Estimating global fluxes of precious metals is key to understanding early monetary systems. This work adds silver (Ag) to the metals (Pb and Cu) used so far to trace the provenance of coinage through variations in isotopic abundances. Silver, copper, and lead isotopes were measured in 91 coins from the East Mediterranean Antiquity and Roman world, medieval western Europe, 16th-18th century Spain, Mexico, and the Andes and show a great potential for provenance studies. Pre-1492 European silver can be distinguished from Mexican and Andean metal. European silver dominated Spanish coinage until Philip III, but had, 80 y later after the reign of Philip V, been flushed from the monetary mass and replaced by Mexican silver.A particularly momentous time during the early history of modern European economy was the attempt by Hamilton (1) to demonstrate that the great Price Revolution (1520-1650) was largely fueled by the influx of American silver rather than by widespread coinage debasement and minting of the lowdenomination copper "vellón". The idea connecting silver influx to European inflation was actually proposed as far back as the16th century by the French philosopher Jean Bodin (2) and is commonplace in classical economics. Huge amounts of silver, ∼300 t annually (3-5), were mined in the Spanish Americas from the 16th to the 18th centuries. That much silver could not be absorbed locally by the American economy and therefore headed for the European market through major Spanish harbors (6), notably Seville (7), and to the Far East either directly through the Philippines or indirectly through Europe (8). The thesis that the Price Revolution in Spain was fueled by the influx of American silver has, however, become controversial in recent literature (9-11). More specifically, some authors emphasized that the arrival of American metals (ca. 1550 to ca. 1809) does not coincide with the period of inflation (ca. 1520 to ca. 1650) (9-11). Understanding silver monetary mass and circulation relies on three types of primary data: (i) the register of taxes collected when the silver bars received the royal stamp (the Quinto in Peru and the Diezmo in Mexico) (12, 13), (ii) the register of the European harbors used to import the silver shippings (1), and (iii) the compilation of contemporaneous gazettes (9). These data are imprecise or even incomplete, especially for trade registers between 1660 and 1809 (9), and do not take contraband and piracy silver into account (8,(14)(15)(16)(17). In addition, any memory of the origin of the metal is lost by recoinage, whenever silver is exported or a new king comes to power, or upon debasement. Reliable tracers of the monetary mass and exchange that can see through the destructive alterations of coinage silver therefore are needed. Over the last 30 years, lead isotope compositions of metallic ores have been collected and gathered into large databases and broadly used as a tool for provenance studies of archaeological artifacts (18)(19)(20). The main factors of provenance analysis are (i) the...