New Ti–Mo–Si materials for bone prosthesis applications

Vereştiuc, Liliana; Spataru, Mihaela Claudia; Bălțatu, Mădălina Simona; Butnaru, Maria; Solcan, Carmen; Sandu, Andrei Victor; Voiculescu, Ionelia; Geantă, Victor; Vizureanu, Petrică

doi:10.1016/j.jmbbm.2020.104198

Cited by 36 publications

(36 citation statements)

References 27 publications

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“…An effective sealing strongly curtails the risk of periodontal pocket formation, which is the cause of epithelial downgrowth and bacterial infection. Moreover, fibroblasts are known to be the first promoters of the inflammatory cascade through the secretion of chemokines IL6, IL8 and monocyte chemoattractant protein 1 (MCP1) [34]. Contact guidance represents a suitable tool to ease implant colonization, thus preventing a pro-inflammatory signaling cascade as it occurs in case of fibroblasts' poor surface adaptability.…”

Section: Discussionmentioning

confidence: 99%

“…The mechanism of anti-fouling of bacteria due to surface nano-structuring is investigated much more in detail. Ti-Mo alloys were selected as beta alloys, because even if they are still less studied than Ti-cp and Ti6Al4V, they are promising as possible bone implants [34,35] and specific surface modifications are needed to improve their surface properties [36]. On the other hand, almost no specific research is reported in the literature for increasing the soft tissue adhesion of these alloys, to the best of the authors' knowledge.…”

Section: Introductionmentioning

confidence: 99%

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Contact Guidance Effect and Prevention of Microfouling on a Beta Titanium Alloy Surface Structured by Electron-Beam Technology

et al. 2021

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Nano- and micro-structuring of implantable materials constitute a promising approach to introduce mechanical contact guidance effect, drive cells colonization, as well as to prevent bacteria adhesion and biofilm aggregation, through antifouling topography. Accordingly, this paper aims to extend the application of e-beam surface texturing and nano-structuring to the beta titanium alloys, which are of great interest for biomedical implants because of the low Young modulus and the reduction of the stress shielding effect. The paper shows that surface texturing on the micro-scale (micro-grooves) is functional to a contact guidance effect on gingival fibroblasts. Moreover, nano-structuring, derived from the e-beam surface treatment, is effective to prevent microfouling. In fact, human fibroblasts were cultivated directly onto grooved specimens showing to sense the surface micro-structure thus spreading following the grooves’ orientation. Moreover, Staphylococcus aureus colonies adhesion was prevented by the nano-topographies in comparison to the mirror-polished control, thus demonstrating promising antifouling properties. Furthermore, the research goes into detail to understand the mechanism of microfouling prevention due to nano-topography and microstructure.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Contact Guidance Effect and Prevention of Microfouling on a Beta Titanium Alloy Surface Structured by Electron-Beam Technology

et al. 2021

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“…The first method is to indirectly affect the mechanical properties by chemical composition control. For example, L.Verestiuc et al [ 5 , 6 ] analyzed the effect of Si addition on Ti-15Mo alloy and confirmed significant changes of elastic modulus. Zirconium, as an alloying element for titanium, is highly safe for the human body, as it is a non-toxic element, having shown no mutagenic or carcinogenic effects.…”

Section: Introductionmentioning

confidence: 98%

Fabrication and Characterization of New Functional Graded Material Based on Ti, Ta, and Zr by Powder Metallurgy Method

et al. 2021

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In view of the aging population and various diseases worldwide, the demand for implants has been rapidly increasing. Despite the efforts of doctors, engineers, and medical companies, the fabrication of and procedures associated with implants have not yet been perfected. Therefore, a high percentage of premature implantations has been observed. The main problem with metal implants is the mechanical mismatch between human bone and the implant material. Zirconium/titanium-based materials with graded porosity and composition were prepared by powder metallurgy. The whole samples are comprised of three zones, with a radial gradient in the phase composition, microstructure, and pore structure. The samples were prepared by a three-step powder metallurgy method. The microstructure and properties were observed to change gradually with the distance from the center of the sample. The x-ray diffraction analysis and microstructure observation confirmed the formation of diffusive connections between the particular areas. Additionally, the mechanical properties of the obtained materials were checked, with respect to the distance from the center of the sample. An analysis of the corrosion properties of the obtained materials was also carried out.

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“…Globally, implantology aims to use materials with specific biological and biomechanical characteristics, as high as possible [1], and titanium alloys have advantages both in terms of reducing risks to patients during and after medical interventions, and in their efficacy and biocompatibility with human tissue [2].…”

Section: Introductionmentioning

confidence: 99%

New Titanium Alloys, Promising Materials for Medical Devices

et al. 2021

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Titanium alloys are used in medical devices due to their mechanical properties, but also for their corrosion resistance. The natural passivation of titanium-based biomaterials, on the surface of which a dense and coherent film of nanometric thickness is formed, composed mainly of TiO2, determines an apparent bioactivity of them. In this paper, the method of obtaining new Ti20MoxSi alloys (x = 0.0, 0.5, 0.75, and 1.0) is presented, their microstructure is analyzed, and their electrochemical responses in Ringer´s solution were systematically investigated by linear polarization, cyclic potential dynamic polarization, and electrochemical impedance spectroscopy (EIS). The alloys corrosion resistance is high, and no evidence of localized breakdown of the passive layer was observed. There is no regularity determined by the composition of the alloys, in terms of corrosion resistance, but it seems that the most resistant is Ti20Mo1.0Si.

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New Ti–Mo–Si materials for bone prosthesis applications

Cited by 36 publications

References 27 publications

Contact Guidance Effect and Prevention of Microfouling on a Beta Titanium Alloy Surface Structured by Electron-Beam Technology

Contact Guidance Effect and Prevention of Microfouling on a Beta Titanium Alloy Surface Structured by Electron-Beam Technology

Fabrication and Characterization of New Functional Graded Material Based on Ti, Ta, and Zr by Powder Metallurgy Method

New Titanium Alloys, Promising Materials for Medical Devices

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