New triterpene glycosides from Ziziphi Spinosae Semen

Wang, Yu; Ding, Bo; Luo, Dan; Chen, Liuyuan; Hou, Yunlong; Dai, Yi; Yao, Xin‐Sheng

doi:10.1016/j.fitote.2013.07.013

Cited by 25 publications

(16 citation statements)

References 13 publications

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“…[29] Similarly, C28 was identified as jujuboside I, which was previously separated from Ziziphi Spinosae Seme. [30] Although the compounds C29 and C31 also produced the same fragment ions with C27, C28, and C30, there were not corresponded saponins reported in the previous literature. For compound C22, its molecular ion at m/z 1077 exhibited losses of 132 u and 162 u, yielding to fragment ions at m/z 945 and 783 characteristic of a pentose and a hexose, respectively.…”

Section: Saponinsmentioning

confidence: 62%

Identification of bitter compounds from dried fruit of Ziziphus jujuba cv. Junzao

Ding

Zhang

et al. 2017

International Journal of Food Properties

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Bitterness in dried jujube fruit can adversely influence its palatability and consumer acceptability. In the present investigation, sensory-guided fractionation with techniques of liquid-liquid extraction, macroporous resin separation, and LC-MS/QTof was applied to identify the bitter compounds in dried jujube fruit (Z. jujuba cv. junzao). The results showed that bitter substances can be successfully extracted from dried jujube fruit using ethanol followed by n-butanol solution. The extract could then be further separated into five fractions by utilizing the macroporous resin separation technique. From this, three bitter fractions were obtained where 35 compounds, including 7 nitrogen compounds, 14 flavonoids, 12 saponins, and 2 fatty acid oxides，were tentatively identified. Based on the structures of these compounds, bitterness generation is likely to result from endogenous phytochemicals of jujube fruit and Maillard reactions during drying processing and also storage. ARTICLE HISTORY

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Section: Saponinsmentioning

confidence: 62%

Identification of bitter compounds from dried fruit of Ziziphus jujuba cv. Junzao

Ding

Zhang

et al. 2017

International Journal of Food Properties

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“…In addition, with the development of mass spectrometry, multiple constituents of the components of DFD have been analyzed and characterized in recent years [29][30][31][32][33][34]. Modern pharmacological studies have shown that the components of DFD have anti-inflammatory [35][36][37][38][39], antioxidative stress [40][41][42], and myocardial protection [42][43][44][45] effects. Inflammation and oxidative stress are closely related to arrhythmia [46][47][48].…”

Section: Discussionmentioning

confidence: 99%

Antiarrhythmic Mechanisms of Chinese Herbal Medicine Dingji Fumai Decoction

Liang

Zhou

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Background. Dingji Fumai decoction (DFD) is used to treat ventricular arrhythmia, and it has provided a very good curative effect. However, its cellular electrophysiological mechanism is unknown. Methods. Electrocardiogram was recorded, and oxidative stress response and ion-channel-related molecules were detected in rats with barium chloride- and aconitine-induced ventricular arrhythmia. Moreover, whole-cell patch-clamp assay was used to investigate the inhibitory effect of DFD on Nav1.5 in Chinese hamster ovary cells. Results. DFD prolonged the occurrence time and shortened the duration of ventricular arrhythmia, decreased the malondialdehyde and increased the superoxide dismutase, and alleviated the activation of Na+-K+-ATPase and connexin-43. DFD suppressed Nav1.5dose-dependently with an IC50 of 24.0 ± 2.4 mg/mL. Conclusions. The clinical antiarrhythmic mechanisms of DFD are based on its antioxidant potential, alleviation of Na+-K+-ATPase and connexin-43, and class I antiarrhythmic properties by suppressing Nav1.5dose-dependently with an IC50 of 24.0 ± 2.4 mg/mL.

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“…It was reported that ZSS contained a variety of complex chemical ingredients, such as flavonoids, saponins, alkaloids and three triterpenoids, etc [27][28][29][30][31]. Thus, the MS was operated under both positive and negative ion modes to screen all these relative compounds in ZSS as comprehensively as possible.…”

Section: Experimental Conditions Optimizationmentioning

confidence: 99%

Development of an analytical strategy to identify and classify the global chemical constituents of Ziziphi Spinosae Semen by using UHPLC with quadrupole time‐of‐flight mass spectrometry combined with multiple data‐processing approaches

Zhu

Xiao

Pei

et al. 2018

J of Separation Science

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According to traditional Chinese medical theory, Ziziphi Spinosae Semen needs to be stir-fried before clinical application for its sedative-hypnotic effect enhancement. A rapid and comprehensive analysis strategy of ultra high performance liquid chromatography with quadrupole time-of-flight mass spectrometry and multiple data analysis platforms was developed for the efficient and sensitive identification of components in crude and parched Ziziphi Spinosae Semen to explore the composition changes that happen during the stir-frying process. Both positive and negative ion modes were applied for mass spectrometry detection, and 40 components were identified from crude and parched Ziziphi Spinosae Semen, respectively. Principal component analysis and t-test were applied to find differences between crude and parched Ziziphi Spinosae Semen. As a result, Ziziphi Spinosae Semen samples could be clearly divided into two groups according to their processing methods, and 19 key markers that contributed to the classification significantly (P < 0.05) were found. This kind of change in contents of components might be responsible for the recommended clinical application of parched Ziziphi Spinosae Semen.

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New triterpene glycosides from Ziziphi Spinosae Semen

Cited by 25 publications

References 13 publications

Identification of bitter compounds from dried fruit of Ziziphus jujuba cv. Junzao

Identification of bitter compounds from dried fruit of Ziziphus jujuba cv. Junzao

Antiarrhythmic Mechanisms of Chinese Herbal Medicine Dingji Fumai Decoction

Development of an analytical strategy to identify and classify the global chemical constituents of Ziziphi Spinosae Semen by using UHPLC with quadrupole time‐of‐flight mass spectrometry combined with multiple data‐processing approaches

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