News and meta-analysis regarding anti-Beta 2 glycoprotein I antibodies and their determination

Bettacchioli, Éléonore; Salma, Nafai; Renaudineau, Yves

doi:10.1016/j.clim.2019.06.002

Cited by 8 publications

(5 citation statements)

References 142 publications

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“…Tissue-specific genes are a kind of gene that are specifically expressed in certain tissues. Previous studies have found that these adipose tissue-specific genes have various functions, such as lipid transport (β 2 GP1) [48], fat synthesis (CIDE3) [49], lipolysis (HSL, NCEH1) [50][51][52][53], calcium metabolism, cell proliferation and apoptosis (CAMK1G) [54,55], protective cells (KRT222) [56,57] and antioxidant (FAM213A) [58,59]. Identifying the specificity of adipose genes is important for understanding the development and regulation of adipose tissue.…”

Section: Discussionmentioning

confidence: 99%

Validation and Functional Analysis of Reference and Tissue-Specific Genes in Adipose Tissue of Freshwater Drum, Aplodinotus grunniens, under Starvation and Hypothermia Stress

Xue

Huang

et al. 2023

Cells

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Adipose tissue is critical to the growth, development, and physiological health of animals. Reference genes play an essential role in normalizing the expression of mRNAs. Tissue-specific genes are preferred for their function and expression in specific tissues or cell types. Identification of these genes contributes to understanding the tissue–gene relationship and the etiology and discovery of new tissue-specific targets. Therefore, reference genes and tissue-specific genes in the adipose tissue of Aplodinotus grunniens were identified to explore their function under exogenous starvation (1 d, 2 w, 6 w) and hypothermic stress (18 °C and 10 °C for 2 d and 8 d) in this study. Results suggest that 60SRP was the most stable reference gene in adipose tissue. Meanwhile, eight genes were validated as tissue-specific candidates from the high-throughput sequencing database, while seven of them (ADM2, β2GP1, CAMK1G, CIDE3, FAM213A, HSL, KRT222, and NCEH1) were confirmed in adipose tissue. Additionally, these seven tissue-specific genes were active in response to starvation and hypothermic stress in a time- or temperature-dependent manner. These results demonstrate that adipose-specific genes can be identified using stable internal reference genes, thereby identifying specific important functions under starvation and hypothermic stress, which provides tissue-specific targets for adipose regulation in A. grunniens.

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Section: Discussionmentioning

confidence: 99%

Validation and Functional Analysis of Reference and Tissue-Specific Genes in Adipose Tissue of Freshwater Drum, Aplodinotus grunniens, under Starvation and Hypothermia Stress

Xue

Huang

et al. 2023

Cells

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“…90 When these autoantibodies bind to β 2 GPI it dimerizes and induces an inflammatory and a pro-thrombotic response. 91 It was demonstrated that in LDLR −/− mice, β 2 GPI and CD4 lymphocytes are present on lesions and are abundant in the subendothelial space. 92 Furthermore, it was shown that ApoE −/− mice immunized against β 2 GPI developed atherosclerotic lesions in the aortic sinus and had elevated levels of CD4+ and to a lesser degree CD8+ lymphocytes.…”

Section: Oxidized Low-density Lipoprotein (Oxldl)mentioning

confidence: 99%

“…Many studies have reported that the interaction between the anti‐β 2 GPI autoantibodies with β 2 GPI leads to the development of certain diseases, such as antiphospholipid syndrome (APS) or atherosclerosis 90 . When these autoantibodies bind to β 2 GPI it dimerizes and induces an inflammatory and a pro‐thrombotic response 91 . It was demonstrated that in LDLR −/− mice, β 2 GPI and CD4 lymphocytes are present on lesions and are abundant in the subendothelial space 92 .…”

