NF-κB and Nrf2 as prime molecular targets for chemoprevention and cytoprotection with anti-inflammatory and antioxidant phytochemicals

Surh, Young‐Joon; Na, Hye-Kyung

doi:10.1007/s12263-007-0063-0

Cited by 209 publications

(162 citation statements)

References 30 publications

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“…RES showed anti-inflammatory activities by the inhibition of 655 NF-κB activity via multiple mechanisms (Surh and Na, 2008). RES inhibited HSV replication 656 by suppressing NF-κB activity (Faith et al, 2006).…”

Section: Effect Of Res and Liposomal Res On Tnf-α And Il-1β Productiomentioning

confidence: 99%

Resveratrol-loaded liposomes for topical treatment of the vaginal inflammation and infections

Jøraholmen

Škalko‐Basnet

Acharya

et al. 2015

European Journal of Pharmaceutical Sciences

109

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Resveratrol (RES), chemically known as 3,5,4'-trihydroxy-transstilbene, is a promising multi-targeted anti-oxidative and antiinflammatory natural polyphenol. Preclinical studies showed its biological activities against the pathogens of sexually transmitted diseases causing vaginal inflammation and infections. Due to its low solubility and poor bioavailability, the optimal therapeutic uses are limited. Therefore, a clinically acceptable topical vaginal formulation of RES exhibiting optimal therapeutic effects is highly desirable. For this purpose, we prepared and optimized chitosan-coated liposomes with RES. The coated vesicles (mean diameter 200 nm) entrapped up to 77% of RES, a sufficient load to assure required therapeutic outcome. In vitro drug release study showed the ability of liposomes to provide sustained release of RES. In vitro anti-oxidative activities of RES, namely DPPH and ABTS*+ radicals scavenging assays, confirmed RES to be as potent as standard anti-oxidants, vitamins C and E. The anti-oxidative activities of RES and its corresponding liposomal formulation were also compared by measuring enhanced superoxide dismutase (SOD) activities in lipopolysaccharide (LPS)-induced J774A.1 cells. In vitro antiinflammatory activities were compared by measuring nitric oxide (NO), tumor necrosis factor (TNF)-α and interleukin (IL)-1β production in LPSinduced J774A.1 cells. Liposomal RES was found to exhibit stronger antioxidative and anti-inflammatory activities than RES solution. Resveratrol (RES), chemically known as 3,5,4'-trihydroxy-trans-stilbene, is a 18 promising multi-targeted anti-oxidative and anti-inflammatory natural polyphenol. Preclinical 19 studies showed its biological activities against the pathogens of sexually transmitted diseases 20 causing vaginal inflammation and infections. Due to its low solubility and poor 21 bioavailability, the optimal therapeutic uses are limited. Therefore, a clinically acceptable 22 topical vaginal formulation of RES exhibiting optimal therapeutic effects is highly desirable. 7Corrections were made accordingly as mentioned on page 8, lines 210-217. 8 9Please discuss the possibility for using other polymers instead of chitosan. 11Some discussion was added on page 18, lines 551-555 12 13Spelling error -page 7, section 2.7., should be "Characterization…" instead of

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Section: Effect Of Res and Liposomal Res On Tnf-α And Il-1β Productiomentioning

confidence: 99%

Resveratrol-loaded liposomes for topical treatment of the vaginal inflammation and infections

Jøraholmen

Škalko‐Basnet

Acharya

et al. 2015

European Journal of Pharmaceutical Sciences

109

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“…Кроме того, известно, что окислительный стресс ведет к накоплению фактора Nrf2 в ядре клетки [61]. Это связывают с чувствительностью ингибиторного белка Keap1 к изменению потенциала клетки благодаря наличию у него нескольких высоко реактивных цистеиновых остатков [53,62]. Структура белка Keap1 предполагает также возможность модуляции его нуклеофильных тиоловых групп электрофильными молекулами [63].…”

Section: ãëóòàòèîí-S-òðàíñôåðàçà Nad(p)hunclassified

Mechanisms of plant polyphenols anti-cancer effects I. Blockade of carcinogenesis initiation

Spasov

2012

BIOMED KHIM

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Mechanisms of anti-cancer effects of polyphenols, found in fruits, vegetables, spices and representing parts of daily nutrition, have been considered. These compounds may be the basis for development of cancer preventive preparations. They can block carcinogenesis initiation by inactivation of exogenous or endogenous genotoxic molecules including reactive oxygen species. Another mechanism consists in inhibition of activity and synthesis of carcinogen-metabolizing enzymes. Plant polyphenols also induce expression of antioxidant and detoxification enzymes genes.

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“…The transcription of many detoxifying enzymes is regulated through the antioxidant response element (ARE), whose transcription factor, Nrf2, is repressed under basal conditions by Keap1 (24,74,75). Dietz et al, 2008, described how extracts from the roots of Angelica sinensis, induced the detoxiˆcation enzyme NAD(P)H: quinone oxidoreductase 1 (NQO1) by alkylating Keap1.…”

Section: Examples Of Mechanisms Of Anti-mutagen Protection Against DImentioning

confidence: 99%

Antimutagenesis Studies: Where Have They Been and Where Are They Heading?

Ferguson

2011

Genes and Environment

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An anti-mutagen is any substance that reduces the rate of spontaneous mutations or counteracts or reverses the action of a mutagen, or any technique that protects cells against the eŠects of mutagens. Studies as early as the 1940s reported on substances that delayed detection of radiation-induced mutations, or reduced the appearance of mutations induced by chemicals such as acridine orange. However, a far more sophisticated range of anti-mutagens is now being identiˆed. Mutagen scavengers act through absorption onto a larger molecule that is readily excreted. Good examples are provided by dietaryˆbre sources, such as wheat bran, or the planar molecule, chlorophyll and its stabilised derivative, chlorophyllin. Mutagens may be actively extruded from human cells through the action of one or more of a series of ATP-binding cassette (ABC) drug transporter proteins, including the multidrug resistance proteins (P-glycoproteins), multidrug resistance-associated proteins (MRP1-7) and the breast cancer resistance protein (BCRP). These proteins can aŠect the absorption, distribution and excretion of mutagens and carcinogens, as well as of their metabolites and conjugates. Even if the undesirable compound enters the cells, there are several mechanisms by which it may be prevented from interaction with DNA. Detoxiˆcation mechanisms are of increasing interest, especially those where transcription is regulated through the antioxidant response element (ARE), whose own transcription factor, Nrf2, is repressed under basal conditions. While much of the early literature on mutagenesis and carcinogenesis implicated exogenous chemicals, it is increasingly realised that unrepaired oxidative DNA lesions are important mutational precursors, and anti-oxidants represent an important class of anti-mutagens. It is also recognised that deˆciency of certain micronutrients may lead to cell mutation, and that restoring nutrient balance is an important mechanism of antimutagenesis. An increasing number of studies focus on DNA repair and stress responses as novel mechanisms of anti-mutagenesis.

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NF-κB and Nrf2 as prime molecular targets for chemoprevention and cytoprotection with anti-inflammatory and antioxidant phytochemicals

Cited by 209 publications

References 30 publications

Resveratrol-loaded liposomes for topical treatment of the vaginal inflammation and infections

Resveratrol-loaded liposomes for topical treatment of the vaginal inflammation and infections

Mechanisms of plant polyphenols anti-cancer effects I. Blockade of carcinogenesis initiation

Antimutagenesis Studies: Where Have They Been and Where Are They Heading?

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