No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer

Abstract

AIM:To investigate the association between single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homolog (PTEN) tumor suppressor gene and risk of colon cancer. METHODS:We utilized a population-based casecontrol study of incident colon cancer individuals (n = 421) and controls (n = 483) aged ≥ 30 years to conduct a comprehensive tagSNP association analysis of the PTEN gene. RESULTS:None of the PTEN SNPs were statistically significantly associated with colon cancer when control led for age, gender, and race, or when additionally adjusted for other known risk factors (P > 0.05). Haplotype analyses similarly showed no association between the PTEN gene and colon cancer. CONCLUSION:Our study does not support PTEN as a colon cancer susceptibility gene.

Association of PTEN genetic polymorphisms with atherosclerotic cerebral infarction in the Han Chinese population

“…Association studies for some of these polymorphisms have been reported previously. [14][15][16][17][18] Primers for polymerase chain reaction (PCR) were designed by Sequenom MassARRAY Assay Design 3.0 (Sequenom, San Diego, CA, USA).…”

Le syndrome de Cowden ou syndrome des hamartomes multiples en endocrinologie clinique

“…Si le risque néoplasique digestif ne semble pas paradoxalement augmenté [12], une surveillance endoscopique tous les 3 à 5 ans à partir de 30 ans est préconisée [13].…”

Differential expression of tumor-associated genes and altered gut microbiome with decreased Akkermansia muciniphila confer a tumor-preventive microenvironment in intestinal epithelial Pten-deficient mice

“…In contrast, there is considerable evidence suggesting that Pten may not be directly associated with tumorigenesis in the colon. A study examining single nucleotide polymorphisms (SNPs) in the Pten gene indicated that there may be no association between Pten and colon cancer in humans [18]. Furthermore, the Pten mRNA level is not consistent among colorectal cancer tissues and varies depending on tumor location [19], and Pten mRNA expression was seen to be preserved in human colorectal adenomas and adenocarcinomas [20].…”