Noise-induced hearing loss and combined noise and vibration exposure

Turcot, Alice; Girard, Serge-André; Courteau, Marilène; Baril, Julie; Larocque, R.Y.

doi:10.1093/occmed/kqu214

Cited by 36 publications

(56 citation statements)

References 19 publications

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“…The older guinea pigs were two-fold more sensitive to vibration than younger animals [49]. The combination of noise and vibration during the use of hand-held vibrating tools increased the risk of hearing loss in industrial workers [6,52]. Increased oxidative stress and chronic inflammation are also associated with ageing [53], and age-related cochlear structural alterations and degeneration of sensory and neural cells also occurred [54] that resembles normal aging.…”

Section: Evidence For the Role Of Oxidative Stress In Hearing Disordersmentioning

confidence: 99%

“…In order to develop an effective preventive strategy, the major cellular defects that initiate and promote hearing loss should be identified. Several studies of the past decades indicate that increased oxidative stress [1][2][3][4][5][6], inflammation [7][8][9][10][11][12][13], and glutamate [14][15][16] play a central role in the initiation and progression of hearing defects. Therefore, reducing these biochemical defects simultaneously may be one of the rational strategies for the…”

mentioning

confidence: 99%

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Involvement of Oxidative Stress, Inflammation, and Glutamate in Ototoxicity, and their Attenuation by Simultaneous Activation of Nrf2 and Elevation of Antioxidant Compounds

Prasad¹,

Global²

2019

Int J Neurol Neurother

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Diverse groups of ototoxic agents and gene mutation induce hearing disorders. Several studies showed that increased oxidative stress, inflammation, and glutamate are involved in the initiation and progression of hearing disorders. Therefore, reducing these biochemical defects before and after exposure to ototoxic agents may prevent and improve the management of hearing loss. Previous studies with a single agent have yielded variable benefits in hearing disorders. This review briefly presents evidence for the involvement of oxidative stress, inflammation, and glutamate in the initiation and progression of hearing disorders. It proposes a novel concept that simultaneous elevation of the levels of antioxidant enzymes, dietary and endogenous antioxidant compounds, and reduction in the levels of glutamate may be necessary for the optimal benefits in prevention and improved management of hearing disorders. Supplementation with micronutrients can elevate the levels of antioxidant compounds and reduce the levels of glutamate. However, increasing the levels of antioxidant enzymes is complex requiring an activation of the nuclear transcriptional factor-2 (Nrf2). This review briefly describes the regulation of activation of Nrf2, and proposes a micronutrient mixture that can simultaneously activate Nrf2, enhance the dietary and endogenous antioxidant compounds levels, and inhibit the release and toxicity of glutamate for prevention and improved management of hearing loss.

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Section: Evidence For the Role Of Oxidative Stress In Hearing Disordersmentioning

confidence: 99%

mentioning

confidence: 99%

Involvement of Oxidative Stress, Inflammation, and Glutamate in Ototoxicity, and their Attenuation by Simultaneous Activation of Nrf2 and Elevation of Antioxidant Compounds

Prasad¹,

Global²

2019

Int J Neurol Neurother

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“…For example, a study of 199 Finnish forest workers found that aging was the main risk factor, followed by occupational noise exposure, and the presence of vibration in the work [20]. Furthermore, in the studies by Iki and Turcot greater hearing alterations were observed over time among forest workers who also suffered from white finger disease induced by hand and arm vibration [21,22]. In addition to causing communication difficulties, impairments related to hearing loss can in turn generate stress, anxiety, irritability, decreased self-esteem, social isolation, and loss of productivity, as well as impair the performance of activities of daily living, resulting in costs for the individual, family, company and society [23].…”

Section: Occupational Heat Exposure Assessment (A) Logging Industrymentioning

confidence: 99%

Risk Analysis in a Tropical Forest Wood Exploration and Processing System in Mato Grosso State, Brazil

Soranso

Minette

Bermudes

et al. 2019

JEAI

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Forestry and logging activities in tropical regions are commonly carried out in inappropriate thermal conditions, due to the hot and humid climate, demanding from the worker high energy expenditure and physical effort. They often operate and handle machines and equipment that produce high levels of noise and vibration, and adopt postures that can be harmful to the body, given the constant lifting, handling and transport of loads above tolerable limits. The objective of this study was to evaluate the exposure of workers to risks in a rainforest harvesting and processing system in northern Mato Grosso State, Brazil. The study was conducted in two forest management areas and four processing industries. Occupational heat exposure was assessed and a qualitative analysis of noise and vibration was performed in the two study areas. Occupational exposure to heat was performed by determining the Wet Bulb Index and Globe Thermometer (IBUTG), while the qualitative analysis of noise and vibration was performed with the application of a Risk Analysis methodology. The results indicate that the values of the wet bulb index and globe thermometer (IBUTG), obtained every hour of the working day in the activities of the timber industry and wood processing, correspond to values above the tolerance limit, as standardized. The condition most likely to be harmful to health was found in the exposure to noise by workers in the wood processing industry, especially in operations related to the logging stages, where the risk was categorized as intolerable. With respect to exposure to vibration, the risk was higher in chainsaw operations in logging. In this case, it was possible to qualitatively analyze which occupational exposure limit (OEL) would be exceeded when the machine was in operation, representing risks to workers’ health and safety. It is concluded that there is a need to adopt control measures, since the risk exposure levels were in a range that poses a risk to workers’ health.

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“…Besides noise, other well-established risk factors include vibration,4 smoking, organic solvent,5 long-term stress exposure and socioeconomic status 6. However, for workers exposed to a similar level of noise or other environmental factors, the extent of their hearing loss varies 7.…”

Section: Introductionmentioning

confidence: 99%

Genetic variation in EYA4 on the risk of noise-induced hearing loss in Chinese steelworks firm sample

Yang

Jiao

et al. 2016

Occup Environ Med

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Noise-induced hearing loss and combined noise and vibration exposure

Abstract: This study confirms previous findings of greater hearing loss at higher frequencies in workers with VWF, but also found a significant difference in hearing loss at low frequencies. It therefore supports the association between combined noise and hand-arm vibration (HAV) exposure and NIHL.

Cited by 36 publications

References 19 publications

Involvement of Oxidative Stress, Inflammation, and Glutamate in Ototoxicity, and their Attenuation by Simultaneous Activation of Nrf2 and Elevation of Antioxidant Compounds

Involvement of Oxidative Stress, Inflammation, and Glutamate in Ototoxicity, and their Attenuation by Simultaneous Activation of Nrf2 and Elevation of Antioxidant Compounds

Risk Analysis in a Tropical Forest Wood Exploration and Processing System in Mato Grosso State, Brazil

Genetic variation in EYA4 on the risk of noise-induced hearing loss in Chinese steelworks firm sample

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