Nigella sativa and its chemical constituents: A promising approach against neurodegenerative disorders

Chaturvedi, Swati; Gupta, Rohit; Gupta, Neha; Ansari, Nazim; Ghazi, Nessrin; Naseem, Asma; Chaudhry, Ranjay K.; Ansari, Uzair A.; Khan, Andleeb; Jahan, Sadaf

doi:10.1016/b978-0-12-824462-3.00013-5

Cited by 2 publications

(2 citation statements)

References 62 publications

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“…Due to its bioactive components, black seed oil has been shown in this study to improve electrolyte imbalance. This agrees with the reports of Laranjeiraet al 71 and Chaturvedi et al 72 This study further showed that NS extract can reduce kidney histological damage.…”

Section: Effects Of Nigella Sativa Oil On Serum Urea and Creatinine L...supporting

confidence: 93%

Black Seed Oil-induced Amelioration of Renal Dysfunction in a Rat Model of Diabetes Mellitus and Periodontitis

2023

TJNPR

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Periodontitis can exacerbate and promote the progression of chronic kidney disease through direct or indirect processes such as the impact of periodontal pathogens, antigens, endotoxins, and chronic inflammatory load produced by released cytokines. [11][12][13][14][15] When the pancreas fails to create enough insulin or when the body has difficulties utilizing the insulin that is produced, diabetes mellitus (DM), a chronic illness, can arise. Insulin is the hormone that regulates blood sugar. Hyperglycemia, a symptom of this metabolic and endocrine condition, results from either inadequate insulin synthesis by the pancreas (DM type 1) or incorrect insulin response by the pancreas (DM type 2), and it is defined by elevated blood glucose levels. 16,17 Diabetes mellitus (DM) is a condition that has serious side effects. It is a significant global cause of disease and mortality. According to statistics, 2.8% of people worldwide have diabetes, and by 2025, that number is expected to rise to more than 5.4%. 18 Oxidative stress, cardiac problems, renal failure, neuro-degeneration, and immunological dysfunction are all caused by oxidative stress, which is directly linked to the formation of free radicals in diabetes mellitus. 19 Strong evidence exists to back up the idea that diabetes and periodontitis are interdependent, with diabetes increasing the likelihood of developing periodontitis and periodontal inflammation negatively impacting glycemic control. 20,21 Diabetes individuals experience periodontitis three times more frequently than non-diabetics do. 22 Diabetes and periodontitis have both been linked to kidney damage. 15,23 A serious socioeconomic and healthcare issue, kidney dysfunction, particularly Chronic Kidney Disease (CKD), affects almost 7 billion people globally. In the world, 8724 out of every 100,000 individuals have kidney disease, an amount that is ten times greater than cancer patients and surpasses diabetes by 80%; it

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Section: Effects Of Nigella Sativa Oil On Serum Urea and Creatinine L...supporting

confidence: 93%

Black Seed Oil-induced Amelioration of Renal Dysfunction in a Rat Model of Diabetes Mellitus and Periodontitis

2023

TJNPR

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“…N. sativa has been considered as an herbal medicine in Islamic culture and in Avicenna's famous book, Qanun [ 20 ]. In this regard, it has been mentioned that the seeds of N. sativa act as traditional remedies for the treatment of different neurological-based diseases, such as memory impairment, epilepsy, pain, and neurotoxicities, as well as Alzheimer's (AD) and Parkinson's (PD) diseases [ 20 , 21 ]. Phytochemical analysis has reported the presence of different chemical compounds in N. sativa, such as phospholipids [ 22 ], fatty acids [ 23 ], vitamins [ 24 ], and ascorbic acid [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Nigella sativa Oil Reduces LPS-Induced Microglial Inflammation: An Evaluation on M1/M2 Balance

Hosseini

Rahimi

Rakhshandeh

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objectives. The immune system plays a critical defence role against infections, injuries, and carcinogenic stimuli. As the macrophages of the brain resides in the innate immune system, microglia and their polarisation (M1/M2) play regulatory roles in inflammation in CNS, such as Parkinson’s, Alzheimer’s, dementia complex, and multiple sclerosis. Nigella sativa belongs to the Ranunculaceae family and has different anti-inflammatory and antioxidant effects. We conducted this study to evaluate the anti-inflammatory and protective properties of N. sativa oil (NSO) on the microglial cells and their polarisation (M1/M2) in the presence of LPS as a model of neuroinflammation. Methods. The protective effects of NSO (10–40 µg/ml) were studied on the LPS-induced microglial cells, and the levels of tumour necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6, prostaglandin E2 (PGE2), and IL-10 were evaluated using both ELISA and gene expression methods. The levels of cyclooxygenase-2 (COX-2), inducible NOS (iNOS), and arginase-1 (Arg1) were also evaluated using the real-time PCR method. In addition, nitrite oxide (NO) and urea were measured using biochemical methods. Results. NSO decreased LPS-induced toxicity at all doses ( P < 0.001). NSO (10–40 μg/ml) also significantly reduced the levels of TNF-α, PGE2, IL-1β, and IL-6 in the presence of LPS ( P < 0.01 to 0.001). Pretreatment with NSO attenuated the levels of iNOS but increased Arg1 ( P < 0.001). The ratio of iNOS/Arg1 was also decreased in the presence of NSO ( P < 0.001) than that of the LPS group ( P < 0.001). Conclusion. NSO attenuated LPS-induced inflammation and increased microglia’s anti-inflammatory status. These results may prove that NSO is potentially an immunomodulator for various neurodegenerative diseases by M1 phenotype dominancy, such as Alzheimer’s and Parkinson’s diseases.

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Nigella sativa and its chemical constituents: A promising approach against neurodegenerative disorders

Cited by 2 publications

References 62 publications

Black Seed Oil-induced Amelioration of Renal Dysfunction in a Rat Model of Diabetes Mellitus and Periodontitis

Black Seed Oil-induced Amelioration of Renal Dysfunction in a Rat Model of Diabetes Mellitus and Periodontitis

Nigella sativa Oil Reduces LPS-Induced Microglial Inflammation: An Evaluation on M1/M2 Balance

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