Non-enzymatic sensing of glucose and hydrogen peroxide using a glassy carbon electrode modified with a nanocomposite consisting of nanoporous copper, carbon black and nafion

Mei, Ling; Zhang, Pengcheng; Chen, Jiyun; Chen, Dandan; Quan, Ying; Gu, Ning; Zhang, Genhua; Cui, Rongjing

doi:10.1007/s00604-016-1764-0

Cited by 71 publications

(23 citation statements)

References 32 publications

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“…All these data help to prove the excellent electrochemical behavior of CB nanoparticles, making it an exciting alternative carbon nanomaterial for construction of electrochemical sensors and biosensors. Currently, the use of CB for sensing purposes involves the electrochemical determination of pharmaceutical [4,[34][35][36][38][39][40][41][42][43], environmental contaminants [44][45][46][47][48][49][50][51][52][53][54][55][56][57], food additives [58][59][60][61], biomolecules [46,[62][63][64][65][66][67][68][69][70][71], and nicotine [12].…”

Section: Biosensors Based On Nanostructured Carbon Blackmentioning

confidence: 99%

Electrochemical Biosensors Based on Nanostructured Carbon Black: A Review

Silva

Moraes

Janegitz

et al. 2017

Journal of Nanomaterials

133

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Carbon black (CB) is a nanostructured material widely used in several industrial processes. This nanomaterial features a set of remarkable properties including high surface area, high thermal and electrical conductivity, and very low cost. Several studies have explored the applicability of CB in electrochemical fields. Recent data showed that modified electrodes based on CB present fast charge transfer and high electroactive surface area, comparable to carbon nanotubes and graphene. These characteristics make CB a promising candidate for the design of electrochemical sensors and biosensors. In this review, we highlight recent advances in the use of CB as a template for biosensing. As will be seen, we discuss the main biosensing strategies adopted for enzymatic catalysis for several target analytes, such as glucose, hydrogen peroxide, and environmental contaminants. Recent applications of CB on DNA-based biosensors are also described. Finally, future challenges and trends of CB use in bioanalytical chemistry are discussed.

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Section: Biosensors Based On Nanostructured Carbon Blackmentioning

confidence: 99%

Electrochemical Biosensors Based on Nanostructured Carbon Black: A Review

Silva

Moraes

Janegitz

et al. 2017

Journal of Nanomaterials

133

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“…A good linear relationship can be obtained between the ▵F values and glucose concentrations in the range of 0∼1.5 μM (R=0.9975), as exhibited in Figure b. It can be seen that the fluorescence response produced by as low as 0.2 μM glucose can be clearly discriminated from the blank control, indicating that although the operation is extremely simple, the detection limit of glucose by the proposed assay (110 nM, 3σ, n=11) is lower than many other literature methods ,,,. Furthermore, in order to examine the possibility of the as‐proposed CeO 2 /calcein‐based system for the detection of glucose level in real complex sample, the detection of glucose in the fetal bovine serum (FBS, as a model complex serum sample) commercially purchased from Sigma‐Aldrich was conducted.…”

Section: Resultsmentioning

confidence: 75%

“…Up to now, various kinds of analytical techniques, such as the colorimetric analysis, fluorometry,, electrochemistry, and chemiluminescence,, have been utilized for the detection of H 2 O 2 and glucose. Each of these approaches has their own advantages and greatly advances the sensing of H 2 O 2 and glucose.…”

Section: Introductionmentioning

confidence: 99%

Target-Regulated Ce³⁺ /Ce⁴⁺ Redox Switch for Fluorescence Turn-on Detection of H₂ O₂ and Glucose

