NO-1886 (ibrolipim), a lipoprotein lipase activator, increases the expression of uncoupling protein 3 in skeletal muscle and suppresses fat accumulation in high-fat diet–induced obesity in rats

Kusunoki, Masataka; Tsutsumi, Kazuhiko; Iwata, Koshi; Yin, Wang; Nakamura, Toshio; Ogawa, Hitoshi; Nomura, Tomoko; Mizutani, Koya; A, Futenma; Utsumi, Keiko; Miyata, Tetsuro

doi:10.1016/j.metabol.2005.06.005

Cited by 19 publications

(19 citation statements)

References 23 publications

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“…LPL catalyzes the hydrolysis of TG contained in very-low-density lipoproteins and chylomicrons, leading to the release of free fatty acids and their subsequent uptake by myocytes for energy production or by adipocytes for reesterification and storage [45]. Also, LPL activators have been shown to have antiobesity properties [46]. In our study, a significant decrease in the expression levels of muscle LPL was observed in high-fat-diet-fed rats.…”

Section: Discussionsupporting

confidence: 55%

Down-regulation in muscle and liver lipogenic genes: EPA ethyl ester treatment in lean and overweight (high-fat-fed) rats

Pérez-Echarri

Pérez-Matute

Marcos-Gómez

et al. 2009

The Journal of Nutritional Biochemistry

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Section: Discussionsupporting

confidence: 55%

Down-regulation in muscle and liver lipogenic genes: EPA ethyl ester treatment in lean and overweight (high-fat-fed) rats

Pérez-Echarri

Pérez-Matute

Marcos-Gómez

et al. 2009

The Journal of Nutritional Biochemistry

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“…Up-regulation of UCP expression depends on the strain and tissue type. A high fat diet increased UCP3 mRNA expression in the skeletal muscle of C57BL/6J mice [15] and rats [24] but increased UCP2 expression only slightly in white adipose tissue of AKR mice and not at all in C57BL/6J mice [15] or in rats [24].…”

Section: Discussionmentioning

confidence: 88%

A mixture of the aqueous extract of Garcinia cambogia, soy peptide and l-carnitine reduces the accumulation of visceral fat mass in rats rendered obese by a high fat diet

Kim

Kim³

et al. 2007

Genes Nutr

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The aim of the present study was to investigate the anti-obesity effect of a mixture composed of Garcinia cambogia extract, soypeptide, and L: -carnitine (1.2:0.3:0.02, w/w/w) in rats rendered obese by a high-fat diet (HFD). Sprague-Dawley rats were fed either the high-fat control diet (CD) or the 0.38% mixture-supplemented HFD (CD + M) for 9 weeks. The mixture significantly reduced body weight gain and the accumulation of visceral fat mass in a rat model of HFD-induced obesity. Moreover, the mixture effectively lowered blood and hepatic lipid concentrations and serum glucose, insulin, c-peptide, and leptin levels in rats with HFD-induced obesity. Results from real-time reverse transcription-polymerase chain reaction analyses indicated that the expression levels of leptin, tumor necrosis factor-alpha (TNF-alpha), and sterol regulatory element binding protein 1c (SREBP1c) genes in the epididymal fat tissue of rats fed the CD + M diet were 0.4-, 0.6-, and 0.48-fold, respectively, of those found in the CD rats (P < 0.05), while expression of the uncoupling protein 2 (UCP2) gene in epididymal adipose tissue was 1.25-fold (P < 0.05) of that found in CD rats. In conclusion, a mixture composed of G. cambogia extract, soy peptide, and L: -carnitine attenuated visceral fat accumulation and improved dyslipidemia in a rat model with HFD-induced obesity.

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“…In another study of adipose LPL and obesity, leptin‐deficient (ob/ob) mice lacking adipose LPL but expressing skeletal muscle LPL demonstrated reduced weight and fat mass compared to ob/ob mice which did not lack LPL, although the apparent resistance to obesity conferred by adipose LPL knockout was not observed in non‐ob/ob mice (29). Animal studies demonstrating that the LPL activator NO‐1886 (ibrolipim) is associated with decreased fat accumulation and increased uncoupling protein 3 mRNA in high fat–induced obese animals suggest a role for LPL in energy balance, possibly through stimulation of increased fatty acid oxidation by skeletal muscle (30).…”

Section: Discussionmentioning

confidence: 99%

Apolipoprotein A5 and Lipoprotein Lipase Interact to Modulate Anthropometric Measures in Hispanics of Caribbean Origin

Smith

Tucker

Lai

et al. 2010

Obesity

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Apolipoprotein A5 (APOA5) and lipoprotein lipase (LPL) proteins interact functionally to regulate lipid metabolism, and single‐nucleotide polymorphisms (SNPs) for each gene have also been associated independently with obesity risk. Evaluating gene combinations may be more effective than single SNP analyses in identifying genetic risk, but insufficient minor allele frequency (MAF) often limits evaluations of potential epistatic relationships. Populations with multiple ancestral admixtures may provide unique opportunities for evaluating genetic interactions. We examined relationships between LPL m107 (rs1800590) and APOA5 S19W (rs3135506) and lipid and anthropometric measures in Caribbean origin Hispanics (n = 1,019, aged 45–75 years) living in the Boston metropolitan area. Significant interaction terms between LPL m107 and APOA5 S19W were observed for BMI (P = 0.003) and waist circumference (P = 0.019). Higher BMI (P = 0.001), waist (P = 0.011) and hip (P = 0.026) circumference were observed in minor allele (G) carriers for LPL m107 who also carried the APOA5 S19W minor allele (G). Additionally, extreme obesity (BMI ≥ 40 kg/m2) risk was higher (odds ratio = 4.02; 95% confidence interval: 1.81–8.91; global P = 0.008) for minor allele carriers for both SNPs (LPL TG+GG, APOA5 CG+GG) compared to major allele carriers for both SNPs. In summary, we identified significant interactions for APOA5 S19W and LPL m107 for obesity in Caribbean Hispanics. Population‐specific MAFs increase the difficulties of replicating gene–gene interactions, but may support the hypothesis that combinations of frequencies in selected genes could heighten obesity susceptibility in a given population. Analyses of gene–gene interactions may improve understanding of genetically based obesity risk, and underscore the need for further study of groups with multiple ancestral admixtures.

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NO-1886 (ibrolipim), a lipoprotein lipase activator, increases the expression of uncoupling protein 3 in skeletal muscle and suppresses fat accumulation in high-fat diet–induced obesity in rats

Cited by 19 publications

References 23 publications

Down-regulation in muscle and liver lipogenic genes: EPA ethyl ester treatment in lean and overweight (high-fat-fed) rats

Down-regulation in muscle and liver lipogenic genes: EPA ethyl ester treatment in lean and overweight (high-fat-fed) rats

A mixture of the aqueous extract of Garcinia cambogia, soy peptide and l-carnitine reduces the accumulation of visceral fat mass in rats rendered obese by a high fat diet

Apolipoprotein A5 and Lipoprotein Lipase Interact to Modulate Anthropometric Measures in Hispanics of Caribbean Origin

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