“…3 To accomplish this objective, we focused on activating alcohol, amine, or thiol precursors with commercially available thiocarbonyl sources (carbon disulfide (CS 2 ) or 1,1′thiocarbonyldiimidazole (TCDI)) for the development of a Ni-catalyzed Negishi cross-coupling. 3 For thionoester synthesis, O-alkyl xanthate esters derived from tertiary (79a), secondary (79b, 79c, 79f, 79g), or primary (79d, 79e) aliphatic alcohols could be efficiently coupled to both electron-rich (79h, 79j) and electron-deficient (79i) (hetero)arylzinc reagents (Scheme 14a). As observed with our previous reports, ortho-substituted arylzinc reagents gave low yields of the desired product.…”