2017

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A facile fluorescence turn‐on assay for the sensitive detection of H2O2 and glucose is developed based on the target‐regulated redox state switch between Ce3+ and Ce4+. In this study, Ce3+ can efficiently quench the fluorescence of calcein while Ce4+ will not. Therefore, in the fluorescence‐quenched Ce3+/calcein‐based system, the H2O2‐catalyzed oxidation of Ce3+ to Ce4+ will lead to the fluorescence recovery of calcein, which can be recorded for the quantitation of H2O2. More interestingly, CeO2 nanoparticle, a fascinating material, exposes both Ce3+ and Ce4+ in a redox equilibration state on its surface. The H2O2‐regulated Ce3+/ Ce4+ redox state switch on CeO2 surface will be much easier and faster than that in the solution. Therefore, a CeO2/calcein complex‐based sensing system is further developed, and the detection limit of H2O2 can be pushed down to a low concentration of 8 nM, which is nearly three orders of magnitude lower than that of the Ce3+/calcein‐based sensing mechanism. Furthermore, by using the CeO2/calcein‐based system, glucose can be also sensitively detected with the assistance of glucose oxidase (GOx), and as low as 200 nM glucose can be clearly discriminated from the blank control. This proposed strategy provides a simple, cost‐effective, and highly sensitive approach for detecting H2O2, glucose as well as other oxidases‐related bioreactions, which may serve as a powerful tool for biosensing and clinical diagnostics.

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“…0.01 -0.46 A mM -1 cm -2 [7], [8], fast response (e.g. 1 sec, [9]), and low-cost and high reproducibility ( [10]; [11]). However, when compared to enzymatic sensors, most of the reported sensors suffered from a short linear range (e.g., 0.5 -7.5 mM, [12].…”

Section: Introductionmentioning

confidence: 99%

Performance-Enhanced Non-Enzymatic Glucose Sensor Based on Graphene-Heterostructure

Sakr

Elgammal

Delin

et al. 2019

Preprint

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Non-enzymatic glucose sensing is a crucial field of study because of the current market demand. This study proposes a novel design of glucose sensor with enhanced selectivity and sensitivity by using graphene Schottky diodes, which is composed of Graphene/Platinum Oxide/n-Silicon heterostructure. The sensor was tested with different glucose concentrations and interfering solutions to investigate its sensitivity and selectivity. Different structures of the device were studied by adjusting the platinum oxide film thickness to investigate its catalytic activity. It was found that the film thickness plays a significant role in the efficiency of glucose oxidation and hence in overall device sensitivity. Moreover, theoretical investigations were conducted using Density Function Theory (DFT) to better understand the detection method and the origins of selectivity. The working principle of the sensors puts it in a competitive position with other non-enzymatic glucose sensors. DFT calculations provided a qualitative explanation of the charges distributed across the graphene sheet within a system of a platinum substrate with D-glucose molecules above. The proposed graphene/PtO/n-Si heterostructure has proven to satisfy these factors, which opens the door for further developments of more reliable non-enzymatic glucometers for continuous glucose monitoring systems.

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Non-enzymatic sensing of glucose and hydrogen peroxide using a glassy carbon electrode modified with a nanocomposite consisting of nanoporous copper, carbon black and nafion

Cited by 71 publications

References 32 publications

Electrochemical Biosensors Based on Nanostructured Carbon Black: A Review

Electrochemical Biosensors Based on Nanostructured Carbon Black: A Review

Target-Regulated Ce³⁺ /Ce⁴⁺ Redox Switch for Fluorescence Turn-on Detection of H₂ O₂ and Glucose

Performance-Enhanced Non-Enzymatic Glucose Sensor Based on Graphene-Heterostructure

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Non-enzymatic sensing of glucose and hydrogen peroxide using a glassy carbon electrode modified with a nanocomposite consisting of nanoporous copper, carbon black and nafion

Cited by 71 publications

References 32 publications

Electrochemical Biosensors Based on Nanostructured Carbon Black: A Review

Electrochemical Biosensors Based on Nanostructured Carbon Black: A Review

Target-Regulated Ce3+ /Ce4+ Redox Switch for Fluorescence Turn-on Detection of H2 O2 and Glucose

Performance-Enhanced Non-Enzymatic Glucose Sensor Based on Graphene-Heterostructure

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Target-Regulated Ce³⁺ /Ce⁴⁺ Redox Switch for Fluorescence Turn-on Detection of H₂ O₂ and Glucose