Non-intercepted dose errors in prescribing anti-neoplastic treatment: a prospective, comparative cohort study

Mattsson, Thea Otto; Holm, Bente; Michelsen, Hanne Marie; Knudsen, Jeanne L; Brixen, Kim; Herrstedt, Jørn

doi:10.1093/annonc/mdv032

Cited by 27 publications

(34 citation statements)

References 19 publications

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“…For that purpose, we compared two groups, with and without PIs, during the same period. Gender and age were not significantly different from one group to another, as opposed to what was described by Mattsson et al., who found that prescriptions for men had fewer errors than those for women . The authors explained this result by the difference between disease in men and women and the related drugs used in each case.…”

Section: Discussioncontrasting

confidence: 57%

“…Finally in two hospitals, Mattsson et al. estimated that 1.7% of anticancer drug prescriptions were erroneously administered without being intercepted …”

Section: Discussionmentioning

confidence: 99%

“…Prescriptions were identified as standardized or nonstandardized protocols as previously described. Gender was investigated as a risk factor because a recent study reported that demonstrated female gender was significantly associated with prescription error . For age, we hypothesized that less than 1 year of age, children's weight is usually less than 10 kg and modification of dose calculation from mg/kg to mg/m² can be associated with prescription error.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Computerized pediatric oncology prescriptions review by pharmacist: A descriptive analysis and associated risk factors

Hamel

Tortolano

Bermudez

et al. 2017

Pediatric Blood & Cancer

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Not surprisingly, PIs were predominantly to correct dose errors, half of which related to height and weight measurements that were not updated. No significant risk factors for errors were identified for errors except in the standardized status of prescription, which appears to be linked in part to our software that did not automatically reflect dose reduction from one course to the next. Medical double-checking followed by a clinical pharmacist's double check were effective in order to prevent prescription errors.

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Section: Discussioncontrasting

confidence: 57%

“…Finally in two hospitals, Mattsson et al. estimated that 1.7% of anticancer drug prescriptions were erroneously administered without being intercepted …”

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Computerized pediatric oncology prescriptions review by pharmacist: A descriptive analysis and associated risk factors

Hamel

Tortolano

Bermudez

et al. 2017

Pediatric Blood & Cancer

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“…Previous literature regarding error reduction through novel technology highlighted that the use of CPOE may introduce new types of errors . The first CPOE system used at FUMC was implemented in 2006.…”

Section: Discussionmentioning

confidence: 99%

“…Previous literature regarding error reduction through novel technology highlighted that the use of CPOE may introduce new types of errors. 10,26 The first CPOE system used at FUMC was implemented in 2006. The new-generation ordering tool is developed from the previously used software and thus benefits from the longterm experience of its application in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

Avoiding chemotherapy prescribing errors: Analysis and innovative strategies

Reinhardt

Otte

Eggleton

et al. 2019

Cancer

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Background At Freiburg University Medical Center, chemotherapy prescriptions are processed via a computerized physician order entry (CPOE) tool and clinically checked by a designated chemotherapy surveillance team. Any error detected is reported instantly, corrected, and prospectively recorded. The objective of the current study was to gain insight into the causes, potential consequences, and future preventability of chemotherapy prescribing errors. Methods A detailed analysis of 18,823 consecutive antineoplastic orders placed in 2013 through 2014 was performed. In cooperation with information technology (IT) specialists, the intercepted errors were analyzed for effective future prevention using IT measures. Potential error consequences were determined by case discussions between pharmacists and physicians. Results Within 24 months, a total of 406 chemotherapy prescribing errors were intercepted that affected 375 (2%) of the total orders. Errors were classified as clinically relevant in 279 of the chemotherapy orders (1.5%). In these cases, reduced therapeutic efficacy (0.44%), the need for increased monitoring (0.48%), prolonged hospital stay (0.55%), and fatality (0.02%) were avoided as potential consequences. The most efficient conventional measures for error prevention comprised checking the order history and patient’s medical record, and a detailed knowledge of chemotherapy protocols. Of all the errors analyzed, 61% would be avoided through further software development. The improvements identified are implemented through a validated next‐generation CPOE tool. Conclusions The upgraded CPOE tool can be shared across other hospitals to raise safety standards and spread potential benefits across a wider patient population. The current analysis also highlighted that approximately 30% to 40% of errors cannot be avoided electronically. Therefore, pharmacovigilance initiatives remain indispensable.

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Impact of computerised physician order entry (CPOE) on the incidence of chemotherapy-related medication errors: a systematic review

Srinivasamurthy

Ashokkumar

Kodidela

et al. 2021

Eur J Clin Pharmacol

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Purpose Computerised prescriber (or physician) order entry (CPOE) implementation is one of the strategies to reduce medication errors. The extent to which CPOE influences the incidence of chemotherapy-related medication errors (CMEs) was not previously collated and systematically reviewed. Hence, this study was designed to collect, collate, and systematically review studies to evaluate the effect of CPOE on the incidence of CMEs. Methods A search was performed of four databases from 1 January 1995 until 1 August 2019. English-language studies evaluating the effect of CPOE on CMEs were selected as per inclusion and exclusion criteria. The total CMEs normalised to total prescriptions pre- and post-CPOE were extracted and collated to perform a meta-analysis using the ‘meta’ package in R. The systematic review was registered with PROSPERO CRD42018104220. Results The database search identified 1621 studies. After screening, 19 studies were selected for full-text review, of which 11 studies fulfilled the selection criteria. The meta-analysis of eight studies with a random effects model showed a risk ratio of 0.19 (95% confidence interval: 0.08–0.44) favouring CPOE (I2 = 99%). Conclusion The studies have shown consistent reduction in CMEs after CPOE implementation, except one study that showed an increase in CMEs. The random effects model in the meta-analysis of eight studies showed that CPOE implementation reduced CMEs by 81%.

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Non-intercepted dose errors in prescribing anti-neoplastic treatment: a prospective, comparative cohort study

Cited by 27 publications

References 19 publications

Computerized pediatric oncology prescriptions review by pharmacist: A descriptive analysis and associated risk factors

Computerized pediatric oncology prescriptions review by pharmacist: A descriptive analysis and associated risk factors

Avoiding chemotherapy prescribing errors: Analysis and innovative strategies

Impact of computerised physician order entry (CPOE) on the incidence of chemotherapy-related medication errors: a systematic review

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