NIR-II fluorescence microscopic imaging of cortical vasculature in non-human primates

Cai, Zhaochong; Zhu, Liang; Wang, Mengqi; Roe, Anna Wang; Wang, Xi; Qian, Jun

doi:10.7150/thno.43533

Cited by 92 publications

(62 citation statements)

References 55 publications

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“…2a). [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] However, the uorescence efficiency (F) decreases remarkably with wavelength (l), especially in low energy bandgap NIR-II materials, as intramolecular motions around the single or double bond result in dominant non-radiative relaxation dynamics (Fig. 2b).…”

Section: Introductionmentioning

confidence: 99%

Structural and process controls of AIEgens for NIR-II theranostics

et al. 2021

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Section: Introductionmentioning

confidence: 99%

Structural and process controls of AIEgens for NIR-II theranostics

et al. 2021

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“…Optical detection in the SWIR region of the electromagnetic spectrum offers increased contrast, resolution, and penetrative properties, compared to detection in the visible (VIS, 350–700 nm) and NIR regions. ICG has proven to be a successful SWIR contrast agent upon 785 or 808 nm excitation in single channel experiments for vasculature [23,24] and dental [25] imaging, and alongside dyes with more red‐shifted absorption properties in multichannel experiments [26,27] . Notably, the SWIR emission of ICG was recently exploited in multispectral image‐guided surgery in humans [28] …”

Section: Introductionmentioning

confidence: 99%

“…These properties also make ICG a natural benchmark for the development of improved and complementary optical tools for the SWIR region. Indeed, ICG is commonly employed as a comparison for emitters and imaging applications in both the NIR and the SWIR regions [24,29–38] . However, the reported photophysical properties of ICG vary greatly in the literature, resulting in variable and inconsistent comparisons.…”

Section: Introductionmentioning

confidence: 99%

Photophysical Properties of Indocyanine Green in the Shortwave Infrared Region

2021

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With the growing development of new contrast agents for optical imaging using near‐infrared and shortwave infrared (SWIR) wavelengths, it is essential to have consistent benchmarks for emitters in these regions. Indocyanine green (ICG), a ubiquitous and FDA‐approved organic dye and optical imaging agent, is commonly employed as a standard for photophysical properties and biological performance for imaging experiments at these wavelengths. Yet, its reported photophysical properties across organic and aqueous solvents vary greatly in the literature, which hinders its ability to be used as a consistent benchmark. Herein, we measure photophysical properties in organic and aqueous solvents using InGaAs detection (∼950–1,700 nm), providing particular relevance for SWIR imaging.

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“…As shown in Figure 1d, the Mn‐doped Ag 2 Se QDs emit strong fluorescence at 1030 nm. Using indocyanine green (ICG) as reference, [ 56 ] the maximum photoluminescence quantum yield (PLQY) of Mn‐doped Ag 2 Se QDs was 21%. Figure 1e shows the time‐resolved photoluminescence decay curves of Mn‐doped and undoped Ag 2 Se QDs with the same emission wavelength.…”

Section: Resultsmentioning

confidence: 99%

An Ultra‐Stable, Oxygen‐Supply Nanoprobe Emitting in Near‐Infrared‐II Window to Guide and Enhance Radiotherapy by Promoting Anti‐Tumor Immunity

Wang

Huang

et al. 2021

Adv Healthcare Materials

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Currently, radiotherapy (RT) is the main method for cancer treatment. However, the hypoxic environment of solid tumors is likely to cause resistance or failure of RT. Moreover, high‐dose radiation may cause side effects to surrounding normal tissues. In this study, a new type of nanozyme is developed by doping Mn (II) ions into Ag2Se quantum dots (QDs) emitting in the second near‐infrared window (NIR‐II, 1000–1700 nm). Through the catalysis of Mn (II) ions, the nanozymes can trigger the rapid decomposition of H2O2 and produce O2. Conjugated with tumor‐targeting arginine‐glycine‐aspartate (RGD) tripeptides and polyethylene glycol (PEG) molecules, the nanozymes are then constructed into in vivo nanoprobes for NIR‐II imaging‐guided RT of tumors. Owing to the radiosensitive activity of the element Ag, the nanoprobes can promote radiation energy deposition. The specific tumor‐targeting and NIR‐II emitting abilities of the nanoprobes facilitate the precise tumor localization, which enables precise RT with low side effects. Moreover, their ultra‐stability in the living body ensures that the nanoprobes continuously produce oxygen and relieve the hypoxia of tumors to enhance RT efficacy. Guided by real‐time and high‐clarity imaging, the nanoprobe‐mediated RT promotes anti‐tumor immunity, which significantly inhibits the growth of tumors or even cures them completely.

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NIR-II fluorescence microscopic imaging of cortical vasculature in non-human primates

Cited by 92 publications

References 55 publications

Structural and process controls of AIEgens for NIR-II theranostics

Structural and process controls of AIEgens for NIR-II theranostics

Photophysical Properties of Indocyanine Green in the Shortwave Infrared Region

An Ultra‐Stable, Oxygen‐Supply Nanoprobe Emitting in Near‐Infrared‐II Window to Guide and Enhance Radiotherapy by Promoting Anti‐Tumor Immunity

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