No association of the Trp 64 Arg mutation of the (.BETA.3-adrenergic receptor gene with obesity, type 2 diabetes mellitus, hyperlipidemia, and hypertension in Japanese patients with schizophrenia

Abstract

Objective : This study was conducted to address the question of whether the 3-adrenergic receptor gene mutation (Trp64Arg) is associated with metabolic disease in Japanese patients with schizophrenia. Methods : In a cross-sectional study, 89 participants were grouped into three genotypes. The 64 Arg allelic frequency in patients with or without metabolic disease was analyzed. Anthropometrics variables and biochemical parameters were compared among the genotypes. Results : The64Arg allele, which had a frequency of 0.22, was not associated with obesity, type2 diabetes mellitus, dyslipidemias, or hypertension. No significant differences among the genotypes were found in current age, age at diagnosis with schizophrenia, body mass index, waist-hip ratio, plasma glucose, plasma insulin, triglycerides, free fatty acids. Patients with the 64 Arg allele had greater 24-h excretion of norepinephrine than those lacking the variant (p=0.019). Conclusion : The 64 Arg allelic mutation is not associated with obesity, type2 diabetes mellitus, lipid metabolism dysfunction, or hypertension in Japanese patients with schizophrenia.

The mutation of Trp64Arg in β3-adrenoreceptor-encoding gene is significantly associated with increased hypertension risk and elevated blood pressure: a meta-analysis

“…There were 16 publications testing the association of ADRB3 gene Trp64Arg polymorphism with hypertension risk [ 10 , 11 , 14 , 16 , 17 , 19 , 20 , 23 – 31 ], incorporating 21 individual studies (3750 hypertensive patients and 4225 normotensive controls). Fourteen publications were available for the association of Trp64Arg polymorphism with blood pressure changes [ 4 , 10 , 12 – 15 , 17 , 18 , 21 – 23 , 25 , 26 , 28 ], incorporating 17 individual studies (6100 subjects). The baseline characteristics of all qualified studies are present in both Supplementary Table 1 and Table 1 .…”

The Human Obesity Gene Map: The 2005 Update

“…In addition to the positive studies summarized above, we identified 92 studies dealing with 58 genes in which there was no evidence of associations between DNA sequence variations and obesity‐related phenotypes. Among these studies, the most frequent ones were those pertaining to markers of PPARG (1012, 1114, 1115, 1116, 1117, 1118, 1119, 1120, 1121, 1122, 1123, 1124, 1125, 1126) (14 studies), ADIPOQ (1127, 1128, 1129, 1130), ADRB3 (1084, 1121, 1131, 1132), IL6 (1129, 1133, 1134, 1135) (four studies each), and ESR1 (1136, 1137, 1138) (three studies). Other markers yielding negative findings were those related to ACE (710, 1032), ACTN (1139), ADIPOR1 (1140), ADIPOR2 (1140), ADRB1 (1132), A DRB2 (1132), AGER (1141), AHSG (1142), APOA4 (1143), APOE (1144, 1145), AR (1146), BDNF (1147), CASQ1 (1148), COL1A1 (1134), CRP (1149), ENPP1 (1150), FABP2 (1151), GNAS (1152), GNB3 (1152, 1153), GPR40 (1154), H6PD (1155), HSD11B1 (1155, 1156), ICAM1 (1157), IGF1 (1158), IL6R (1159), INS (1160, 1161), KCNJ11 (1120), KL (1146), LEP (1129), LEPR (1162), LIPC (1163), LPL (1164), LTA (964), MKKS (1165), MT‐DLOOP (1166), MTHFR (1167), MTTP (1168), NOS3 (1169, 1170), NPY (1171), NR0B2 (…”

The Trp64Arg polymorphism of the β3-adrenergic receptor gene is associated with increased small dense low-density lipoprotein in a rural Japanese population: the Mima study

“…In Japanese patients with non-insulin-dependent diabetes mellitus, this polymorphism is associated with higher serum triglyceride levels and decreased high-density lipoprotein (HDL) cholesterol levels [17]. On the other hand, this polymorphism had no apparent effect on triglyceride levels in Japanese patients with schizophrenia [18].…”