this problem, four types of woven vascular grafts were designed and manufactured in the present work. Then their permeability to water, simulated plasma, and anticoagulated whole blood were measured at graded pressures from 8 to 16 kPa. Moreover, the correlations among the water permeability, the simulated plasma permeability, and the anticoagulated whole blood permeability were established. The results suggest that relatively steady correlations exist between the water permeability and the anticoagulated whole blood permeability, and that the evaluation of the blood permeability using the water permeability is feasible and objective. The present work provides a quantitative method for evaluating the blood permeability using the water permeability, and the latter is thus endowed with practical significance for guiding designs and clinical pre-clotting operations of textiles vascular grafts.

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