New way of application of the bromate–bromide mixture in kinetic analysis

López-Cueto, Guillermo; Ostra, Miren; Ubide, Carlos

doi:10.1016/s0003-2670(01)01250-8

Cited by 15 publications

(21 citation statements)

References 19 publications

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“…no reaction occurs between ASA and bromine, and bromine is consumed by the bromination of salicylic acid. Although this premise is essential for the proposals in this work, historically there has been some confusion [8,23,24,25]. To confirm this premise simulation of the whole process was tried and compared with experimental results.…”

Section: Resultsmentioning

confidence: 86%

“…The ASA-bromine system According to previous work [7] the reactions in the system ASA-bromine are those given by Eqs. (1) and (2), i.e.…”

Section: Resultsmentioning

confidence: 99%

“…Then SA becomes tribrominated in a rapid reaction, to give the product SA.3Br (from now on, P). Comparing the pseudo-first-order rate constants for the overall bromine consumption and for the hydrolysis of ASA it has been established that bromine reacts with the product SA, but not with ASA [7]. The mechanism below is followed:…”

Section: Guillermo López-cueto · Miren Ostra · Carlos Ubidementioning

confidence: 99%

“…Multivariate calibration methods, e.g. partial least-squares regression (PLS), have prevailed as the algorithms most used to treat experimental reaction kinetics data obtained at several wavelengths [5,6,7], although the possibility of implementing new and simple kinetic methods of determination, whenever the reaction kinetics allow, must be foreseen.…”

Section: Introductionmentioning

confidence: 99%

“…Bromine has also recently been used for multicomponent kinetic determinations after applying multivariate calibration techniques to kinetic spectrophotometric data. Mixtures of acetylsalicylic acid (ASA) and paracetamol (AAP) have been resolved by partial least-squares regression (PLS) applied to reaction profiles obtained, at several wavelengths, from the ASA-AAP-bromine system [7]. Some peculiar features of the reactions involved in the system ASA-bromine can, on the other hand, under some conditions, enable new and simpler approaches to the resolution of mixtures of ASA (as slow component) and a second, rapidly reacting, component (AAP or any other) by a kinetic method.…”

Section: Introductionmentioning

confidence: 99%

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The acetylsalicylic acid-bromine system for multicomponent kinetic determinations

López-Cueto

Ostra

Ubide

2002

Analytical and Bioanalytical Chemistry

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When acetylsalicylic acid (ASA) is added to a bromine solution, slow decay of the bromine concentration occurs. Hydrolysis of ASA yields salicylic acid (SA) slowly, and bromine reacts rapidly with SA but not with ASA. Simulated reaction profiles based on a two-step reaction scheme agree closely with the experimental profiles. This behaviour can be used to develop kinetic methods for resolution of mixtures of ASA and a second component that reacts rapidly with bromine. A remarkable practical feature of these methods is that the faster the reaction between bromine and the second component, the simpler and easier the analytical method. The reaction between hydroquinone (HQ) and bromine is rapid and a very simple analytical method is proposed. Mean validation errors of 2.8% for HQ and 7.2% for ASA have been found with concentration ratios [ASA]:[HQ] ranging between 0.32 and 19.4. The reaction between paracetamol (AAP) and bromine is not so fast and more complicated calibration methods are required. After use of a calibration plane mean validation errors of 2.7% for AAP and 8.1% for ASA have been found with concentration ratios ranging between 1.28 and 77.5. Similar kinetic approaches should be possible with many other mixtures of ASA and a second fast-reacting component, because bromine reacts with many inorganic and organic species by oxidation-reduction, substitution, and addition reactions.

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Section: Resultsmentioning

confidence: 86%

“…The ASA-bromine system According to previous work [7] the reactions in the system ASA-bromine are those given by Eqs. (1) and (2), i.e.…”

Section: Resultsmentioning

confidence: 99%

Section: Guillermo López-cueto · Miren Ostra · Carlos Ubidementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The acetylsalicylic acid-bromine system for multicomponent kinetic determinations

López-Cueto

Ostra

Ubide

2002

Analytical and Bioanalytical Chemistry

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A sensitive spectrophotometric method for the determination of propranolol HCl based on oxidation bromination reactions

El‐Didamony

2010

Drug Testing and Analysis

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Three new, simple, sensitive, rapid and economical spectrophotometric methods (A, B and C) have been developed for the determination of propranolol hydrochloride (PRO) in bulk drug and dosage forms. These methods are based on oxidation-bromination reaction of PRO by bromine, generated in situ by the action of acid on a bromate-bromide mixture, followed by determination of unreacted bromine by three different reaction schemes. In method A, the determination of the residual bromine is based on its ability to bleach the indigo carmine dye and by measuring the absorbance at 610 nm. The residual bromine (in method B), is treated with excess of iron(II) and the resulting iron(III) is complexed with thiocyanate and the absorbance is measured at 480 nm. Method C involves treating the unreacted bromine with a measured excess of iron(II) and the remaining iron(II) is complexed with 1,10-phenanthroline and the increase in absorbance is measured at 510 nm. In all three methods, the amount of bromine reacted corresponds to the drug content. The different experimental parameters affecting the development and stability of the colour are carefully studied and optimized. Beer's Law is valid within a concentration range of 1-13, 4-12 and 2-9 µg ml⁻¹ for methods A, B, and C, respectively. The molar absorptivity, Sandell's sensitivity, detection and quantification limits are calculated. Common excipients used as additives in pharmaceutical preparations do not interfere in the proposed methods. The proposed methods have been successfully applied to the determination of PRO in pharmaceutical preparations and the results were statistically compared with those of the official method by applying the Student's t-test and F-test.

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Simultaneous determination of paracetamol and penicillin V by square-wave voltammetry at a bare boron-doped diamond electrode

Švorc

Sochr

Tomčı́k

et al. 2012

Electrochimica Acta

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New way of application of the bromate–bromide mixture in kinetic analysis

Cited by 15 publications

References 19 publications

The acetylsalicylic acid-bromine system for multicomponent kinetic determinations

The acetylsalicylic acid-bromine system for multicomponent kinetic determinations

A sensitive spectrophotometric method for the determination of propranolol HCl based on oxidation bromination reactions

Simultaneous determination of paracetamol and penicillin V by square-wave voltammetry at a bare boron-doped diamond electrode

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