NIR‐Mediated Nanohybrids of Upconversion Nanophosphors and Fluorescent Conjugated Polymers for High‐Efficiency Antibacterial Performance Based on Fluorescence Resonance Energy Transfer

Li, Junting; Zhao, Qi; Shi, Feng; Liu, Chenghui; Tang, Yanli

doi:10.1002/adhm.201600868

Cited by 48 publications

(31 citation statements)

References 36 publications

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“…Besides, the CPs-PDT system can be excited by the NIR laser, which can bypass the penetration issues and was explored for cancer therapy in the deeper tissues. [164,165] Benefited from the excellent light-harvesting of CPs, the energy transferred from CPs to PSs (e.g., porphyrin) can dramatically enhance the ROS production efficiency. Based on the energy transfer mechanism, Wu et al recently reported an energy-transfer amplified Pdots which can generate singlet oxygen for in vivo PDT.…”

Section: Photodynamic Therapymentioning

confidence: 99%

Conjugated Polymers: Optical Toolbox for Bioimaging and Cancer Therapy

Wei

Liu

et al. 2021

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Conjugated polymers (CPs) are capable of coordinating the electron coupling phenomenon to bestow powerful optoelectronic features. The light‐harvesting and light‐amplifying properties of CPs are extensively used in figuring out the biomedical issues with special emphasis on accurate diagnosis, effective treatment, and precise theranostics. This review summarizes the recent progress of CP materials in bioimaging, cancer therapeutics, and introduces the design strategies by rationally tuning the optical properties. The recent advances of CPs in bioimaging applications are first summarized and the challenges to clear the future directions of CPs in the respective area are discussed. In the following sections, the focus is on the burgeoning applications of CPs in phototherapy of the tumor, and illustrates the underlying photo‐transforming mechanism for further molecular designing. Besides, the recent progress in the CPs‐assistant drug therapy, mainly including drug delivery, gene therapeutic, the optical‐activated reversion of tumor resistance, and synergistic therapy has also been discussed elaborately. In the end, the potential challenges and future developments of CPs on cancer diagnosis and therapy are also illuminated for the improvement of optical functionalization and the promotion of clinical translation.

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Section: Photodynamic Therapymentioning

confidence: 99%

Conjugated Polymers: Optical Toolbox for Bioimaging and Cancer Therapy

Wei

Liu

et al. 2021

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“…In 2016, Tang's group designed and synthesized a hybrid nanomaterial. 53 This new material combines a water-soluble conjugated polymer and an up-conversion nanomaterial. Under the illumination of the NIR light source, which can penetrate deep tissue, photodynamic therapy (PDT) of this hybrid nanomaterial is achieved to generate reactive oxygen species to effectively kill bacteria (Figure 9).…”

Section: Application Of Cpns In Pathogen Detectionmentioning

confidence: 99%

“…Photodynamic antibacterial therapy has been widely investigated in recent years, but the light source used restricts its application in deep infections. In 2016, Tang’s group designed and synthesized a hybrid nanomaterial . This new material combines a water-soluble conjugated polymer and an up-conversion nanomaterial.…”

Section: Application Of Cpns In Pathogen Detection and Killingmentioning

confidence: 99%

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Design and Application of Conjugated Polymer Nanomaterials for Detection and Inactivation of Pathogenic Microbes

Lü

Jia

et al. 2020

ACS Appl. Bio Mater.

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Infectious deaths due to drug resistance of pathogens caused by the abuse of antibiotics have seriously endangered public health in the world. Therefore, it is urgent to develop diversified methods for rapid detection of pathogens and antimicrobial drugs that are not prone to develop resistance. Conjugated polymers (CPs) are macromolecular compounds composed of many luminescent units through covalent bond. They have high molar extinction coefficient and strong light absorption capacity. In addition, they have good photo stability and excellent biocompatibility. In recent years, conjugated polymer nanomaterials (CPNs) have stimulated the research enthusiasm of many researchers because of the materials' small size, high fluorescence intensity, and easy modification. This article reviews the recent research progress of conjugated polymer nanomaterials in the detection and killing of pathogenic microbes.

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“…The traditional methods of drug therapies lead to the evolution of several drug‐resistant bacteria such as Salmonella , E. Coli , and Staphylococcus , which poses more risks to human health. To overcome this problem, the exploration of new therapeutic modalities to fight against bacterial infections or to enhance the antibacterial activity of present therapies toward drug‐resistant bacteria is of paramount importance . UCNP‐photosensitizer‐based PDT triggered by NIR light is an ideal therapeutic method for this purpose.…”

Section: Biological Applications Of Ucnpsmentioning

confidence: 99%

Recent Advancements in Ln‐Ion‐Based Upconverting Nanomaterials and Their Biological Applications

Chhetri

Karmakar²,

Ghosh

2019

Part & Part Syst Charact

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Upconversion nanoparticles (UCNPs) convert low‐energy infrared (IR) or near‐infrared (NIR) photons into high‐energy emission radiation ranging from ultraviolet to visible through a photon upconversion process. In comparison to conventional fluorophores, such as organic dyes or semiconductor quantum dots, lanthanide‐ion‐doped UCNPs exhibit high photostability, no photoblinking, no photobleaching, low cytotoxicity, sharp emission lines, and long luminescent lifetimes. Additionally, the use of IR or NIR for excitation in such UCNPs reduces the autofluorescence background and enables deeper penetration into biological samples due to reduced light scattering with negligible damage to the samples. Because of these attributes, UCNPs have found numerous potential applications in biological and medicinal fields as novel fluorescent materials. Different upconversion mechanisms commonly observed in UCNPs, various methods that are used in their synthesis, and surface modification processes are discussed. Recent applications of Ln‐UCNPs in the biological and medicinal fields, including in vivo and in vitro biological imaging, multimodal imaging, photodynamic therapy, drug delivery, and antibacterial activity, are also presented.

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NIR‐Mediated Nanohybrids of Upconversion Nanophosphors and Fluorescent Conjugated Polymers for High‐Efficiency Antibacterial Performance Based on Fluorescence Resonance Energy Transfer

Cited by 48 publications

References 36 publications

Conjugated Polymers: Optical Toolbox for Bioimaging and Cancer Therapy

Conjugated Polymers: Optical Toolbox for Bioimaging and Cancer Therapy

Design and Application of Conjugated Polymer Nanomaterials for Detection and Inactivation of Pathogenic Microbes

Recent Advancements in Ln‐Ion‐Based Upconverting Nanomaterials and Their Biological Applications

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