New Terpenes from the Egyptian Soft Coral  Sarcophyton ehrenbergi

Elkhateeb, Ahmed; El‐Beih, Ahmed A.; Gamal‐Eldeen, Amira M.; Atia, Mohamed A. M.; Ohta, Shigeru; Paré, Paul W.; Hegazy, Mohamed‐Elamir F.

doi:10.3390/md12041977

Cited by 33 publications

(47 citation statements)

References 14 publications

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“…1,2 These cembrane diterpenoids exhibit a wide range of structural diversity and biological activity. [3][4][5][6][7][8][9][10] Cembranoids, the main metabolites identied in the genus Sarcophyton have been shown to serve as an effective chemical defense against natural predators of coral. 11 The leather coral Sarcophyton ehrenbergi (von Marenzeller, 1886) produces diverse metabolites with distinct chemical structures as well as promising biological activities.…”

Section: Introductionmentioning

confidence: 99%

Sarcoehrenbergilides D–F: cytotoxic cembrene diterpenoids from the soft coral Sarcophyton ehrenbergi

et al. 2019

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Section: Introductionmentioning

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Sarcoehrenbergilides D–F: cytotoxic cembrene diterpenoids from the soft coral Sarcophyton ehrenbergi

et al. 2019

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“…7β-chloro-8α-hydroxy-12acetoxy-deepoxysarcophine 217 was close to 7-keto-8α-hydroxy-deepoxysarcophine 216 except for the disappearance of ketone signal at C-7 which co-exists with the presence of an up fielded signal at δ62.9 (C-7), a downfield of C-20 and the presence of carbonyl and methyl group at 170 and 22.2, respectively, were isolated from S. ehrenbergi. [79].…”

Section: Introductionmentioning

confidence: 99%

Chemical Diversity in Species Belonging to Soft Coral Genus Sacrophyton and Its Impact on Biological Activity: A Review

et al. 2020

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One of the most widely distributed soft coral species, found especially in shallow waters of the Indo-Pacific region, Red Sea, Mediterranean Sea, and also the Arctic, is genus Sacrophyton. The total number of species belonging to it was estimated to be 40. Sarcophyton species are considered to be a reservoir of bioactive natural metabolites. Secondary metabolites isolated from members belonging to this genus show great chemical diversity. They are rich in terpenoids, in particular, cembranoids diterpenes, tetratepenoids, triterpenoids, and ceramide, in addition to steroids, sesquiterpenes, and fatty acids. They showed a broad range of potent biological activities, such as antitumor, neuroprotective, antimicrobial, antiviral, antidiabetic, antifouling, and anti-inflammatory activity. This review presents all isolated secondary metabolites from species of genera Sacrophyton, as well as their reported biological activities covering a period of about two decades (1998–2019). It deals with 481 metabolites, including 323 diterpenes, 39 biscembranoids, 11 sesquiterpenes, 53 polyoxygenated sterols, and 55 miscellaneous and their pharmacological activities.

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“…The terpenoids function as the main chemical defense mechanism against natural predators. Soft corals have been the subject of bioactivity studies since the 19th century (Elkhateeb et al, 2014). Soft corals of the genus Sinularia and Sarcophyton have known as sources of terpenoids and steroids (Wang, Hsieh, & Duh, 2012;Tseng, Wang, & Duh, 2012).…”

Section: Introductionmentioning

confidence: 99%

Screening of Antibacterial and Antioxidant Activity from the Soft Corals Sinularia sp. and Sarcophyton sp. Origin Palu Bay, Central Sulawesi, Indonesia

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et al. 2019

Squalen Bull. Marine Fisheries Postharvest Biotech.

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This study aimed to evaluate the potential antibacterial and antioxidant activities of Sinulariasp. and Sarcophyton sp. from the Palu Bay, Central Sulawesi, Indonesia. Soft corals were identified as Sinulariasp. (SC1), Sinularia sp. (SC2), andSarcophytonsp. (SC3). Antibacterial activity was examined using agar diffusion well method. Antioxidant activity was measured by the DPPH radical scavenging method. The samples were macerated in MeOH: DCM. The crude extracts were partitioned with DCM, EtOAc, and BuOH. The crude extract of Sinulariasp. (SC2) showed a very strong antibacterial activity as it was able to inhibit the growth of Staphylococcus aureusand Escherichia coliup to 10 mg/mL. Sinularia sp. (SC1) crude extract showed strong activity againstS. aureus, whereas it showed moderate against E. coli.Sarcophyton sp. (SC3) crude extract showed moderate activity against S. aureus, whereas it showed weak against E. coli. The partition fractions of the three soft coral extracts had the potential to be a potent antioxidant agent.

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New Terpenes from the Egyptian Soft Coral Sarcophyton ehrenbergi

Cited by 33 publications

References 14 publications

Sarcoehrenbergilides D–F: cytotoxic cembrene diterpenoids from the soft coral Sarcophyton ehrenbergi

Sarcoehrenbergilides D–F: cytotoxic cembrene diterpenoids from the soft coral Sarcophyton ehrenbergi

Chemical Diversity in Species Belonging to Soft Coral Genus Sacrophyton and Its Impact on Biological Activity: A Review

Screening of Antibacterial and Antioxidant Activity from the Soft Corals Sinularia sp. and Sarcophyton sp. Origin Palu Bay, Central Sulawesi, Indonesia

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