Nobiletin promotes the pyroptosis of breast cancer via regulation of <scp>miR</scp>‐200b/<scp>JAZF1</scp> axis

Wang, Ji-Guo; Jian, Wenjing; Li, Yang; Zhang, Jing

doi:10.1002/kjm2.12371

Cited by 31 publications

(16 citation statements)

References 33 publications

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“…Cell viability using the MTT assay seemed to form a baseline against which a metabolite qualifies for further investigation. The studied flavonoids mainly displayed a dose and time-dependent effect on the variant breast cancer cell lines tested (Anaya-Eugenio et al, 2021;Attari et al, 2021;Go et al, 2018;Hallman et al, 2017;Hart et al, 2018;Hwang et al, 2020;Jia et al, 2018;Karimi et al, 2017;Li et al, 2017Li et al, , 2018Liang et al, 2021;Moradi et al, 2020;Qiu et al, 2019;Wang et al, 2021;Yu et al, 2018). The sensitivity of the flavonoids differed based on flavonoid type, concentration and cell line used.…”

Section: Cell Viabilitymentioning

confidence: 99%

“…The mechanisms involved included reduction in expression of antiapoptotic genes such as Bcl2, XIAP and increased expression of Bax, PARP 1, caspases 3, 7, 8, 9. Other mechanisms included increased mitochondrial oxidative stress, downregulation of mitochondrial membrane potential, inhibition of NF-κB, modulation of miR-200b/JAZF1 pathway and activation of PAX8-AS1-N/miR-17-5p/PTEN, CDKNIA,ZBTB4 regulation axis (Abbaszadeh et al, 2018;Anaya-Eugenio et al, 2021;Attari et al, 2021;Harrath et al, 2021;Hwang et al, 2020;Ko et al, 2020;Lee et al, 2020;Liang et al, 2021;Moradi et al, 2020;Pham et al, 2021;Qiu et al, 2019;Truong et al, 2021;Vrhovac Madunić et al, 2018;Wang et al, 2021;Xu et al, 2019b;Yu et al, 2018;Zhang et al, 2020;Zhu & Xue, 2019).…”

Section: Apoptosismentioning

confidence: 99%

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Molecular mechanisms of flavonoids and their modulatory effects against breast cancer: A scoping review

Murithi

Wambugu²,

Nyanjom

et al. 2022

F1000Res

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Background: Breast cancer is the most prevalent malignancy among women. It is a disease whose incidence and mortality rates are on the upsurge globally. Debilitating effects, cost and resistance to available chemotherapeutic interventions render them unideal. Dietary phytochemicals have been shown to have preventive and therapeutic effects. Research continues to affirm the role of flavonoids as potential chemotherapeutic agents in combating the disease. Understanding modulation of key cellular signalling pathways by flavonoids presents promising molecular targets that may be leveraged to develop better chemotherapeutic agents for breast cancer. Methods: To describe the in vitro and in vivo modulatory effects of flavonoids on molecular anti-cancer mechanisms we searched three databases. We included original articles describing modulation of cell signalling processes such as; cell cycle, apoptosis, autophagy, angiogenesis, invasion and migration which are involved in tumorigenesis. The search guidelines such as; year of publication, search strategy, study design and language informed article selection. Results: Thirty-six articles were reviewed. Modulatory effects of six subclasses of flavonoids on breast cancer tumorigenic pathways were reported. The effects included enhanced apoptosis, attenuation of; angiogenesis, cell cycle, invasion, migration and metastasis. For instance, pectolinarigenin inhibited signal transducer and activator of transcription 3 (stat3) signalling pathway in triple negative breast cancer. Whereas, sideritoflavone caused cell cycle arrest and inhibited migration in trastuzumab resistant breast cancer cells. Additionally, quercetin and ampelopsin inhibited stemness features in triple negative breast cancer cells. Conclusion: Evidently flavonoids showed significant modulatory effects on cellular signalling pathways crucial for breast cancer progression. The ability of flavonoids to act on a wide range of mechanisms as well as on aggressive breast cancer types presents an array of hope. We recommend that further studies be done to ascertain the applicability of these compounds in treatment of breast cancers.

