Non-invasive optical imaging of cathepsin B with activatable fluorogenic nanoprobes in various metastatic models

Ryu, Jee Hoon; Na, Jin Hee; Ko, Ho Kyung; You, Dong Gil; Park, Subin; Jun, Eunsung; Yeom, Ho Jun; Seo, Deok Ho; Park, Jae Hyung; Jeong, Seo Young; Kim, In San; Kim, Byung Soo; Kwon, Ick Chan; Choi, Kuiwon; Kim, Kwangmeyung

doi:10.1016/j.biomaterials.2013.11.080

Cited by 50 publications

(27 citation statements)

References 34 publications

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“…For example, the use of another peptide sequence4849, NH 2 –GGRRGGC–SH instead of H 2 N–GPLGVRGC–SH, as the linker between Acy and AuNRs enables the fabrication of a nanoprobe (Pep 2 -Acy@AuNRs) for specific response to cathepsin B (CtsB), a tumour-specific enzyme overexpressed in various malignant tumours254849, and the specific fluorescence activation of Pep 2 -Acy@AuNRs synergistically governed by CtsB and pH (Supplementary Figs 19–23). Our strategy for the design of theranostic probes with dual-stimuli synergistically and reversibly activatable fluorescence imaging-guided precision photothermal therapy provides a valuable approach to construct smart theranostic platform for clinical applications.…”

Section: Discussionmentioning

confidence: 99%

Dual-stimuli responsive and reversibly activatable theranostic nanoprobe for precision tumor-targeting and fluorescence-guided photothermal therapy

et al. 2017

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The integrated functions of diagnostics and therapeutics make theranostics great potential for personalized medicine. Stimulus-responsive therapy allows spatial control of therapeutic effect only in the site of interest, and offers promising opportunities for imaging-guided precision therapy. However, the imaging strategies in previous stimulus-responsive therapies are ‘always on' or irreversible ‘turn on' modality, resulting in poor signal-to-noise ratios or even ‘false positive' results. Here we show the design of dual-stimuli-responsive and reversibly activatable nanoprobe for precision tumour-targeting and fluorescence-guided photothermal therapy. We fabricate the nanoprobe from asymmetric cyanine and glycosyl-functionalized gold nanorods (AuNRs) with matrix metalloproteinases (MMPs)-specific peptide as a linker to achieve MMPs/pH synergistic and pH reversible activation. The unique activation and glycosyl targetibility makes the nanoprobe bright only in tumour sites with negligible background, while AuNRs and asymmetric cyanine give synergistic photothermal effect. This work paves the way to designing efficient nanoprobes for precision theranostics.

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Section: Discussionmentioning

confidence: 99%

Dual-stimuli responsive and reversibly activatable theranostic nanoprobe for precision tumor-targeting and fluorescence-guided photothermal therapy

et al. 2017

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“…have developed caspase 3-sensitive quantum dot-fluorescent protein nanoparticles[260]. Similarly, cathepsin B-sensitive fluorogenic chitosan nanoparticles have been used to discriminate metastases in vivo in three metastatic mouse models[261]. Also, Ferber et al .…”

Section: Applying Nanomedicine In Inflammation Dynamicsmentioning

confidence: 99%

Applying nanomedicine in maladaptive inflammation and angiogenesis

Alaarg

Pérez-Medina

Metselaar

et al. 2017

Advanced Drug Delivery Reviews

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Inflammation and angiogenesis drive the development and progression of multiple devastating diseases such as atherosclerosis, cancer, rheumatoid arthritis, and inflammatory bowel disease. Though these diseases have very different phenotypic consequences, they possess several common pathophysiological features in which monocyte recruitment, macrophage polarization, and enhanced vascular permeability play critical roles. Thus, developing rational targeting strategies tailored to the different stages of the journey of monocytes, from bone marrow to local lesions, and their extravasation from the vasculature in diseased tissues will advance nanomedicine. The integration of in vivo imaging uniquely allows studying nanoparticle kinetics, accumulation, clearance, and biological activity, at levels ranging from subcellular to an entire organism, and will shed light on the fate of intravenously administered nanomedicines. We anticipate that convergence of nanomedicines, biomedical engineering, and life sciences will help to advance clinically relevant therapeutics and diagnostic agents for patients with chronic inflammatory diseases.

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“…For instance, cathepsin B (CaB) is a lysosomal cysteine protease that was involved in the cancer progression with specific peptide cleaving capability. 52 Thus, it offers an attractive choice for triggering selective cancer therapy. Tian et al 53 designed a CaB-activatable theranostic nanosystem for background-free cancer imaging and selective therapy.…”

Section: Enzyme-responsive Systemsmentioning

confidence: 99%

Endogenous Stimuli-responsive Nanocarriers for Drug Delivery

2016

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Huachao Chen received her M.Sc. degree in chemistry from Shandong Normal University in 2011. After receiving her Ph.D. degree from the Nanjing University in 2015, she is now a lecturer at the China Pharmaceutical University. Her research interests include the multifunctional "stimulus-responsive" drug delivery system, antitumor plant cyclopeptides, and fluorescent imaging of bioactive substance.Danyang Liu received her B.S. degree in chemistry from Nanjing University in 2015. Then she joined Prof. Guo's group at Nanjing University to pursue her M.Sc. degree in bioinorganic chemistry. Her recent research focus on nanoparticle-based antitumor drug delivery. CL-151176Received AbstractDrug release in a spatially and temporally controlled manner is highly desired in the field of drug delivery. Endogenous stimuliresponsive nanocarriers provide significant advantages in maximizing the therapeutic efficacy and minimizing the side effects of loaded drugs. Biomarker-triggered release and site-specific delivery are the most commonly adopted strategies. In this review, the most recent advances in the field of endogenous stimuli-responsive drug delivery nanocarriers and their potential application in the treatment of various diseases are highlighted and discussed.

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Non-invasive optical imaging of cathepsin B with activatable fluorogenic nanoprobes in various metastatic models

Cited by 50 publications

References 34 publications

Dual-stimuli responsive and reversibly activatable theranostic nanoprobe for precision tumor-targeting and fluorescence-guided photothermal therapy

Dual-stimuli responsive and reversibly activatable theranostic nanoprobe for precision tumor-targeting and fluorescence-guided photothermal therapy

Applying nanomedicine in maladaptive inflammation and angiogenesis

Endogenous Stimuli-responsive Nanocarriers for Drug Delivery

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