For removal of phosphorus (P) from swine liquid manure before land application, we developed a treatment process that produces low P effl uents and a valuable P by-product with minimal chemical addition and ammonia losses. Th e new wastewater process included two sequential steps: (i) biological nitrifi cation and (ii) increasing the pH of the nitrifi ed wastewater to precipitate P. We hypothesized that by reduction of inorganic buff ers (NH 4 + and carbonate alkalinity) via nitrifi cation, P could be selectively removed by subsequent hydrated lime [Ca(OH) 2 ] addition. Th e objective of the study was to assess if this new treatment could consistently reduce inorganic buff er capacity with varied initial concentrations of N (100-723 mg NH 4 + L −1 ), P (26-85 mg TP L −1 ), and alkalinity (953-3063 mg CaCO 3 L −1 ), and then effi ciently remove P from swine lagoon liquid. Th e process was tested with surface lagoon liquids from 10 typical swine farms in North Carolina. Each lagoon liquid received treatment in a nitrifi cation bioreactor, followed by chemical treatment with Ca(OH) 2 at Ca rates of 0, 2, 4, 6, 8, 10, and 12 mmol L −1 to precipitate P. Th is confi guration was compared with a control that received the same Ca rates but without the nitrifi cation pretreatment. Th e new process signifi cantly reduced >90% the inorganic buff ers concentrations compared with the control and prevented ammonia losses. Subsequent lime addition resulted in effi cient pH increase to ≥9.5 for optimum P precipitation in the nitrifi ed liquid and signifi cant reduction of effl uent total P concentration versus the control. With this new process, the total P concentration in treated liquid effl uent can be adjusted for on-farm use with up to >90% of P removal. Th e recovered solid Ca phosphate material can be easily exported from the farm and reused as P fertilizer. Th erefore, the new process can be used to reduce the P content in livestock effl uents to levels that would diminish problems of excess P accumulation in waste-amended soils.