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Section: Cell Viabilitymentioning

confidence: 99%

Section: Apoptosismentioning

confidence: 99%

Molecular mechanisms of flavonoids and their modulatory effects against breast cancer: A scoping review

Murithi

Wambugu²,

Nyanjom

et al. 2022

F1000Res

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“…Nobiletin suppresses breast cancer progression in a dose-dependent manner. Nobiletin enhances miRNA-200b expression to elevate apoptosis and pyroptosis in breast cancer cells [ 121 ]. Three experiments have shown role of nobiletin in affecting CSCs in tumor therapy.…”

Section: Dietary Agents and Cancer Stem Cellsmentioning

confidence: 99%

Targeting Cancer Stem Cells by Dietary Agents: An Important Therapeutic Strategy against Human Malignancies

Paskeh

Asadi²,

Zabolian

et al. 2021

IJMS

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As a multifactorial disease, treatment of cancer depends on understanding unique mechanisms involved in its progression. The cancer stem cells (CSCs) are responsible for tumor stemness and by enhancing colony formation, proliferation as well as metastasis, and these cells can also mediate resistance to therapy. Furthermore, the presence of CSCs leads to cancer recurrence and therefore their complete eradication can have immense therapeutic benefits. The present review focuses on targeting CSCs by natural products in cancer therapy. The growth and colony formation capacities of CSCs have been reported can be attenuated by the dietary agents. These compounds can induce apoptosis in CSCs and reduce tumor migration and invasion via EMT inhibition. A variety of molecular pathways including STAT3, Wnt/β-catenin, Sonic Hedgehog, Gli1 and NF-κB undergo down-regulation by dietary agents in suppressing CSC features. Upon exposure to natural agents, a significant decrease occurs in levels of CSC markers including CD44, CD133, ALDH1, Oct4 and Nanog to impair cancer stemness. Furthermore, CSC suppression by dietary agents can enhance sensitivity of tumors to chemotherapy and radiotherapy. In addition to in vitro studies, as well as experiments on the different preclinical models have shown capacity of natural products in suppressing cancer stemness. Furthermore, use of nanostructures for improving therapeutic impact of dietary agents is recommended to rapidly translate preclinical findings for clinical use.

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“…Traditional Chinese Medicine (TCM) active ingredients have attracted increasing attention on their critical biological effects on the progression of various diseases (Dai et al 2021 ; Wei et al 2021 ; Wang et al 2021 ). Some of the monomers of TCM have important neuroprotective effects, such as ginsenoside Rg1 (Yang et al 2020 ), chikusetsu saponin V (Zhang et al 2021 ) and mangiferin (Peng et al 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Protective role of trametenolic acid B against sevoflurane-induced cognitive impairments by its different regulatory modalities of mir-329-3p in neurons and microglia

Feng

Qiu

et al. 2022

Mol Med

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Background Postoperative cognitive dysfunction induced by anesthetics commonly occurs in elderly patients. This study aimed to evaluate the protective role of trametenolic acid B (TAB) in sevoflurane-induced cognitive impairments, and explore the underlying mechanisms. Methods Animal and cell experiments were performed in rats, differentiated PC12 and HAPI cells by exposing to 2% sevoflurane for 5 h. Different concentration (20, 40 and 80 µg/mL) of TAB was administrated in rats and cells. The cognitive function of rats was evaluated using the Morris water maze test and fear conditioning test. The cell proliferation and apoptosis were investigated using a CCK-8 assay and the flow cytometry. Pro-inflammatory cytokines in microglia were measured using ELISA kits. A miRNA microarray assay was conducted to screen differentially expressed miRNAs by TAB in both PC12 and HAPI cells. The luciferase reporter assay and western blot assay were used to assess the E2F1/CCNA2 and NF-κB pathways. Results TAB significantly alleviated sevoflurane-induced cognitive impairments in rats, improved PC12 cell viability, and inhibited the neuroinflammation of HAPI cells. miR-329-3p was downregulated in PC12 cells but upregulated in HAPI cells by TAB treatment, which mediated the effects of TAB on neurotoxicity and neuroinflammation. E2F1 and NF-κB P65 were two targets of miR-329-3p, and the E2F1/CCNA2 and NF-κB pathways were inhibited by miR-329-3p in PC12 and HAPI cells, respectively. Conclusions All the results provide evidence for the protective role of TAB against sevoflurane-induced cognitive impairments, which was achieved by alleviating neurotoxicity and neuroinflammation through differentially regulating miR-329-3p in neurons and microglia.

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Nobiletin promotes the pyroptosis of breast cancer via regulation of miR‐200b/JAZF1 axis

Cited by 31 publications

References 33 publications

Molecular mechanisms of flavonoids and their modulatory effects against breast cancer: A scoping review

Molecular mechanisms of flavonoids and their modulatory effects against breast cancer: A scoping review

Targeting Cancer Stem Cells by Dietary Agents: An Important Therapeutic Strategy against Human Malignancies

Protective role of trametenolic acid B against sevoflurane-induced cognitive impairments by its different regulatory modalities of mir-329-3p in neurons and microglia

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