Non-Enzymatic Natural Reactive Oxygen Scavengers (Ros): A Review on Structures and Mode of Action

Ahamad, Tanveer; Ansari, Waseem Ahmad; Negi, Devendra Singh; Khan, Mohammad Faheem

doi:10.24041/ejmr2019.139

EJMR

2019

DOI: 10.24041/ejmr2019.139

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Non-Enzymatic Natural Reactive Oxygen Scavengers (Ros): A Review on Structures and Mode of Action

Tanveer Ahamad¹,

Waseem Ahmad Ansari²,

Devendra Singh Negi³

et al.

Abstract: ROS hasboth positive and negative effects. In moderated amounts, they get involved in elimination of invading pathogens,healing and repairing of wounds, promote cell death in pathophysiological conditions, induces apoptosis, necrosis as well as autophagy (3). In cancerous cells, limited amount of ROS regulates 2 2 through mitochondrial respiration, phagocytosis.The majorenzymes which cause generation of ROS are iron and Cu proteins, NADPH oxidase (NO), xanthine oxidase (XO), Lipoxygenase (LO), cytochrome P450 … Show more

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Cited by 3 publications

References 24 publications

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Quantum Sensing Unravels Antioxidant Efficacy Within PCL/Matrigel Skin Equivalents

Wu,

Koch,

Martínez

et al. 2024

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Skin equivalents (SE) that recapitulate biological and mechanical characteristics of the native tissue are promising platforms for assessing cosmetics and studying fundamental biological processes. Methods to achieve SEs with well‐organized structure, and ideal biological and mechanical properties are limited. Here, the combination of melt electrowritten PCL scaffolds and cell‐laden Matrigel to fabricate SE is described. The PCL scaffold provides ideal structural and mechanical properties, preventing deformation of the model. The model consists of a top layer for seeding keratinocytes to mimic the epidermis, and a bottom layer of Matrigel‐based dermal compartment with fibroblasts. The compressive modulus and the biological properties after 3‐day coculture indicate a close resemblance with the native skin. Using the SE, a testing system to study the damage caused by UVA irradiation and evaluate antioxidant efficacy is established. The effectiveness of Tea polyphenols (TPs) and L‐ascorbic acid (Laa) is compared based on free radical generation. TPs are demonstrated to be more effective in downregulating free radical generation. Further, T1 relaxometry is used to detect the generation of free radicals at a single‐cell level, which allows tracking of the same cell before and after UVA treatment.

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Quantum Sensing Unravels Antioxidant Efficacy Within PCL/Matrigel Skin Equivalents

Wu,

Koch,

Martínez

et al. 2024

Small

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On the need for standardized reporting of photophysical parameters of in vitro photodynamic therapy studies

Dick

Jamal

Liu

et al. 2023

Photodiagnosis and Photodynamic Therapy

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Plant-Derived Metal Nanoparticles (PDMNPs): Synthesis, Characterization, and Oxidative Stress-Mediated Therapeutic Actions

Khan

2023

Future Pharmacology

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In the 21st century, plant-derived metal nanoparticles (PDMNPs) have gained considerable interest because of their tremendous and remarkable potential as therapeutic agents as well as development of less expensive, safer, and easier biomedical equipment. PDMNPs are synthesized from metal salts or oxides by using plant extracts because plants have diversified bioactive compounds that can act as reducing and stabilizing agents at the time of nanoparticle synthesis. Besides, PDMNPs take advantages over the nanoparticles synthesized by other methods because of their low cost, environmental friendliness, and sustainability. The present review explains the synthesis of PDMNPs, their characterization techniques, and oxidative stress-mediated pharmacological effects. The mode of actions for antioxidant, antimicrobial, and anticancer properties has also been critically explored. Due to the plethora of data on plant-derived nanoparticles and their pharmacological properties, we have highlighted PDMNPs’ shape, size, metals of use, and experimental findings regarding their antioxidant, anti-microbial, and anticancer properties in a tabulated form for studies conducted in the last five years, from 2018 to 2022. Because of our review study, we, herein, contemplate that the scientific community as a whole will get a greater comprehension of PDMNPs and their numerous therapeutic applications in a single window.

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Non-Enzymatic Natural Reactive Oxygen Scavengers (Ros): A Review on Structures and Mode of Action

Cited by 3 publications

References 24 publications

Quantum Sensing Unravels Antioxidant Efficacy Within PCL/Matrigel Skin Equivalents

Quantum Sensing Unravels Antioxidant Efficacy Within PCL/Matrigel Skin Equivalents

On the need for standardized reporting of photophysical parameters of in vitro photodynamic therapy studies

Plant-Derived Metal Nanoparticles (PDMNPs): Synthesis, Characterization, and Oxidative Stress-Mediated Therapeutic Actions

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