Nickel(II) complexes from phosphor-dichalcogenide (P/Se2 and P/S2) type ligands: Synthesis, structure and theoretical calculations

Yusuf, Tunde L.; Ibeji, Collins U.; Zyl, Werner E. van

doi:10.1016/j.molstruc.2020.128517

Cited by 10 publications

(6 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The N — S bond distances and S — Ni — S bond angles are compatible with those previously found in dithiophosphonato Ni(II) complexes. [ 35,40,64–70 ] The average P — S bond lengths for [Ni(Ln) 2 ] are typically about 2.0 Å, which shows that π‐electron delocalization prevails in the ‐PS 2 moiety of dithiophosphonates. These values are consistent with the literature reports.…”

Section: Resultsmentioning

confidence: 99%

“…The selected bond lengths and bond angles are given in Table S7. The Ni-S bond distances in Ni(II) coordination sphere are between 2.2148( 13 [35,40,[64][65][66][67][68][69][70] The average P-S bond lengths for [Ni(Ln) 2 ] are typically about 2.0 Å, which shows that π-electron delocalization prevails in the -PS 2 moiety of dithiophosphonates. These values are consistent with the literature reports.…”

Section: Crystallographic Descriptions Of the Ni(ii) Complexesmentioning

confidence: 99%

“…[34][35][36] Ni(II) complexes are well-known among the four coordinate metal complexes. [37][38][39][40] S-tributylstannyl dithiophosphates and dithiophosphonates were prepared, and the bactericidal activity of S-tributylstannyl dithiophosphates was tested on Staphylococcus aureus (ATCC 29213), Escherichia сoli (ATCC 25922), and Bacillus cereus. [41] These compounds tested had more activity towards B. cereus than control Nika-Politsid (10 mm) and Slayt (12 mm) with growth inhibition zone of 23-24 mm.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Ni(II) complexes with 1,3,2,4‐dithiadiphosphetane 2,4‐disulfide‐based ligands: Structural insights, theoretical studies, and anticancer activities

Bulat

Sağlam

Zeyrek

et al. 2022

Applied Organom Chemis

View full text Add to dashboard Cite

The first synthesis of 2,4‐bis(3,4‐dimethoxyphenyl)‐1,3‐dithia‐2,4‐diphosphetane 2,4‐disulfide (SAV‐A1 reagent) was achieved. Seven oxo‐alkyl esters (HLn) were synthesized thereof. Ni(II) complexes ([Ni(Ln)2]) of these ligands were prepared in ethanol. The structures were identified by spectral studies. Ni(II) complexes were unambiguously determined by X‐ray crystallography. In addition, the ligands and their Ni(II) complexes were tested on two different human cancer cell lines, including liver and colon. Moreover, density functional theory (DFT) calculations of the Ni(II) complexes were performed, and the molecular docking studies of these compounds with liver cancer protein, PDB ID: 3WZE and colon cancer antigen proteins, ID 2HQ6 were presented to investigate and predict potential interactions.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Crystallographic Descriptions Of the Ni(ii) Complexesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ni(II) complexes with 1,3,2,4‐dithiadiphosphetane 2,4‐disulfide‐based ligands: Structural insights, theoretical studies, and anticancer activities

Bulat

Sağlam

Zeyrek

et al. 2022

Applied Organom Chemis

View full text Add to dashboard Cite

show abstract

“…67 The synergy between this functional and basis set has been reported 69 to be suitable for compounds containing metal ions. 70 True energy minima were verified by performing frequency calculation for all complexes with no indication of imaginary frequencies. The complexes were optimized in gas phase.…”

Section: Methodsmentioning

confidence: 99%

The effect of structural configuration on the DNA binding andin vitroantioxidant properties of new copper(ii) N₂O₂Schiff base complexes

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Group 10 metal cations, on the other hand, give rise to mononuclear monomeric complexes with a square planar coordination neighbourhood [21]. Ni(II) complexes are the most familiar of the square planar metal(II)-DTPOAs [22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Studies on new dithiophosphonic acid derivatives: Synthesis, characterization, DFT and molecular docking calculations and in vitro cytotoxicity assessment

Bulat,

Sağlam,

Akkoç

et al. 2024

Preprint

View full text Add to dashboard Cite

2,4-bis(3,4-dimethoxyphenyl)-1,3-dithia-2,4-diphosphetane 2,4-disulfide (SAV-A1) was treated with five different alcohols to obtain dithiophosphonic acids (HLn, HS2P((2,4-CH3O)2-C6H3)(ORn); n=1-5, R1=n-pentyl-; R2=2-pentyl-; R3=4-tert-but-benzyl-; R4=2-propyl-; R5=2-butyl-). HLn series were converted to their ammonium salts, ([NH4Ln]). [NH4Ln] were reacted with NiCl2.6H2O to obtain the corresponding Ni(II) coordination compounds ([Ni(Ln)2]) in ethanol medium. The structures of all the compounds were elucidated by spectroscopic techniques. Single-crystal X-ray diffraction analysis of [Ni(L1)2], [Ni(L2)2], [Ni(L4)2] and [Ni(L5)2] were also carried out. The ligands and their nickel complexes were tested on human liver and colon cancer cell lines using (MTT) assay method. The salts [NH4L2] and [NH4L5] demonstrated more antiproliferative effects than others in colon cancer cell line with IC50 values 82.73 and 74.87 µM, respectively. Density Functional Theory (DFT) calculations of [Ni(L1)2], [Ni(L2)2], [Ni(L4)2] and [Ni(L5)2] were done. The molecular docking studies of [Ni(L1)2], [Ni(L2)2], [Ni(L4)2] and [Ni(L5)2] with colon cancer antigen proteins, ID 2HQ6 and liver cancer protein, PDB ID: 3WZE were done to foresee the interactions of the complexes.

show abstract

Nickel(II) complexes from phosphor-dichalcogenide (P/Se2 and P/S2) type ligands: Synthesis, structure and theoretical calculations

Cited by 10 publications

References 52 publications

Ni(II) complexes with 1,3,2,4‐dithiadiphosphetane 2,4‐disulfide‐based ligands: Structural insights, theoretical studies, and anticancer activities

Ni(II) complexes with 1,3,2,4‐dithiadiphosphetane 2,4‐disulfide‐based ligands: Structural insights, theoretical studies, and anticancer activities

The effect of structural configuration on the DNA binding andin vitroantioxidant properties of new copper(ii) N₂O₂Schiff base complexes

Studies on new dithiophosphonic acid derivatives: Synthesis, characterization, DFT and molecular docking calculations and in vitro cytotoxicity assessment

Contact Info

Product

Resources

About

Nickel(II) complexes from phosphor-dichalcogenide (P/Se2 and P/S2) type ligands: Synthesis, structure and theoretical calculations

Cited by 10 publications

References 52 publications

Ni(II) complexes with 1,3,2,4‐dithiadiphosphetane 2,4‐disulfide‐based ligands: Structural insights, theoretical studies, and anticancer activities

Ni(II) complexes with 1,3,2,4‐dithiadiphosphetane 2,4‐disulfide‐based ligands: Structural insights, theoretical studies, and anticancer activities

The effect of structural configuration on the DNA binding andin vitroantioxidant properties of new copper(ii) N2O2Schiff base complexes

Studies on new dithiophosphonic acid derivatives: Synthesis, characterization, DFT and molecular docking calculations and in vitro cytotoxicity assessment

Contact Info

Product

Resources

About

The effect of structural configuration on the DNA binding andin vitroantioxidant properties of new copper(ii) N₂O₂Schiff base complexes