Nocturnal seizures and the effects of anticonvulsants on sleep

Bazil, Carl W.

doi:10.1007/s11910-008-0024-z

Cited by 31 publications

(17 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…23 Successful treatment of nocturnal seizures will improve sleep and reduce daytime sleepiness in children with Dravet syndrome. In our cohort, 20 children (35%) had sleep-wake transition disorders, with 54% of children younger than 5 years old affected.…”

Section: Discussionmentioning

confidence: 99%

Sleep problems in Dravet syndrome: a modifiable comorbidity

Licheni

McMahon

Schneider

et al. 2017

Develop Med Child Neuro

View full text Add to dashboard Cite

More than 70% of patients with Dravet syndrome have sleep problems. Difficulty initiating and maintaining sleep was most common, particularly in those older than 20 years. Second most common were sleep-wake transition disorders, affecting more than 50% of those younger than 5 years. Sleep breathing disorders were a frequent problem across all age groups. Oximetry was not diagnostic of sleep-disordered breathing or obvious seizures.

show abstract

Section: Discussionmentioning

confidence: 99%

Sleep problems in Dravet syndrome: a modifiable comorbidity

Licheni

McMahon

Schneider

et al. 2017

Develop Med Child Neuro

View full text Add to dashboard Cite

show abstract

“…It is well established that in some epilepsies, certain normal states of vigilance are more conducive to seizure than others34,35,36. Seizure recurrence is also correlated with physiological rhythms24,37 and drug taper38.…”

Section: Clinical Aspects Of Epilepsy and Objectives For Electrothmentioning

confidence: 99%

“…Confounding factors: Drug taper38, physiological rhythms37, sleep stage34, stress, and various other factors are known to influence seizure rate and/or severity, and thereby interfere with the quantitative assessment of treatment effects.…”

Section: Clinical Aspects Of Epilepsy and Objectives For Electrothmentioning

confidence: 99%

Toward rational design of electrical stimulation strategies for epilepsy control

Sunderam¹,

Gluckman²,

Reato³

et al. 2010

Epilepsy & Behavior

View full text Add to dashboard Cite

Electrical stimulation is emerging as a viable alternative for epilepsy patients whose seizures are not alleviated by drugs or surgery. Its attractions are temporal and spatial specificity of action, flexibility of waveform parameters and timing, and the perception that its effects are reversible unlike resective surgery. However, despite significant advances in our understanding of mechanisms of neural electrical stimulation, clinical electrotherapy for seizures relies heavily on empirical tuning of parameters and protocols. We highlight concurrent treatment goals with potentially conflicting design constraints that must be resolved when formulating rational strategies for epilepsy electrotherapy: namely seizure reduction versus cognitive impairment, stimulation efficacy versus tissue safety, and mechanistic insight versus clinical pragmatism. First, treatment markers, objectives, and metrics relevant to electrical stimulation for epilepsy are discussed from a clinical perspective. Then the experimental perspective is presented, with the biophysical mechanisms and modalities of open-loop electrical stimulation, and the potential benefits of closed-loop control for epilepsy.

show abstract

“…Among them, sleep apnea, agrypnia and daytime drowsiness are some of the most common causes of dyssomnia (16). Among the common population, the incidence rate of sleep apnea is at least 3%, while polysomnography analysis of investigated epileptic patients revealed that the incidence rate of sleep apnea may be up to 70%.…”

Section: Discussionmentioning

confidence: 99%

Effect of sodium valproate on the sleep structures of epileptic patients

Zhang

et al. 2014

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

The aims of the present study were to investigate the effect of sodium valproate (VPA) on the sleep structures of epileptic patients and the correlation of these effects with patient weight gain. A total of 60 epileptic patients were divided into three groups: E-AED I (VPA administration for a duration of <3 months), E-AED II (VPA administration for a duration of >3 months) and ECO (without VPA) groups, for polysomnography monitoring. When the E-AED II group was compared with the E-AED I and ECO groups, non-rapid eye movement sleep phase 1 was significantly prolonged (92.10±48.24, 29.50±10.61 and 23.94±13.27 min, respectively; P<0.01), rapid eye movement sleep was significantly shortened (70.82±17.69, 116.99±12.90 and 126.19±35.01 min, respectively; P<0.01), sleep efficiency was significantly reduced (89.39±2.55, 91.98±2.53 and 91.96±3.14%, respectively; P<0.01), the number of times of that the patients awoke was significantly increased (7.25±2.86, 2.55±1.42 and 2.40±1.39, respectively; P<0.01) and the number of REM phases throughout the night was significantly reduced (P<0.01). There were no significant differences for the various sleep parameters between the E-AED I and ECO groups. Therefore, VPA is capable of inducing sleep structure disorders in epileptic patients. In addition, these disorders begin 3 months following the administration of VPA, which indicates that these disorders may be associated with VPA-induced weight gain.

show abstract

Nocturnal seizures and the effects of anticonvulsants on sleep

Cited by 31 publications

References 51 publications

Sleep problems in Dravet syndrome: a modifiable comorbidity

Sleep problems in Dravet syndrome: a modifiable comorbidity

Toward rational design of electrical stimulation strategies for epilepsy control

Effect of sodium valproate on the sleep structures of epileptic patients

Contact Info

Product

Resources

About