Non-invasive assessment of liver fibrosis in patients with alcoholic liver disease using acoustic radiation force impulse elastography

Zhang, Dakun; Chen, Min; Liu, Liping; Liu, Yang; Zhao, Yuanyuan; Wang, Ruifang

doi:10.1007/s00261-014-0154-5

Cited by 43 publications

(26 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Point SWE has proven diagnostic assessment in liver fibrosis in patients with chronic viral hepatitis B and C, alcoholic and non-alcoholic steatohepatitis [18][19][20][21]. Also, the ARFI technique is used in the assessment of liver fibrosis, in the pathology of the thyroid, breast, prostate, and lymph nodes [9,[22][23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

The pursuit of normal reference values of pancreas stiffness by using Acoustic Radiation Force Impulse (ARFI) elastography.

et al. 2016

View full text Add to dashboard Cite

Aim: The purpose of this study is to evaluate pancreatic stiffness by ARFI abdominal elastography. In the current literature, there are relatively few studies that have assessed the clinical utility of this technique. Material and method: A number of 37 healthy subjects were included. The data were collected in a prospective manner and afterwards included in an observational, analytical and longitudinal study. Subsequently viewing the pancreatic parenchyma in bidimensional mode (2D-US) mode, 10 shear wave velocity (SWV) measurements for each segment: head, body and tail were performed. Statistical analysis by regression models targeted also the possible influence of other factors in assessing SWV. A comparative analysis was performed regarding the statistical significance of 5 versus 10 SWV measurements for each segment. Results: The pancreas was entirely evaluated in all subjects. The mean SWV from the entire parenchyma was 1.216 m/s±0.36 and between the three segments SWV were similar (head: 1.224 m/s, body: 1.227 m/s and tail: 1.191 m/s). A ratio of the IQR/Median >0.4 was interpreted as statistically invalid, relevant data being highlighted in the percentage of 83.78% for the head of the pancreas, 78.37% for the body, and 67.56% at the caudal level. Significant correlations were observed between the data (mean and median SWV) provided by the group with 5 measurements of the SWV versus the standard group: 93.9% for the head, 96.6% for the body, and 98.7% accordingly to the tail. Conclusions: SWV determination by percutaneous approach represents a useful imaging method for evaluating pancreatic stiffness, of course within these limitations. Because we did not observe statistically significant differences between the results obtained by 5 or 10 measurements, we suggest that it would be sufficient to perform only five measurements of the SWV per pancreatic segment. The data obtained in the normal pancreas could be used in future comparative assessments regarding the inflammatory or tumoral pathology of the pancreas.

show abstract

Section: Introductionmentioning

confidence: 99%

The pursuit of normal reference values of pancreas stiffness by using Acoustic Radiation Force Impulse (ARFI) elastography.

et al. 2016

View full text Add to dashboard Cite

show abstract

“…These techniques have been employed to assess the mechanical elasticity of various organs of different shapes and sizes. Previous studies showed promising results in evaluating liver fibrosis (Palmeri et al, 2011, Bavu et al, 2011, Nierhoff et al, 2013, Sporea et al, 2013 and Zhang et al, 2014), breast lesions (Meng et al, 2011), vascular plaques (Doherty et al, 2012), prostate cancers (Zhai et al, 2012 and Correas et al, 2013), and muscle anisotropy(Gennisson et al, 2010). Other organs where ARFI and SWEI have been explored include the bladder (Nenadic et al, 2013), cervix (Feltovich et al, 2012), and cornea (Tanter et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Preliminary Results on the Feasibility of Using ARFI/SWEI to Assess Cutaneous Sclerotic Diseases

Lee

Cardones

Doherty

et al. 2015

Ultrasound in Medicine & Biology

View full text Add to dashboard Cite

In this study, Acoustic Radiation Force Impulse (ARFI) and Shear Wave Elasticity Imaging (SWEI) were applied to the skin to investigate the feasibility of their use in assessing sclerotic skin diseases. Our motivation was to develop a non-invasive imaging technology with real-time feedback of sclerotic skin disease diagnosis. This paper shows representative results from an ongoing study recruiting subjects with and without sclerosis. The stiffness of the imaged site was evaluated using two metrics: mean ARFI displacement magnitude and bulk shear wave speed inside the region of interest (ROI). In a subject with localized Graft versus Host Disease (GVHD), the mean ARFI displacement inside sclerotic skin was 61% lower (p<0.01) and shear wave speed 128% higher (p<0.005) compared to those in normal skin— indicating stiffer mechanical properties in the sclerotic skin. This trend persisted through disease types. We conclude ARFI and SWEI can successfully differentiate sclerotic lesions from normal dermis.

show abstract

“…Zhang et al [90] showed a strong correlation (r = 0.685, p < 0.001) between histological fibrosis and liver stiffness in patients with ALD, as measured by ARFI elastography. Using the Scheuer scoring system for histologic grading of fibrosis, they found areas under the receiver operating characteristic curve of 0.846 and 0.893 for the differentiation of significant fibrosis ( ‡S2) and cirrhosis (S4), respectively [90].…”

Section: Alcoholic Liver Disease (Ald)mentioning

confidence: 97%

“…Using the Scheuer scoring system for histologic grading of fibrosis, they found areas under the receiver operating characteristic curve of 0.846 and 0.893 for the differentiation of significant fibrosis ( ‡S2) and cirrhosis (S4), respectively [90].…”

Section: Alcoholic Liver Disease (Ald)mentioning

confidence: 99%

Ultrasound elastography: liver

2015

View full text Add to dashboard Cite

Ultrasound elastography, also termed sonoelastography, is being used increasingly in clinical practice to aid the diagnosis and management of diffuse liver disease. Elastography has been shown to be capable of differentiating advanced and early-stage liver fibrosis, and consequently a major application in clinical liver care includes progression to cirrhosis risk stratification through (1) assessment of liver fibrosis stage in HCV and HBV patients, (2) distinguishing non-alcoholic steatohepatitis from simple steatosis in non-alcoholic fatty liver disease patients, and (3) prognostic evaluation of liver disease is autoimmune liver disease. In addition, elastographic characterization of focal liver lesions and evaluation of clinically significant portal hypertension have the potential to be clinically useful and are areas of active clinical research.

show abstract

Non-invasive assessment of liver fibrosis in patients with alcoholic liver disease using acoustic radiation force impulse elastography

Abstract: ARFI elastography is an acceptable method for predicting the severity of fibrosis in patients with ALD. ARFI elastography is influenced by elevated aminotransferase levels in ALD.

Cited by 43 publications

References 27 publications

The pursuit of normal reference values of pancreas stiffness by using Acoustic Radiation Force Impulse (ARFI) elastography.

The pursuit of normal reference values of pancreas stiffness by using Acoustic Radiation Force Impulse (ARFI) elastography.

Preliminary Results on the Feasibility of Using ARFI/SWEI to Assess Cutaneous Sclerotic Diseases

Ultrasound elastography: liver

Contact Info

Product

Resources

About