No association of interleukin-6 gene polymorphism (-174 G/C) with premature coronary artery disease in a Turkish cohort

Seküri, Cevad; Çam, Fethi Sırrı; Sağcan, Abdi; Ercan, Ertuğrul; Tengiz, İstemihan; Alioğlu, Emin; Berdeli, Afig

doi:10.1097/mca.0b013e32820588ae

Cited by 33 publications

(24 citation statements)

References 39 publications

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“…A study conducted in Tunisia with 418 CAD patients and 406 controls indicated that the IL-6 174G/C variant is not associated with an increased risk of CAD (Ghazouani et al, 2011). Another Turkish cohort study found that the IL-6 174G/C polymorphism does not contribute to the risk of cardiovascular disease (Sekuri et al, 2007). The strengths of this study include the fact that the allele frequencies for all IL-6 polymorphisms examined were similar to those previously reported for the Chinese population Shi et al, 2013).…”

Section: Discussionsupporting

confidence: 48%

IL-6 gene promoter polymorphisms and risk of coronary artery disease in a Chinese population

Sun¹,

Wu²,

Meng³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. We investigated the relationships between single nucleotide polymorphisms (SNPs) of the interleukin (IL)-6 gene 174 G>C (rs1800795), 572 G>C (rs1800796), and 597 G/A (rs1800797) and coronary artery disease (CAD) risk in a Chinese population. This case-control study recruited 296 CAD patients and 327 controls between January 2009 and May 2012. Genotyping of IL-6 174 G>C (rs1800795), 572 G>C (rs1800796), and 597 G/A (rs1800797) was performed on a 384-well plate format using the Sequenom MassARRAY platform. CAD patients were more likely to be older and male, with a higher body mass index, diabetes, and hypertension, and presented higher triglycerides, and lower total cholesterol, low-density lipoprotein-cholesterol, and high-density lipoprotein-cholesterol. We found that the IL-6 174CC genotype was associated with a significantly increased risk of CAD compared to the wild-type GG genotype in a codominant model [odds ratio (95% confidence interval) = 1.94 (1.13- IL-6 gene and coronary artery disease 3.37)], whereas IL-6 174 G>C polymorphisms presented an increased risk of CAD in dominant and recessive models. However, we did not find that the IL-6 572 CC and 597 AA genotypes were correlated with an increased risk of CAD. IL-6 174 G>C rs1800795 was associated with CAD risk in a Chinese population. Further large-scale studies are required to determine whether IL-6 SNPs interact with environmental factors in the development of CAD.

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Section: Discussionsupporting

confidence: 48%

IL-6 gene promoter polymorphisms and risk of coronary artery disease in a Chinese population

Sun¹,

Wu²,

Meng³

et al. 2014

Genet. Mol. Res.

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“…In addition, the frequency of the -174G/C (26.3) and -174C/C (2.4) genotypes in our patient group was lower than that in French or Irish (Belfast) population, as reported in the Etude Cas Temoin de l’Infarctus du Myocarde (ECTIM) study,25 or in German or Scottish populations 1926. Our finding of an apparent lack of association of -174G>C alleles and genotypes with CAD was reminiscent of an earlier case-control study among Tunisian patients of breast carcinoma (immuno-inflammatory disease) (n=305) and healthy control subjects (n=200), where a comparable distribution and frequency of -174G>C alleles and genotypes were noted between patient and control groups,27 which were also comparable to those reported by Sekuri et al in the Turkish population 28…”

Section: Discussionsupporting

confidence: 90%

-174G>C interleukin-6 gene polymorphism in Tunisian patients with coronary artery disease

Ghazouani

Abboud

Khalifa

et al. 2011

Annals of Saudi Medicine

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BACKGROUND AND OBJECTIVES:A state of low-grade inflammation accompanies the pathogenesis of atherosclerotic events. Interleukin-6 (IL-6) is a pleotropic pro-inflammatory cytokine that modulates the development of acute coronary syndromes (ACSs), partly by destabilizing coronary atherosclerotic plaques. We have examined the contribution of the -174G>C IL-6 promoter variant on the risk of coronary artery disease (CAD) among Tunisians.PATIENTS AND METHODS:Study subjects included 418 CAD patients and 406 age- and sex-matched controls. IL-6 genotyping was done by PCR–restriction fragment length polymorphism.RESULTSThe frequency of the -174C allele (mutant) was lower in Tunisians than in Europeans, and the distribution of -174 G>C genotypes was similar between CAD patients and control subjects. Moreover, compared to GG genotype carriers, -174C allele carriage did not increase the CAD relative risk (odds ratio and 95% confidence interval=1.09 and 0.80-1.49), which remained nonsignificant after adjusting for traditional risk factors for CAD (age, smoking, hypertension, diabetes and obesity).CONCLUSIONThe -174G>C IL-6 promoter variant is not associated with an increased risk of CAD among Tunisians.

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“…After applying our inclusion/exclusion criteria, 19 articles were selected for inclusion in the final analysis [5,[23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40]. A diagram schematizing the selection process of identified and excluded articles with specification of reasons is presented in Fig.…”

Section: Search Results and Study Characteristicsmentioning

confidence: 99%

Association of interleukin-6 circulating levels with coronary artery disease: A meta-analysis implementing mendelian randomization approach

Niu

Liu

et al. 2012

International Journal of Cardiology

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No association of interleukin-6 gene polymorphism (-174 G/C) with premature coronary artery disease in a Turkish cohort

Abstract: We conclude that the IL-6 -174 G/C polymorphism is not associated with the risk of premature CAD, and does not contribute to cardiovascular risk stratification.

Cited by 33 publications

References 39 publications

IL-6 gene promoter polymorphisms and risk of coronary artery disease in a Chinese population

IL-6 gene promoter polymorphisms and risk of coronary artery disease in a Chinese population

-174G>C interleukin-6 gene polymorphism in Tunisian patients with coronary artery disease

Association of interleukin-6 circulating levels with coronary artery disease: A meta-analysis implementing mendelian randomization approach

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