NK cell recognition of hematopoietic cells by SLAM-SAP families

Chen, Shasha; Dong, Zhongjun

doi:10.1038/s41423-019-0222-4

Cited by 17 publications

(15 citation statements)

References 102 publications

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“… 285 , 286 The SLAM family consists of a number of transmembrane costimulatory receptors, such as CD150/SLAM, CD244/2B4, CD84, CD229/Ly-9, CD319/CRACC, and NTB-A. 287 Thus, SAP can bind via its SH2 domain to the ITSMs of various SLAM families of receptors, and this interaction plays a crucial role in mediating the costimulatory signals necessary for T cell activation. 283 Moreover, SAP also exerts its adaptor role by binding to various SH3 domain-containing proteins, such as FYN, PKCθ, βPix, and NCK1, 288 – 291 thus recruiting them to the SLAM family of transmembrane receptors.…”

Section: Positive Regulators Of T Cell Signalingmentioning

confidence: 99%

T cell receptor (TCR) signaling in health and disease

Shah

Al-Haidari

Sun

et al. 2021

Sig Transduct Target Ther

246

175

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Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in changes at the molecular and cellular levels in T cells. The outside environmental cues are translated into various signal transduction pathways within the cell, which mediate the activation of various genes with the help of specific transcription factors. These signaling networks propagate with the help of various effector enzymes, such as kinases, phosphatases, and phospholipases. Integration of these disparate signal transduction pathways is done with the help of adaptor proteins that are non-enzymatic in function and that serve as a scaffold for various protein–protein interactions. This process aids in connecting the proximal to distal signaling pathways, thereby contributing to the full activation of T cells. This review provides a comprehensive snapshot of the various molecules involved in regulating T cell receptor signaling, covering both enzymes and adaptors, and will discuss their role in human disease.

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Section: Positive Regulators Of T Cell Signalingmentioning

confidence: 99%

T cell receptor (TCR) signaling in health and disease

Shah

Al-Haidari

Sun

et al. 2021

Sig Transduct Target Ther

246

175

View full text Add to dashboard Cite

show abstract

“…NK cells are cytotoxic lymphocytes that are critical for the defense against infections and tumors (8). NK cell activation is governed by the integration of activating and inhibitory signals from cell surface receptors (9,10); NK cells detect cells that are under stress as a result of infection or malignancy and rapidly respond by secreting cytotoxic granules or death receptor ligands.…”

Section: Introductionmentioning

confidence: 99%

NK Cells in Autoimmune Diseases: Protective or Pathogenic?

2021

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Autoimmune diseases generally result from the loss of self-tolerance (i.e., failure of the immune system to distinguish self from non-self), and are characterized by autoantibody production and hyperactivation of T cells, which leads to damage of specific or multiple organs. Thus, autoimmune diseases can be classified as organ-specific or systemic. Genetic and environmental factors contribute to the development of autoimmunity. Recent studies have demonstrated the contribution of innate immunity to the onset of autoimmune diseases. Natural killer (NK) cells, which are key components of the innate immune system, have been implicated in the development of multiple autoimmune diseases such as systemic lupus erythematosus, type I diabetes mellitus, and autoimmune liver disease. However, NK cells have both protective and pathogenic roles in autoimmunity depending on the NK cell subset, microenvironment, and disease type or stage. In this work, we review the current knowledge of the varied roles of NK cell subsets in systemic and organic-specific autoimmune diseases and their clinical potential as therapeutic targets.

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“…T-bet binds to the promoter region of the IFN-γ gene and stimulates the protein expression of IFN-γ. CD150 combined with SLAM can bind to the signal molecule SAP and modulate the function of SLAM in IFN-γ production in hematopoietic cells [47,48]. The freeze-dried water extract of Radix Angelicae Sinensis could significantly decreased the expression of T-bet after 12 h of treatment.…”

Section: Discussionmentioning

confidence: 99%

The combination of Radix Astragali and Radix Angelicae Sinensis attenuates the IFN-γ-induced immune destruction of hematopoiesis in bone marrow cells

Liu

Wei

Wang

et al. 2019

BMC Complement Altern Med

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Background: Radix Astragali and Radix Angelicae Sinensis are two herbs that compose Danggui Buxue Tang (an herbal formula for treatment of anemia diseases). In this study, we explored the molecular mechanism and effective targets to immune destruction of bone marrow (BM) cells treated with Radix Astragali, Radix Angelicae Sinensis or a combination of two agents. The potential synergic advantages of two herbs should also be explored. Methods: The constituents of Radix Astragali and Radix Angelicae Sinensis were analyzed by high performance liquid chromatography-electrospray ionization/mass spectrometer system BM cells were separated from limbs of BALB/c mice, and immune destruction was induced with IFN-γ. The percentages of hematopoietic stem cells (HSCs) and CD3 + T cells were detected by flow cytometry. The distribution of T-bet and changes in the combination of SAP and SLAM in BM cells were observed by immunofluorescence. Western blotting was used to assay the expression of key molecules of the eIF2 signaling pathway in BM cells. Results: Seven constituents of Radix Astragali and six constituents of Radix Angelicae Sinensis were identified. The percentages of HSCs increased significantly after treatment with Radix Angelicae Sinensis, especially at high concentrations. The percentages of CD3 + T cells were significantly decreased after Radix Astragali and Radix Angelicae Sinensis treatment. However, the synergistic function of two-herb combinations was superior to that of the individual herbs alone. The distribution of T-bet in BM cells was decreased significantly after Radix Angelicae Sinensis treatment. The number of SLAM/SAP double-stained cells was increased significantly after Radix Astragali treatment at low concentrations. The phosphorylation levels of eIF2α were also reduced after Radix Astragali and Radix Angelicae Sinensis treatment. Conclusions: Radix Astragali and Radix Angelicae Sinensis could intervene in the immunologic balance of T lymphocytes, inhibit the apoptosis of BM cells induced by immune attack, restore the balance of the T cell immune response network and recover the hematopoietic function of HSCs. The synergistic effects of Radix Astragali and Radix Angelicae Sinensis were superior to those of each herb alone.

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NK cell recognition of hematopoietic cells by SLAM-SAP families

Cited by 17 publications

References 102 publications

T cell receptor (TCR) signaling in health and disease

T cell receptor (TCR) signaling in health and disease

NK Cells in Autoimmune Diseases: Protective or Pathogenic?

The combination of Radix Astragali and Radix Angelicae Sinensis attenuates the IFN-γ-induced immune destruction of hematopoiesis in bone marrow cells

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