Nocturia Compounds Nocturnal Wakefulness in Older Individuals with Insomnia

Zeitzer, Jamie M.; Bliwise, Donald L.; Hernandez, Beatriz; Friedman, Leah; Yesavage, Jerome A.

doi:10.5664/jcsm.2492

Cited by 19 publications

(17 citation statements)

References 21 publications

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“…Although the relationship between nocturia frequency and objectively‐measured sleep has been studied in other adult populations, few studies have examined this relationship in individuals age 85 years or older, which is the age group with the highest levels of disability requiring long‐term care . Our wake‐time findings are similar to those reported by Zeitzer et al (in a sample with mean age 62 years), where a 34 minute difference in mean wake‐after‐sleep‐onset between voiding three times/night vs 0 times/night was found . We did not find an association between frequency of nocturia and objectively measured total sleep time, in contrast to a study by Yu et al, which found that nocturia frequency was weakly correlated with self‐reported total sleep time ( r = 0.13, P = .003) .…”

Section: Discussionsupporting

confidence: 83%

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Nocturia is Associated with Poor Sleep Quality Among Older Women in the Study of Osteoporotic Fractures

Fung

Vaughan

Markland

et al. 2017

J American Geriatrics Society

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Objectives 1) To examine relationships between frequency of nocturia and self-reported sleep quality and objective sleep measures in older women and 2) to estimate the amount of variation in sleep measures that is specifically attributable to frequency of nocturia. Design and Setting Secondary, cross sectional analysis of the multicenter prospective cohort Study of Osteoporotic Fractures (SOF) Participants Community-dwelling women aged ≥ 80 years Measurements Frequency of nocturia in the previous 12 months, Pittsburgh Sleep Quality Index sleep quality subscale, and actigraphy-measured wake after sleep onset (WASO) and total sleep time (TST). Results Of 1,520 participants, 25% (N=392) reported their nocturia frequency was 3–4 times/night and an additional 60% (N=917) reported their nocturia frequency was 1–2 times/night. More frequent nocturia was associated with poor sleep quality (3–4/night: 26.8% reported fairly bad or very bad sleep quality; 1–2/night: 14.7%; 0/night: 7.7%; p<.001) and longer WASO (3–4/night: 89.8 minutes; 1–2/night: 70.6; 0/night: 55.5; p<.001). In nested regression models, a nocturia frequency of 3–4/night quadrupled the odds of poor sleep quality (odds ratio: 4.26 [95% CI 1.65, 11.01]; p=.003) and was associated with a 37-minute worsening in WASO (95% CI 26.0, 49.0; p<.001). Frequency of nocturia explained an additional 6% variation in WASO, above and beyond demographic, medical/psychiatric conditions, and medication factors (ΔR2=.06). Conclusions Nocturia is common among octogenarian and nonagenarian women and is independently associated with poor sleep quality and longer wake time at night. Interventions that improve nocturia may be useful in improving sleep quality and wake time at night.

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Section: Discussionsupporting

confidence: 83%

“…Nocturia is associated with self‐reported short total sleep time in one‐fifth of adults . More frequent nocturia is positively associated with actigraphically measured sleep disruption (overall wakefulness after sleep onset) . Nocturia predicts worse self‐reported sleep quality .…”

mentioning

confidence: 99%

Nocturia is Associated with Poor Sleep Quality Among Older Women in the Study of Osteoporotic Fractures

Fung

Vaughan

Markland

et al. 2017

J American Geriatrics Society

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“…Zeitzer et al [25] investigated the link between sleep and nocturia. Their study of patients with insomnia used a cohort of 55 men with a mean age of 64.3 and 92 women with a mean age of 62.5; in this study, they looked at the effects of nocturia on objective measures of sleep.…”

Section: Sleep-associated Nocturiamentioning

confidence: 99%

Nocturia causes vary with each decade

Graham

Desroches

Weiss

2014

Current Opinion in Urology

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There is a lack of standardization in definition and classification of the causes of nocturia. Confounding variables included a lack of use of a standard definition of nocturia, identifying nocturia at its true onset, and a fundamental underutilization of frequency volume charts to identify patients with nocturia. The confounding variables make it difficult to compare studies. Thus, the strength of conclusion on cause will be better defined when standards are set controlling definition, identification, and diagnosis.

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“…From the BACH trial, Fitzgerald et al surveyed 5,502 men and women between the ages of 30 and 79 and found the incidence of nocturia (>1 void per night) to be 25.2% in men and 31.3% in women (66). Not only is it relatively prevalent, nocturia is also very bothersome to patients, as it has been associated with increased depressive symptoms, worse sleep, and increased fatigue (67,68). …”

Section: Nocturiamentioning

confidence: 99%

Testosterone replacement therapy and voiding dysfunction

Baas

Köhler

2016

Transl. Androl. Urol.

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Testosterone replacement therapy (TRT) represents an increasing popular treatment option for men with late-onset hypogonadism (LOH). Because of unsubstantiated beliefs of testosterone’s effect on the prostate, the FDA has recently placed a warning on testosterone products, stating that TRT may worsen benign prostatic hyperplasia (BPH). Within this review article we have demonstrated the current understanding of the physiology of testosterone and its relationship with prostatic and lower urinary tract physiology. The current evidence suggests that not only does TRT not worsen lower urinary tract symptoms (LUTS), but that hypogonadism itself is an important risk factor for LUTS/BPH.

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Nocturia Compounds Nocturnal Wakefulness in Older Individuals with Insomnia

Cited by 19 publications

References 21 publications

Nocturia is Associated with Poor Sleep Quality Among Older Women in the Study of Osteoporotic Fractures

Nocturia is Associated with Poor Sleep Quality Among Older Women in the Study of Osteoporotic Fractures

Nocturia causes vary with each decade

Testosterone replacement therapy and voiding dysfunction

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