The acetylsalicylic acid-bromine system for multicomponent kinetic determinations

López-Cueto, Guillermo; Ostra, Miren; Ubide, Carlos

doi:10.1007/s00216-002-1533-2

Cited by 2 publications

(3 citation statements)

References 26 publications

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“…As we mentioned above, AcSA did not give any SWV signal on the surface of CPE, but it is common knowledge that it could be hydrolyzed on salicylic acid [58]. It has been published that a rapid hydrolysis (10 min, a boiling) proceeds at high pH (about 12) followed by neutral and acidic pH (about 2), where AcSA is the most stable [59].…”

Section: Resultsmentioning

confidence: 91%

Electrochemical Sensors for Detection of Acetylsalicylic Acid

Šupálková

Petřek

Havel

et al. 2006

Sensors

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Acetylsalicylic acid (AcSA), or aspirin, was introduced in the late 1890s and has been used to treat a variety of inflammatory conditions. The aim of this work was to suggest electrochemical sensor for acetylsalicylic detection. Primarily, we utilized square wave voltammetry (SWV) using both carbon paste electrode (CPE) and of graphite pencil electrode (GPE) as working ones to indirect determination of AcSA. The principle of indirect determination of AcSA bases in its hydrolysis on salicylic acid (SA), which is consequently detected. Thus, we optimized both determination of SA and conditions for AcSA hydrolysis and found out that the most suitable frequency, amplitude, step potential and the composition and pH of the supporting electrolyte for the determination of SA was 260 Hz, 50 mV, 10 mV and Britton-Robinson buffer (pH 1.81), respectively. The detection limit (S/N = 3) of the SA was 1.3 ng/ml. After that, we aimed on indirect determination of AcSA by SWV CPE. We tested the influence of pH of Britton-Robinson buffer and temperature on yield of hydrolysis, and found out that 100% hydrolysis of AcSA was reached after 80 minutes at pH 1.81 and 90°C. The method for indirect determination of AcSA has been utilized to analyse pharmaceutical drug. The determined amount of AcSA in Sensors 2006, 6 1484 the pharmaceutical drug was in good agreement with the declared amounts. Moreover, we used GPE for determination of AcSA in a pharmaceutical drug. Base of the results obtained from stationary electrochemical instrument we used flow injection analysis with electrochemical detection to determine of salicylates (SA, AcSA, thiosalicylic acid, 3,5-dinitrosalicylic acid and 5-sulfosalicylic acid -SuSA). We found out that we are able to determine all of detected salicylates directly without any pre-treatment, hydrolysis and so on at units of femtomoles per injection (5 µl).

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Section: Resultsmentioning

confidence: 91%

Electrochemical Sensors for Detection of Acetylsalicylic Acid

Šupálková

Petřek

Havel

et al. 2006

Sensors

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“…The use of bromine in kinetic spectrophotometric method is becoming of great interest [26][27][28] as it offered some advantages: The absorbance of bromine color decreases with time and hence, a kinetically based method is elaborated.…”

Section: − =mentioning

confidence: 99%

“…The absorbance of bromine color decreases with time and hence, a kinetically based method is elaborated. The use of bromine in kinetic spectrophotometric method is becoming of great interest [26][27][28] as it offered some advantages:…”

Section: Introductionmentioning

confidence: 99%

Development and validation of kinetic and atomic absorption spectrophotometric methods for the determination of salbutamol sulfate

et al. 2015

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Two sensitive kinetic and atomic absorption spectrophotometric (AAS) methodswhere developed for the determination of salbutamol sulfate (SLS) in its dosage forms. The kinetic method was based on the bromination reaction of the drug by bromine generated in-situ by the reaction of bromate with bromide in acidic medium.The reaction was followed spectrophotometrically by measuring the decrease of bromine color at 380 nm. The reaction was carefully studied and optimized. Under optimum conditions, the stoichiometry and the order of the reaction were determined.The initial rate and fixed time methods were utilized for the determination of salbutamol sulfate concentrations. The AAS method was depended on the oxidation of iron (II) with excess bromine from the bromination reaction of the drug. A new method for separation iron (III) was used. Then iron (II) in aqueous layer was aspirated into air-acetylene flame and determined by AAS. The linear ranges for the proposed methods were 2.0-10.0 and 0.2-2.0 µgmL -1 with detection limit of 0.30 and 0.012 µgmL -1 for kinetic and AAS, respectively. The proposed methods were validated; the mean recovery ranges from 98.0 to 102.0% with RSD < 2.1%. Common excipients did not interfere the measurements of SLS. The methods were successfully applied to determined SLS in dosage forms; there was no significant difference between the proposed methods and official one.

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The acetylsalicylic acid-bromine system for multicomponent kinetic determinations

Cited by 2 publications

References 26 publications

Electrochemical Sensors for Detection of Acetylsalicylic Acid

Electrochemical Sensors for Detection of Acetylsalicylic Acid

Development and validation of kinetic and atomic absorption spectrophotometric methods for the determination of salbutamol sulfate

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