Non-contact photoacoustic imaging using laser speckle contrast analysis

Benyamin, Matan; Genish, Hadar; Califa, Ran; Schwartz, Adi; Zalevsky, Zeev; Ozana, Nisan

doi:10.1364/ol.44.003110

Cited by 12 publications

(12 citation statements)

References 16 publications

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“…To address the problem of the sample surface quality in full field imaging, a simple non-scanning speckle-based approach was proposed [96] . Indeed, surface vibration caused by US signals can be computed by calculating the contrast of the reflected speckle pattern [97] generated by a probe laser beam. The speckle pattern can be created by a diffuser positioned in the probe beam.…”

Section: Summary and Prospectsmentioning

confidence: 99%

Non-contact detection of ultrasound with light – Review of recent progress

2023

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Section: Summary and Prospectsmentioning

confidence: 99%

Non-contact detection of ultrasound with light – Review of recent progress

2023

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“…When a continuous-wave laser illuminates this region, these surface deformations modulate the speckle patterns of the backscattered beam. By characterizing these patterns, information about the surface deformations, and thus the acoustic pressure, can be extracted [ [144] , [145] , [146] , [147] , [148] ].…”

Section: Non-contact Photoacoustic Signal Detectionmentioning

confidence: 99%

Towards non-contact photoacoustic imaging [review]

Hosseinaee

Bell

et al. 2020

Photoacoustics

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Photoacoustic imaging (PAI) takes advantage of both optical and ultrasound imaging properties to visualize optical absorption with high resolution and contrast. Photoacoustic microscopy (PAM) is usually categorized with all-optical microscopy techniques such as optical coherence tomography or confocal microscopes. Despite offering high sensitivity, novel imaging contrast, and high resolution, PAM is not generally an all-optical imaging method unlike the other microscopy techniques. One of the significant limitations of photoacoustic microscopes arises from their need to be in physical contact with the sample through a coupling media. This physical contact, coupling, or immersion of the sample is undesirable or impractical for many clinical and pre-clinical applications. This also limits the flexibility of photoacoustic techniques to be integrated with other all-optical imaging microscopes for providing complementary imaging contrast. To overcome these limitations, several non-contact photoacoustic signal detection approaches have been proposed. This paper presents a brief overview of current non-contact photoacoustic detection techniques with an emphasis on all-optical detection methods and their associated physical mechanisms.

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“…7 Speckle analysis uses changes in the interference pattern detected by a CCD camera of the reflected light to detect vibrations. 8,9 However, this method has a limited bandwidth and can be prone to noise due to spurious motions. Non-interferometric photoacoustic remote sensing is a more recent technique that has demonstrated good detection sensitivity for non-contact photoacoustic microscopy.…”

Section: Introductionmentioning

confidence: 99%

Silicon photonics based laser doppler vibrometer for non-contact photoacoustic sensing

Dieussaert

Baets

2023

Smart Photonic and Optoelectronic Integrated Circuits 2023

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Non-contact detection of photoacoustic signals is important for various applications, particularly in medical sensing and imaging, where contact methods can be uncomfortable or risky for the patient. Techniques using optical detection of vibrations, such as laser doppler vibrometers (LDVs), have been proven to be a key component for enabling non-contact photoacoustic sensing. However, most LDV systems rely on fiber-based or free-space optics, which can be unwieldy and expensive, especially for multiple location sensing. In this work, we present a compact, photonic integrated circuit (PIC)-based homodyne LDV system for the detection of photoacoustic signals. The system is fabricated on a silicon-on-insulator platform, which has the potential to be low-cost in case of medium or large volume production. To generate the photoacoustic signals, we used a 532 nm pulsed laser directed towards a target embedded in a silicone phantom designed to mimic the acoustic properties of human tissue. The target consists of an ink-solution-filled channel, which absorbs the excitation light and generates acoustical signals within the phantom through the photoacoustic effect. After performing a series of measurements with different ink concentrations, we found a good correlation between the photoacoustic signals detected by the on-chip detectors and the absorption of the target. Our system was able to detect ink solutions with absorption values as low as 5 cm −1 , an order of magnitude lower than the typical absorption of whole blood at 532 nm. These results demonstrate that PIC-based LDVs can be used to realize compact and low-cost non-contact detection for photoacoustic biomedical sensing applications.

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Non-contact photoacoustic imaging using laser speckle contrast analysis

Cited by 12 publications

References 16 publications

Non-contact detection of ultrasound with light – Review of recent progress

Non-contact detection of ultrasound with light – Review of recent progress

Towards non-contact photoacoustic imaging [review]

Silicon photonics based laser doppler vibrometer for non-contact photoacoustic sensing

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