Section: Introductionmentioning

confidence: 99%

Fatal attractions that trigger inflammation and drive atherosclerotic disease

Sharma,

Mossman,

Austin

2024

Eur J Clin Investigation

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BackgroundAtherosclerosis is the salient, underlying cause of cardiovascular diseases, such as arrhythmia, coronary artery disease, cardiomyopathy, pulmonary embolism and myocardial infarction. In recent years, atherosclerosis pathophysiology has evolved from a lipid‐based to an inflammation‐centric ideology.MethodsThis narrative review is comprised of review and original articles that were found through the PubMed search engine. The following search terms or amalgamation of terms were used: “cardiovascular disease,” “atherosclerosis,” “inflammation,” “GRP78,” “Hsp60,” “oxidative low‐density lipoproteins,” “aldehyde dehydrogenase,” “β2‐glycoprotein,” “lipoprotein lipase A,” “human cytomegalovirus.” “SARS‐CoV‐2,” “chlamydia pneumonia,” “autophagy,” “thrombosis” and “therapeutics.”ResultsEmerging evidence supports the concept that atherosclerosis is associated with the interaction between cell surface expression of stress response chaperones, including GRP78 and Hsp60, and their respective autoantibodies. Moreover, various other autoantigens and their autoantibodies have displayed a compelling connection with the development of atherosclerosis, including oxidative low‐density lipoproteins, aldehyde dehydrogenase, β2‐glycoprotein and lipoprotein lipase A. Atherosclerosis progression is also concurrent with viral and bacterial activators of various diseases. This narrative review will focus on the contributions of human cytomegalovirus as well as SARS‐CoV‐2 and chlamydia pneumonia in atherosclerosis development. Notably, the interaction of an autoantigen with their respective autoantibodies or the presence of a foreign antigen can enhance inflammation development, which leads to atherosclerotic lesion progression.ConclusionWe will highlight and discuss the complex role of the interaction between autoantigens and autoantibodies, and the presence of foreign antigens in the development of atherosclerotic lesions in relationship to pro‐inflammatory responses.

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“…After routine serum separation, ANA was detected by indirect immunofluorescence assay kit (EUROIMMUN, Germany) and ANCA and ACA were detected by ELISA kit (Elabscience). Reference standard for positive antibody [6][7][8] : (1) ANA positive standard: titer ≥1:100; (2) ACA positive standard: immunoglobulin IgM>1.56 U/ml, IgA>1.24 U/ml, IgG>1.42 U/ml;…”

Section: Thismentioning

confidence: 99%

Relations between antinuclear, antineutrophil cytoplasmic, anticardiolipin antibodies and degree of neurological deficit, cerebrovascular stenosis in cerebral infarction patients

Meng¹,

Xing²,

Zhang³

et al. 2023

Pak J Med Sci

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Objective: To investigate the correlation of antinuclear antibody (ANA), antineutrophil cytoplasmic antibody (ANCA) and anticardiolipin antibody (ACA) with the degree of the neurological defect and cerebrovascular stenosis in patients with cerebral infarction. Methods: Clinical data of 99 patients with acute cerebral infarction (ACI) admitted to the Department of Neurology of Baoding First Central Hospital from June 2020 to December 2021 were retrospectively analyzed, and their ANA, ACA, ANCA, neurological deficit (NIHSS) scores as well as cerebrovascular stenosis were detected and assessed. Moreover, the correlation between the positive expression rates of ANA, ANCA, ACA and the degree of the neurological deficit, as well as the location and degree of cerebrovascular stenosis, were analyzed. Results: All patients had ANA, ACA, ANCA antibodies with positive rates of 68.69%, 70.71%, 69.70%, and mild, moderate, and severe cerebrovascular stenosis with incidence rates of 28.28%, 32.32%, and 39.39% respectively; Moreover, their incidence of mild, moderate, and severe neurological deficits were 15.15%, 44.44%, and 40.40%, respectively. Statistically significant differences could be observed in the degree of cerebrovascular stenosis and neurological deficit between the ANA, ACA and ANCA antibody positive group and the negative group (p<0.05). ANA, ACA, ANCA antibody positive was moderately positively correlated with cerebrovascular stenosis rate and NIHSS score (0.40<r<0.60, p<0.05). Conclusions: The positive rates of ANA, ACA and ANCA antibodies were higher in patients with ACI, which was closely correlated with the degree of cerebrovascular stenosis and neurological deficit. doi: https://doi.org/10.12669/pjms.39.3.6765 How to cite this: Meng H, Xing X, Zhang C, Zhao J, Ren C, Liu Y. Relations between antinuclear, antineutrophil cytoplasmic, anticardiolipin antibodies and degree of neurological deficit, cerebrovascular stenosis in cerebral infarction patients. Pak J Med Sci. 2023;39(3):677-681. doi: https://doi.org/10.12669/pjms.39.3.6765 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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News and meta-analysis regarding anti-Beta 2 glycoprotein I antibodies and their determination

Cited by 8 publications

References 142 publications

Validation and Functional Analysis of Reference and Tissue-Specific Genes in Adipose Tissue of Freshwater Drum, Aplodinotus grunniens, under Starvation and Hypothermia Stress

Validation and Functional Analysis of Reference and Tissue-Specific Genes in Adipose Tissue of Freshwater Drum, Aplodinotus grunniens, under Starvation and Hypothermia Stress

Fatal attractions that trigger inflammation and drive atherosclerotic disease

Relations between antinuclear, antineutrophil cytoplasmic, anticardiolipin antibodies and degree of neurological deficit, cerebrovascular stenosis in cerebral infarction patients

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