Nickel (II) chloride schiff base complex: Synthesis, characterization, toxicity, antibacterial and leishmanicidal activity

Maia, Danielle O.; Santos, Valdenice F.; Barbosa, Cristina R.S.; Fróes, Yuri Nascimento; Muniz, Débora Feitosa; Santos, Ana L.E.; Santos, Maria H.C.; Silva, Romério R.S.; Silva, Cláudio G.L.; Souza, Racquel O.S.; Sousa, Joicy Cortez Sá; Coutinho, Henrique D.M.; Teixeira, Claudener S.

doi:10.1016/j.cbi.2021.109714

Cited by 12 publications

(2 citation statements)

References 59 publications

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“…The Schiff bases play a key role in medicinal chemistry and are a target substance for many synthetic proposals due to their beneficial properties. [ 1 ] Schiff bases, which have a variety of donor sites and a chelating inclination toward a variety of metal ions, have shown to be useful ligands in the medical profession, including diagnostics. Antibacterial, antifungal, antidiabetic, antitumor, antiproliferative, anticancer, anticorrosive, and anti‐inflammatory effects are among the biological activities of Schiff bases.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, spectroscopic, DFT calculations, antimicrobial, cytotoxicity, and DNA binding studies of novel Cu (II), Ni (II), Zn (II), and VO (II) Schiff base complexes based on ibuprofen

Abdel‐Rahman

Abdel‐Mawgoud

Mohamed

et al. 2022

Applied Organom Chemis

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The ibuprofen Schiff base ligand (HL) [HL=2-(4-Isobutyl-phenyl)-propionic acid (3-hydroxy-naphthalen-2-ylmethylene)-hydrazide] and its Cu (II), Ni (II), Zn (II), and VO (II) chelates were synthesized and characterized. The spectral data revealed that the Schiff base ligand HL coordinated to Cu (II), Ni (II), Zn (II), and VO (II) via azomethine nitrogen and phenolic oxygen. NiL and CuL have square planar geometry, ZnL has octahedral geometry, and VOL has square pyramidal geometry. Density functional calculations (DFT) were performed to examine the molecular geometry. The results of continuous variation and molar ratio methods supported the ratio of (M:L) to be (1:1). The antimicrobial activity of the new Ibuprofen Schiff base ligand and its metal complexes was tested in vitro against bacterial pathogens and fungi. The results revealed that the antimicrobial efficacy follows the order: CuL is the highly inhibitor complex compared with ketoconazole and gentamicin as reference drugs. The in vitro cytotoxic activity of the new ligand and its complexes was also investigated against Hep-G2, MCF-7, and HCT-116 cell lines. The results showed again that CuL is the highest active agent compared with Vinblastine drug. The CT-DNA binding ability of the studied complexes was evaluated by absorption spectroscopic titrations and gel electrophoresis. The results showed that the complexes have good binding propensity, and their binding constant values were from 3.1 Â 10 5 to 6.1 Â 10 5 M À1 .

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Section: Introductionmentioning

confidence: 99%

Synthesis, spectroscopic, DFT calculations, antimicrobial, cytotoxicity, and DNA binding studies of novel Cu (II), Ni (II), Zn (II), and VO (II) Schiff base complexes based on ibuprofen

Abdel‐Rahman

Abdel‐Mawgoud

Mohamed

et al. 2022

Applied Organom Chemis

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“…Maia et al, (2022) [ 66 ] recently described the synthesis of a nickel(II) chloride SB complex [(Ni(L2), 13 ] and its antimicrobial activity evaluation against multi-resistant S. aureus 10 (from catheter tip), E. coli 06 (from urine culture) and P. aeruginosa 15 (from rectal swab) strains and leishmania. This complex showed inhibition of the bacterial growth for the strains of P. aeruginosa , at the concentration of 256 μg/mL, while it was not active against E. coli and S. aureus (MIC ≥ 1024 μg/mL).…”

Section: Mononuclear Sbs Complexesmentioning

confidence: 99%

Metal Complexes with Schiff Bases: Data Collection and Recent Studies on Biological Activities

Sinicropi

Ceramella

Iacopetta

et al. 2022

IJMS

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Metal complexes play a crucial role in pharmaceutical sciences owing to their wide and significant activities. Schiff bases (SBs) are multifaceted pharmacophores capable of forming chelating complexes with various metals in different oxidation states. Complexes with SBs are extensively studied for their numerous advantages, including low cost and simple synthetic strategies. They have been reported to possess a variety of biological activities, including antimicrobial, anticancer, antioxidant, antimalarial, analgesic, antiviral, antipyretic, and antidiabetic ones. This review summarizes the most recent studies on the antimicrobial and antiproliferative activities of SBs-metal complexes. Moreover, recent studies regarding mononuclear and binuclear complexes with SBs are described, including antioxidant, antidiabetic, antimalarial, antileishmanial, anti-Alzheimer, and catecholase activities.

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Recent Progress in Metal‐Incorporated Acyclic Schiff‐Base Derivatives: Biological Aspects

et al. 2022

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Schiff-base derivatives are widely used organic compounds and their metal complexes have been drawing much attention to chemists due to interesting structural features and unique properties. The presence of nitrogen containing imine groups (À C=NÀ ) in Schiff-bases as well as in their metallic complexes and the chelating properties of these compounds are responsible for their many unique biological properties. In this review, we have summarized various acyclic Schiff-base ligands and their different metallic complexes which have been reported in the last one decade. Schiff-bases and their metal complexes have shown a broad range of biological activities, including antifungal, antibacterial, antimalarial, antiproliferative, antiinflammatory, antiviral, and antipyretic properties. We have reviewed and arranged the reported Schiff-base derivatives according to their diverse biological applications, especially their anti-bacterial and anti-fungal activities, anti-tumor and anti-cancer activities, anti-oxidant activities, anti-inflammatory activities and other therapeutic and medicinal properties. The other component of this work as a review of the molecular structures of various Schiff-bases since their molecular structures play a primary role in the biological properties. The presence of heteroatoms such as nitrogen, sulfur and oxygen with free electron pairs and aromatic rings in the structure of the Schiff-bases play significant roles in determining their properties.

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Nickel (II) chloride schiff base complex: Synthesis, characterization, toxicity, antibacterial and leishmanicidal activity

Cited by 12 publications

References 59 publications

Synthesis, spectroscopic, DFT calculations, antimicrobial, cytotoxicity, and DNA binding studies of novel Cu (II), Ni (II), Zn (II), and VO (II) Schiff base complexes based on ibuprofen

Synthesis, spectroscopic, DFT calculations, antimicrobial, cytotoxicity, and DNA binding studies of novel Cu (II), Ni (II), Zn (II), and VO (II) Schiff base complexes based on ibuprofen

Metal Complexes with Schiff Bases: Data Collection and Recent Studies on Biological Activities

Recent Progress in Metal‐Incorporated Acyclic Schiff‐Base Derivatives: Biological Aspects

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