NIR light triggered size variable “remote-controlled cluster bomb” for deep penetration and tumor therapy

Cao, Weiwei; He, Yuchu; Zhu, Ruiyan; He, Yaqian; Hao, Zining; Zhao, Qianqian; He, Hong; Wang, Shuai; Li, Chunhui; Gao, Dawei

doi:10.1016/j.cej.2019.122080

Cited by 33 publications

(17 citation statements)

References 41 publications

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“…Due to low absorption of water and hemoglobin, the NIR region (700–1,300 nm) is ideal for gold nanomaterials to have a deeper penetration depth in the tumor therapy and imaging (Bao et al, 2016). Gold nanomaterial can convert the absorbed light energy into overheating in the surrounding environment through non-radiative conversion owing to the desirable absorption cross sections and photothermal conversion efficiencies (η) in NIR region (Cao et al, 2019). Therefore, gold nanomaterials are considered as exogenous photothermal transduction agents for PTI and contrast agents for PAI, which can accumulate at tumor tissue via the enhanced permeability and retention (EPR) effect (Henry et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Gold Nanomaterials for Imaging-Guided Near-Infrared in vivo Cancer Therapy

Tian

Sheng

Wang

2019

Front. Bioeng. Biotechnol.

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In recent years, tremendous efforts have been devoted into the fields of valuable diagnosis and anticancer treatment, such as real-time imaging, photothermal, and photodynamic therapy, and drug delivery. As promising nanocarriers, gold nanomaterials have attracted widespread attention during the last two decades for cancer diagnosis and therapy due to their prominent properties. With the development of nanoscience and nanotechnology, the fascinating bio-applications of functionalized gold nanomaterials have been gradually developed from in vitro to in vivo. This mini-review emphasizes some recent advances of photothermal imaging (PTI), surface-enhanced Raman scattering (SERS) imaging, and photoacoustic imaging (PAI)-guided based on gold nanomaterials in vivo therapy in near infrared region (>800 nm). We focus on the fundamental strategies, characteristics of bio-imaging modalities involving the advantages of multiples imaging modalities for cancer treatment, and then highlight a few examples of each techniques. Finally, we discuss the perspectives and challenges in gold nanomaterial-based cancer therapy.

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Section: Introductionmentioning

confidence: 99%

Gold Nanomaterials for Imaging-Guided Near-Infrared in vivo Cancer Therapy

Tian

Sheng

Wang

2019

Front. Bioeng. Biotechnol.

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“…Serum aspartate aminotransferase (AST) and ALT are generally used to analyze hepatotoxicity 0 , and BUN is an indicator of renal function. 11 , 12 The results showed that the serum biochemical indexes of the AgPTIL + NIR group were basically the same as those of the normal saline group after 14 days, further confirming the good biological safety of AgPTIL.…”

Section: Resultsmentioning

confidence: 63%

Highly Active Nano-Reactor for Responding Tumor Microenvironment and Antitumor Therapy

Zhang

Liu

2022

Technol Cancer Res Treat

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The tumor microenvironment is complex and changeable, so the design of a nano-delivery system for the tumor microenvironment has attracted wide attention. Based on this, we designed an intelligent nano-reactor for the characteristics of acidic pH and hypoxia in the tumor microenvironment. Firstly, the silver nano-balls were synthesized by the biological template method, which exhibited a good photothermal conversion efficiency and can realize the photothermal treatment of tumor sites. Subsequently, the hypoxic prodrug tirapazamine (TPZ) and polydopamine (PDA) for chemotherapy were self-assembled. After PDA arrived at the tumor site (pH 5.5) from the normal physiological environment (pH 7.4), the hypoxic prodrug TPZ was released in pH response by PDA. Subsequently, TPZ selectively induced obvious cell damage under tumor hypoxia stimulation but had no toxic effect on normal cells under normal oxygen. In addition, the nano-converter was loaded with iRGD on the surface, which enhanced the targeted delivery of the nano-reactor to achieve a highly effective antitumor effect. The nano-reactor was capable of combining photothermal/chemotherapy therapy. Importantly, it can selectively kill tumor cells without damaging normal cells based on the characteristics of the tumor microenvironment, with high bio-safety and clinical transformation potential.

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“…Although nanomedicines have brought great hope to tumor treatments in recent years, the ine cient penetration into tumor severely limits their application. Previous studies focused on size-shrinking of drugs [43][44][45] , remodeling of tumor microenvironment 46 , and transcytosis [47][48][49] to enhance the tumor penetration. However, none of these strategies overcome the key hinder of drug delivery: TIP, especially TIFP.…”

Section: Discussionmentioning

confidence: 99%

Pyroelectric Catalysis-Based “Nano-Lymphatic” Reduces Tumor Interstitial Pressure for Enhanced Penetration and Hydrodynamic Therapy

Cong

et al. 2021

ACS Nano

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Owing to de ciency of lymphatic re ux in the tumor, the retention of tumor interstitial uid causes the aggravation of tumor interstitial pressure (TIP), which leads to unsatisfactory tumor penetration of nanomedicine. It is the main inducement of tumor recurrence and metastasis. Herein, we design a pyroelectric catalysis-based "Nano-lymphatic" to decrease the TIP for enhanced tumor penetration and treatments. It realizes photothermal therapy and decomposition of tumor interstitial uid under NIR-II laser irradiation after reaching the tumor, which reduces the TIP for enhanced tumor penetration.Simultaneously, reactive oxygen species generated during the pyroelectric catalysis can further damage deep tumor stem cells. The results indicate that the "Nano-lymphatic" relieves 52% of TIP, leading to enhanced tumor penetration, which effectively inhibits the tumor proliferation (93.75%) and recurrence.Our nding presents a novel strategy to reduce TIP by pyroelectric catalysis for enhanced tumor penetration and improved treatments, which is of great signi cance for drug delivery.

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NIR light triggered size variable “remote-controlled cluster bomb” for deep penetration and tumor therapy

Cited by 33 publications

References 41 publications

Gold Nanomaterials for Imaging-Guided Near-Infrared in vivo Cancer Therapy

Gold Nanomaterials for Imaging-Guided Near-Infrared in vivo Cancer Therapy

Highly Active Nano-Reactor for Responding Tumor Microenvironment and Antitumor Therapy

Pyroelectric Catalysis-Based “Nano-Lymphatic” Reduces Tumor Interstitial Pressure for Enhanced Penetration and Hydrodynamic Therapy

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