Nitric oxide and atherosclerosis: An update

Napoli, Claudio; Nigris, Filomena de; Williams-Ignarro, Sharon; Pignalosa, Orlando; Sica, Vincenzo; Ignarro, Louis J.

doi:10.1016/j.niox.2006.03.011

Cited by 410 publications

(298 citation statements)

References 143 publications

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“…The effect observed was susceptibility when a recessive model of inheritance was assumed (TT X GT+GG). The biological plausibility of the data described here could be supported by epidemiological and experimental evidence that suggest an association among lipid, blood pressure (29), glucose levels and modulation of NO levels (5,9,19). However, this association was sex-dependent, since it was evident in males, whereas females showed the TT genotype association only with hypertension.…”

Section: Discussionsupporting

confidence: 69%

“…This molecule has a protective role by suppressing the abnormal proliferation of vascular smooth muscle cells (VSMCs) following various pathological situations including atherosclerosis (5,6). Additionally, NO facilitates the uptake and metabolism of glucose in skeletal muscle (7,8) In contrast, the oxidative effects of NO, which may occur through functional variation in NO synthase genes, may play a role in insulin resistance and type II diabetes (9).…”

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confidence: 99%

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Association between 894G>T endothelial nitric oxide synthase gene polymorphisms and metabolic syndrome

Piccoli

Gottlieb

Castro

et al. 2008

Arq Bras Endocrinol Metab

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Metabolic syndrome (MS) is a cluster of cardiovascular risk factors such as hypertension, dyslipidemia, obesity and type II diabetes. Here, we performed a case-control study analyzing the association between 894G>T endothelial nitric oxide synthase gene polymorphism (NOS3) and MS in 616 subjects. Genotype frequencies were TT= 9.3%, GG= 37.2 and TG= 53.6% and the allelic frequencies were T=0.36 and G= 0.64. We observed a higher TT genotype frequency in the male MS group than control subjects (p=0.02), independent of other variables. We found an association between hypertension and TT genotype in females. Our data suggests that 894G>T plays a signifi cant role in the mechanistic interaction between metabolic risk such as hypertension and MS, although sex-related differences may exist. A síndrome metabólica (SM) é um agrupamento de fatores de riscos cardiovasculares, tais como hipertensão, dislipidemia, obesidade e diabetes tipo 2. Realizou-se um estudo caso-controle para analisar a associação entre o polimorfi smo (894G>T do gene da enzima endotelial oxido nítrico sintetase (NOS3) e a SM em 616 voluntários. As freqüências genotípicas foram: TT = 9,3%, GG = 37,2% e TG = 53,6%, e as freqüências alélicas T = 0,36 e G = 0,64. Observou-se freqüência mais alta do genótipo TT em homens com SM do que nos controles, independentemente de outros fatores (p = 0,02). Também observou-se associação entre hipertensão e o genótipo TT nas mulheres. Os dados do estudo sugerem que o polimorfi smo 894G>T pode ter papel significativo na interação entre riscos metabólicos, tais como a hipertensão e a SM, ainda que existam diferenças relacionadas ao sexo.

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Section: Discussionsupporting

confidence: 69%

mentioning

confidence: 99%

Association between 894G>T endothelial nitric oxide synthase gene polymorphisms and metabolic syndrome

Piccoli

Gottlieb

Castro

et al. 2008

Arq Bras Endocrinol Metab

View full text Add to dashboard Cite

show abstract

“…NO failure, synthesis and signalling are related to atherogenesis and risk of death. NO plays a crucial vascular role in endothelial relaxation and vasodilatation, and with lower CVD risk, as previously reported [32]. There is a strong link between NO production and vascular/endothelial integrity and functionality.…”

Section: Discussionsupporting

confidence: 73%

A tennis-based health program for middle-aged men who are at risk for heart disease

Rosa¹,

Fuentes-García²,

Remor³

et al. 2017

Integr Obesity Diabetes

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The purpose of this study was to investigate the health effects of an adapted tennis-based exercise program, in middle-aged men with moderate risk of cardiovascular diseases (CVD). Fifteen men (44.9 ± 4.9 years) with two or more CVD risk factors, completed an eight-week health program that included a continuous tennisbased exercise protocol with constant and controlled intensity between 70%-85% of maximum heart rate and a standard nutritional orientation. Participants were assessed at the beginning and end of the exercise program for standard parameters related to CVD and the Framingham risk score, motor skills and cardiopulmonary fitness, peripheral inflammation (neopterin levels), oxidative stress (nitric oxide and carbonylated protein content), and mitochondrial function (lymphocyte complex I activity). Exercise improved muscle strength and power, speed, agility and flexibility, V O 2 max and metabolic equivalents. The participants experienced decreases in body mass index, waist circumference, total and LDL-cholesterol, and reduction in the Framingham Risk Score. Exercise also decreased peripheral oxidative stress and production of nitric oxide. In addition, the increased V O 2 at ventilatory threshold 1 correlated with enhanced mitochondrial activity in blood lymphocytes. The tennis-based exercise program adapted to sustaining moderate and constant intensity represents a valuable non-pharmacological intervention to prevent CVD.speed, muscle power and endurance, among others. Outdoor sports are motivating and enjoyable with high adherence levels [6].

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“…Furthermore, previous study demonstrated that several chemokines accelerated atherosclerosis (31), while the inhibition of chemokines reduced the atherosclerosis (32). In addition, activation or inhibition NO differentially regulates atherosclerosis (33).…”

Section: Discussionmentioning

confidence: 91%

Correlations of high-sensitivity C-reactive protein and atherosclerosis in Japanese type 2 diabetic patients

et al. 2007

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Background: The elevated level of high-sensitivity C-reactive protein (HSCRP) and aortic stiffness are associated with high mortality in type 2 diabetic patients. We tested the hypothesis that the HSCRP correlates with aortic stiffness and insulin resistance in type 2 diabetic patients. Material and methods: The study consisted of 46 Japanese patients with type 2 diabetes and high HSCRP group (0.3-1.0 mg/dl, age: 57G5 years, meanGS.D.) and a control group of 55 age-matched patients with low HSCRP group (!0.3 mg/dl, 57G6 years). Brachial-ankle pulse wave velocity (BaPWV) was measured by automatic oscillometric method and was used as an index of atherosclerosis. Results: The body mass index (BMI) values (P!0.05) and waist circumferences (P!0.0005) and the waist-to-hip ratios (P!0.05) were higher in the high HSCRP group than in the low HSCRP group. The BaPWV was higher in the high HSCRP group than in the low HSCRP group (P!0.0001). Fasting plasma glucose (FPG; P!0.005) and insulin concentrations (P!0.0001), and the homeostasis model assessment (HOMA) index (P!0.0001), were higher in the high HSCRP group than in the low HSCRP group. Multiple regression analysis showed that HSCRP levels were independently predicted by BaPWV and HOMA index. Conclusions: Our results indicate that the elevated level of HSCRP in Japanese patients with type 2 diabetes is characterized by increased aortic stiffness and insulin resistance, and that the BaPWV and HOMA index are independent predictors of HSCRP.

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Nitric oxide and atherosclerosis: An update

Cited by 410 publications

References 143 publications

Association between 894G>T endothelial nitric oxide synthase gene polymorphisms and metabolic syndrome

Association between 894G>T endothelial nitric oxide synthase gene polymorphisms and metabolic syndrome

A tennis-based health program for middle-aged men who are at risk for heart disease

Correlations of high-sensitivity C-reactive protein and atherosclerosis in Japanese type 2 diabetic patients

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