Non-inferiority study of the efficacy of two hyaluronic acid products in post-extraction sockets of impacted third molars

Yang, Han-Chul; Kim, Jung-Hun; Kim, Jihong; Kim, Dong-Wook; Kim, Hyung Jun

doi:10.1186/s40902-020-00287-y

Cited by 3 publications

(4 citation statements)

References 13 publications

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“…In all preclinical trials, HyA was applied into the tooth socket after extraction of regularly erupted teeth [ 30 – 34 ]. The clinical trials were divided into 3 groups according to treatment indication: (1) surgical removal of LM3 (RCT ( n = 10), CT ( n = 1)) [ 35 – 45 ], (2) extraction of regularly erupted teeth (RCT ( n = 7), non-randomized split-mouth study ( n = 1), prospective case series ( n = 1)) [ 46 – 54 ], and (3) treatment of AO (RCT ( n = 1), prospective case series ( n = 1)) [ 55 , 56 ].…”

Section: Resultsmentioning

confidence: 99%

“…In one clinical study, a multicenter study design was reported including 8 medical centers [ 56 ], whereas all other clinical studies were performed in a single department in a university setting. Eleven clinical studies did not report on funding sources, while in 9 clinical studies [ 35 , 36 , 42 , 44 , 45 , 52 , 53 , 56 , 60 ] the funding was provided by the department; however, in 3 out of these 9 studies, the HyA gel was provided by the manufacturer [ 46 , 52 , 53 ]. In a single study, the funding was provided by 3 different research foundations [ 48 ].…”

Section: Resultsmentioning

confidence: 99%

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Hyaluronic acid in tooth extraction: a systematic review and meta-analysis of preclinical and clinical trials

Domic,

Bertl,

Lang

et al. 2023

Clin Oral Invest

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Objectives To assess whether in animals or patients with ≥ 1 tooth extracted, hyaluronic acid (HyA) application results in superior healing and/or improved complication management compared to any other treatment or no treatment. Materials and methods Three databases were searched until April 2022. The most relevant eligibility criteria were (1) local application of HyA as adjunct to tooth extraction or as treatment of alveolar osteitis, and (2) reporting of clinical, radiographic, histological, or patient-reported data. New bone formation and/or quality were considered main outcome parameters in preclinical studies, while pain, swelling, and trismus were defined as main outcome parameters in clinical studies. Results Five preclinical and 22 clinical studies (1062 patients at final evaluation) were included. In preclinical trials, HyA was applied into the extraction socket. Although a positive effect of HyA was seen in all individual studies on bone formation, this effect was not confirmed by meta-analysis. In clinical studies, HyA was applied into the extraction socket or used as spray or mouthwash. HyA application after non-surgical extraction of normally erupted teeth may have a positive effect on soft tissue healing. Based on meta-analyses, HyA application after surgical removal of lower third molars (LM3) resulted in significant reduction in pain perception 7 days postoperatively compared to either no additional wound manipulation or the application of a placebo/carrier. Early post-operative pain, trismus, and extent of swelling were unaffected. Conclusions HyA application may have a positive effect in pain reduction after LM3 removal, but not after extraction of normally erupted teeth. Clinical relevance HyA application may have a positive effect in pain reduction after surgical LM3 removal, but it does not seem to have any impact on other complications or after extraction of normally erupted teeth. Furthermore, it seems not to reduce post-extraction alveolar ridge modeling, even though preclinical studies show enhanced bone formation.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Hyaluronic acid in tooth extraction: a systematic review and meta-analysis of preclinical and clinical trials

Domic,

Bertl,

Lang

et al. 2023

Clin Oral Invest

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“…In addition, sodium hyaluronate can also strengthen the bond between fibrin and collagen so that blood clots become more stable and less easily damaged. 18 The wound healing process of the extraction socket can also be assessed clinically by the size of the socket wound. The faster the size of the wound decreases, the faster the wound healing process takes place.…”

Section: Discussionmentioning

confidence: 99%

The effect of an 8% cocoa bean extract gel on the healing of alveolar osteitis following tooth extraction in Wistar rats

et al. 2022

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Background: Alveolar osteitis is a well-known complication that occurs following a tooth extraction when the clot within the socket breaks down too early, causing increased localised inflammation and extreme pain. Alveolar osteitis delays the wound healing process of the socket. The polyphenols in the cocoa bean (Theobroma cacao L.) can stimulate the wound healing process. Purpose: The aim of this study was to analyse the effect of an 8% cocoa bean extract gel on the healing of alveolar osteitis following a tooth extraction. Methods: This study is an in vivo experiment with a posttest-only control group design. Thirty-six male Wistar rats were divided into three groups: a negative control, positive control and an 8% cocoa bean extract gel. A tooth extraction was performed on the mandibular incisor, and alveolar osteitis was induced by the application of adrenaline using a paper point on the socket. On the 3rd, 7th and 14th days, the clinical wound size of the extraction socket was measured, and the rats were sacrificed to observe the number of macrophages, fibroblasts and osteoblasts microscopically. A two-way analysis of variance test and post hoc least significant difference test were used to analyse the data (p < 0.05). Results: The data analysis showed a significant difference in the clinical wound size of the extraction socket and the number of macrophages, fibroblasts and osteoblasts between the 8% cocoa bean extract gel and the control groups (p = 0.000). Conclusion: An 8% cocoa bean extract gel stimulates the healing of alveolar osteitis following tooth extraction in Wistar rats.

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“…A mouthwash with hyaluronic acid and cetylpyridinium chloride was shown to be as effective as a chlorhexidine mouthwash in reducing plaque accumulation [ 83 ]. Furthermore, hyaluronic-acid-containing formulations reduced complications after tooth extractions [ 84 , 85 ]. However, Zorrilla et al showed that the use of a chlorhexidine-chitosan gel resulted in better healing than with the use of a hyaluronic acid gel after oral surgery [ 86 ].…”

Section: Overview On Adjunct Ingredients Used In Hydroxyapatite-based...mentioning

confidence: 99%

Overview on Adjunct Ingredients Used in Hydroxyapatite-Based Oral Care Products

2022

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Hydroxyapatite, Ca5(PO4)3(OH), is a biomimetic active ingredient, which is used in commercial oral care products such as toothpastes and mouthwashes worldwide. Clinical studies (in vivo) as well as in situ and in vitro studies have shown the preventive effects of hydroxyapatite in various field of oral care. In some products, hydroxyapatite is combined with other active ingredients, to achieve an additional antibacterial effect or to promote gum health. This review analyzes the efficacy of six selected natural and nature-inspired ingredients that are commonly used together with hydroxyapatite. These additional actives are either antibacterial (lactoferrin, xylitol, and zinc) or promote gum health (allantoin, bisabolol, and hyaluronic acid). A systematic literature search was performed, and all studies found on each ingredient were analyzed. In summary, all analyzed ingredients mentioned in this review are well described in scientific studies on their beneficial effect for oral health and can be used to expand the preventive effect of hydroxyapatite in oral care products.

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Non-inferiority study of the efficacy of two hyaluronic acid products in post-extraction sockets of impacted third molars

Cited by 3 publications

References 13 publications

Hyaluronic acid in tooth extraction: a systematic review and meta-analysis of preclinical and clinical trials

Hyaluronic acid in tooth extraction: a systematic review and meta-analysis of preclinical and clinical trials

The effect of an 8% cocoa bean extract gel on the healing of alveolar osteitis following tooth extraction in Wistar rats

Overview on Adjunct Ingredients Used in Hydroxyapatite-Based Oral Care Products

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