Newlavirus, a Novel, Highly Prevalent, and Highly Diverse Protoparvovirus of Foxes (Vulpes spp.)

Canuti, Marta; Bouchard, Émilie; Rodrigues, Bruce; Whitney, Hugh; Hopson, Marti; Gilroy, Cornelia; Stenson, Garry B.; Dufour, Suzanne C.; Lang, Andrew S.; Verhoeven, Joost T. P.

doi:10.3390/v13101969

Cited by 7 publications

(13 citation statements)

References 45 publications

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“…Specifically, the strain found in the positive dog was highly identical to strains circulating in dogs in other areas of the world, while the strain found in foxes was a novel divergent variant. In addition, similar to what we observed with three different amdoparvoviral species (Canuti, McDonald et al., 2020), but different from what was observed for the protoparvovirus newlavirus (Canuti et al., 2021), we found CBuV in fox samples collected in only one of the two portions of the province. However, CBuV was only detected in stool samples of foxes from Labrador and no stool samples were available from Newfoundland foxes, introducing a possible sampling bias and highlighting the need for additional studies.…”

Section: Discussionsupporting

confidence: 87%

“…Only CPV-2 was found in both areas. Similar observations were made for other parvoviruses affecting these populations(Canuti et al, 2021;Canuti, McDonald TA B L E 1 Number (percentage) of animals and samples considered in this study that tested positive for parvoviruses…”

supporting

confidence: 76%

“…These 'old' CPV-2a/2b strains have been reported in the worldwide carnivoran population only until the 1980s and in dogs and wolves in Europe only in the 1990s (Battilani et al, 2019;Grecco et al, 2018;Miranda et al, 2017). The recent evidence of a CPV-2b strain with a similar amino acid pattern found in a sample collected in 2010 from a grey wolf from the Northwest territories, Canada (Canuti et al, 2021), suggests that these older CPV-2 strains persist in wildlife as well as in domestic dogs, at least in North America. These older CPV-2a strains co-circulate in Newfoundland with 'new CPV-2a/2b' strains, suggesting that the CPV-2 population in this area is heterogeneous.…”

Section: Parvoviruses In Free-roaming and Domestic Dogsmentioning

confidence: 91%

“…Scientific research permits were provided by the Government of Newfoundland and Labrador and the Nunatsiavut Government where required (WLR2018‐39, WLR2018‐40, WLR2018‐43, WLR2019‐45) and the study was carried out in accordance with guidelines of the Canadian Council on Animal Care, with approved protocols (14‐04‐AL, 15‐04‐AL and 20‐04‐AL) from the Memorial University Institutional Animal Care Committee. All samples were previously used for other studies (Bouchard et al., 2022; Canuti et al., 2017, 2021; Canuti, McDonald et al., 2020).…”

Section: Methodsmentioning

confidence: 99%

“…CPV-2: canine parvovirus 2; CBoV-2: canine bocavirus 2; CBuV: canine bufavirus; CachaV-1: cachavirus 1; MVC: minute virus of canines; AMDV: Aleutian mink disease virus; LaAV: Labrador amdoparvovirus; NA: not available. Labrador (Canuti et al, 2021) while three amdoparvoviral species were restricted to one of the two regions (Canuti, McDonald et al, 2020) (Table 1). CBuV was the only virus found in two different host species (fox and dog) in the same area.…”

Section: Positivity Rates and Distributionmentioning

confidence: 99%

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Distribution and diversity of dog parvoviruses in wild, free‐roaming and domestic canids of Newfoundland and Labrador, Canada

Canuti

Mira

Sorensen

et al. 2022

Transbounding Emerging Dis

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Some parvoviruses of carnivorans can infect multiple host species. Since many canine parvoviruses were only discovered recently, their host-range is still unexplored. We examined the host distribution and diversity of five dog parvoviruses in four canine populations from Newfoundland and Labrador, Canada, and investigated the potential for these viruses to cross the species barriers. Canine bocavirus 2 (CBoV-2) and the minute virus of canines were detected in stool from free-roaming dogs from Labrador (5/48 [10.4%] and 3/48 [6.3%], respectively) and two different CBoV-2 variants were identified. Canine bufavirus was identified in stool from free-roaming dogs (1/48, 2.1%) and foxes (3/80, 3.8%) from Labrador, but two different variants were observed in the two host species. The variant found in foxes was highly divergent from previously identified strains. Two cachavirus 1 variants, genetically similar to those circulating in other Canadian wildlife, were found in spleens from Newfoundland coyotes (3/87, 3.5%).Canine parvovirus type 2 (CPV-2) was found in stool from free-roaming dogs from Labrador (2/48, 4.2%) and in spleens from Newfoundland coyotes (3/87, 3.5%). Comparing CPV-2 sequences from these hosts to those retrieved from local symptomatic domestic dogs revealed the presence of a highly heterogeneous viral population as detected strains belonged to five different clades. The close relationship between CPV-2a strains from a dog and a coyote suggests the occurrence of viral transfer between wild and domestic canids. The identification of highly related strains with a similar molecular signature characteristic of older CPV-2 strains in free-roaming and domestic dogs suggests a probable common ancestry and that older CPV-2 strains, which have not been identified in dogs since the 1990s, persist in this part of Canada. Followup studies should evaluate samples from a larger number of animals and host species to extensively investigate the possible occurrence of cross-species transmission for recently discovered parvoviruses.

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Section: Discussionsupporting

confidence: 87%

supporting

confidence: 76%