Nickel Content of Plasma, Urine and Hair in Contact Dermatitis

Spruit, D.; Bongaarts, Peter

doi:10.1159/000251084

Cited by 33 publications

(10 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2). Ingestion of an additional 5 mg Ni2 + (nickel sulphate solution) was studied in the volun- teer with and without simultaneous ingestion of DDC, the 5 mg Ni 2 + increased the nickel concentration in his urine within a few hours from about 1 to about 10 f.lg Ni/1 similarly to an identical increase in the nickel concentration of his blood plasma (Spruit & Bongaarts 1977). With simultaneous ingestion of DDC the 5 mg Ni2+ increased the nickel concentration to 100-200 f.lg Ni/1 urine within a few hours (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…The sampling of urine has been described in a previous article in this journal . Nickel concentrations in urine and hair were determined by a direct analysis with a Varian AA5 and CRA63 electrothermal atomic absorption spectrometer with a BC6 simultaneous background corrector (Spruit & Bongaarts 1977). The calculation of nickel concentration in 24-h urines and the evaluation of the activity of the eczema have been described before .…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Dithiocarbamate therapy for nickel dermatitis

1978

View full text Add to dashboard Cite

Increased internal exposure to nickel can cause an exacerbation of nickel contact dermatitis. Nickel ions are chelated by diethyldithiocarbamate (DDC) and thereby inactivated. An oral dose of about 1 g DDC/day was given to a patient. The nickel excretion in the urine increased about tenfold; the nickel elimination in scalp hair did not increase. The slightly negative nickel balance did not exhaust the nickel content of the organs appreciably with a dose of 1.2 g DDC/day for 2 months. At the end of this experiment patch tests with nickel sulphate were still positive though less local therapy was needed, and the cross correlation between the activity of the eczema and the nickel concentration in the urine had lost its former periodicity. It is therefore not yet possible to conclude whether or not DDC may be really of help in the very nickel hypersensitive patient by reducing the exposure to nickel originating in food and other environmental sources.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Dithiocarbamate therapy for nickel dermatitis

1978

View full text Add to dashboard Cite

show abstract

“…These authors concluded that the nickel content of serum and urine depend on environmental nickel. In a recent study, Spruit & Bongaarts (1977) demonstrated increased urinary nickel for more than 24 h following the administration of 5.0 mg. nickel to two healthy volunteers. In the present study, the oral administration of 5.6 mg. nickel was followed by an increased nickel excretion over 2-3 days.…”

Section: Methodsmentioning

confidence: 96%

Nickel excretion in urine after oral administration*

1978

View full text Add to dashboard Cite

In recent years the importance of internal exposure to nickel in patients with recurrent hand eczema and nickel allergy has become evident. The present study was performed in order to investigate the value of urinary nickel determinations as an index of oral nickel intake. After oral administration of 5.6 mg nickel (as the sulfate), increased nickel excretion was found over the following 2-3 days. We conclude that consecutive urinary nickel determinations are able to disclose variations in oral intake of nickel.

show abstract

“…These findings were confirmed by others for manganese" and nickel. [9][10][11] For cOfper, other studies either confirrned/' H, 9, 12, L or found no sex difference.J'"!" However, some of these studies examined only special groups, e.g.…”

Section: Sexmentioning

confidence: 99%