Nitric Oxide, Its Metabolites, and Glutathione System in Children With Chronic Viral Hepatitis В and С

Коркоташвили, Л В; Romanova, Svetlana; Колесов, С. Н.

doi:10.15690/vramn.v68i10.784

Annals RAMS

2013

DOI: 10.15690/vramn.v68i10.784

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Nitric Oxide, Its Metabolites, and Glutathione System in Children With Chronic Viral Hepatitis В and С

Л В Коркоташвили

Svetlana Romanova

С. Н. Колесов

Abstract: Aim. To detect changes in the concentration of nitric oxide and its metabolites -nitrites and nitrates in conjunction with the indices of the glutathione system in the children with chronic hepatitis В and С. Patients and methods. In the research took a part 76 patients (boys or girls (Вестник РАМН. 2013; 10: 26-30)

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2021

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Cited by 2 publications

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The significance of the detoxification system disorders in fibrogenesis in Chronic Viral Hepatitis С in children

Galova¹,

Краснов²

2021

Det. infekc.

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Aim: to determine the relationship between of levels»protoxic» metabolites and «profibrotic» metabolites in the blood serum in children with chronic viral hepatitis C (HCV).Material and methods: the authors examined 54 children 14.0[6,0] years old with HCV. The blood serum levels of Molecules of average mass, Oligopeptides, Alcohol dehydrogenase, Glutathione-S-transferase, Ammonia, Arginase and Collagen IV have been studied.Results: A high level of «protoxic» metabolites in the blood serum was associated with a disorder of their elimination. The relationship with viral replication and biochemical hepatitis activity has not been identified. The collagen IV blood serum level was correlated with the accumulation and elimination of «protoxic» metabolites: R = 0.63, F = 5.19, p = 0.018.Conclusion: The level of collagen IV in the children's blood serum was associated with the accumulation and the elimination of «protoxic» metabolites.

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The significance of the detoxification system disorders in fibrogenesis in Chronic Viral Hepatitis С in children

Galova¹,

Краснов²

2021

Det. infekc.

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The state of the antioxidant defense of the body of ice hockey players during the sports season

Rakhmanov

Bogomolova

Razgulin

et al. 2021

Sanitarnyj Vrač (Sanitary Doctor)

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Excessive formation of free radicals and active forms of nitrogen damages enzymes, proteins, membrane phospholipids, nucleic acids. The indicators of the antioxidant defense of the body of professional ice hockey players were evaluated under oxidative and nitrosive stresses of various degrees during the game season. In blood samples of hockey players (n = 39), taken after 2.5 months, 4 and 6 months. games were determined by glutathione (total, reduced, oxidized), nitric oxide. Oxidative stress was ranked according to the levels of peroxides, the state of the antioxidant system — according to decomposed exogenous peroxide. Cortisol and testosterone were evaluated. Total glutathione exceeded the reference standards. Reduced and oxidized glutathione (below 10 units) indicated a decrease in antioxidant protection within 4 months. Nitric oxide increased to 71.6–103.2 μM / L; nitrosive stress was detected in 38.5 %. Testosterone was within normal limits, cortisol was higher in 80.0–95.8 %. Average oxidative stress was detected in 20.7 %, high — in 4.0 %; the antioxidant capacity of the whey is medium to high. Total and reduced glutathione, peroxides, and decomposed peroxide confirmed the significant compensatory reserves of the body. The metabolism was dominated by catabolic processes. The periods of maximum growth of the level of cortisol (2.5–4 months of games) corresponded to the minimum levels of the body’s antioxidant defense; individuals with signs of nitrosive stress were registered. This has proven to be a health risk of exercise in athletes. The condition for the prevention of dysadaptation shifts is the optimal level of stress at the stages of the playing season, as well as ensuring the high-quality composition of the diet. English version of the article is available at URL: https://panor.ru/articles/state-of-antioxidant-protection-of-ice-hockey-players-during-the-sports-season/72915.html

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Nitric Oxide, Its Metabolites, and Glutathione System in Children With Chronic Viral Hepatitis В and С

Cited by 2 publications

References 5 publications

The significance of the detoxification system disorders in fibrogenesis in Chronic Viral Hepatitis С in children

The significance of the detoxification system disorders in fibrogenesis in Chronic Viral Hepatitis С in children

The state of the antioxidant defense of the body of ice hockey players during the sports season

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