Nitric oxide production is not altered in preeclampsia

Abstract

Our study has demonstrated that there was no alteration in nitric oxide production in preeclampsia, thus contributing to the existing unresolved role of nitric oxide in the pathogenesis of preeclampsia. Further research is called for.

Maternal Endothelin-1 and Cyclic Guanosine Monophosphate Concentrations in Pregnancies Complicated by Pregravid and Gestational Diabetes Mellitus

“…Some earlier studies reported an increase of maternal NO in diabetes or preeclampsia [14,15] , whereas in one study [26] no alternation of NO production in preeclampsia was found. However, it seems that production of NO (or cGMP) and other vasodilators represents a compensatory and protective mechanism for variation of vasoconstrictors (including ET-1) production to maintain blood flow and limit platelet aggregation in the fetomaternal circulation [15] .…”

Analysis of nitrite and nitrate in biological samples using high-performance liquid chromatography

“…HPLC analyses of plasma/serum nitrite and nitrate have been employed to ascertain a role for NO in the pathogenesis of endothelial dysfunction in pregnant women with preeclampsia [63]. The HPLC-DAN method has been used to determine changes in placental NO synthesis during various stages of ovine fetal development (0.29 to 1.66 nmol/h per g placentomal tissue between Days 30 and 140 of gestation) [64].…”

Effect of intravenous hydralazine infusion on maternal plasma nitric oxide levels in gestations complicated with severe preeclampsia: a pilot study

“…Altered normal hemodynamic response and endothelial dysfunction are major pathophysiological manifestations of this entity [3,4]. Reports related to nitric oxide (NO) secretion and preeclampsia are contradictory, some studies indicating altered production and/or activity [5][6][7][8][9][10][11], others not [12][13][14]. These contradictions are most likely due to differences in the research approach, the analyzed NO metabolites and/or the applied measuring methods.…”