Non‐invasive tests for fibrosis and liver stiffness predict 5‐year survival of patients chronically infected with hepatitis B virus

Lédinghen, Victor de; Vergniol, Julien; Barthe, Christine; Foucher, Juliette; Chermak, Faïza; Bail, Brigitte Le; Merrouche, Wassil; Bernard, Pierre–Henri

doi:10.1111/apt.12307

Cited by 97 publications

(77 citation statements)

References 45 publications

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“…[33] TE (part of a score) ---0.83-0.89 Elastography to predict the liver related death of the patients with liver cirrhosis Rate of death Pang et al [38] TE 40 kPa 34%/3 yr de Lédinghen et al [39] TE < 9 kPa 2.9%/5 yr > 20 kPa 38.5%/5 yr TE: Transient elastography (fibroscan); ARFI: Acoustic radiation force impulse imaging.…”

Section: Resultsmentioning

confidence: 99%

“…It has been shown by many studies that measuring liver elasticity one can predict the survival of a patient [37][38][39][40] . In the study conducted by Wong et al [37] , they found age, Hui index and liver stiffness to be independent predictors of hepatic event -free survival.…”

Section: Liver Elastography In the Prediction Of The Survival Of The mentioning

confidence: 99%

“…de Lédinghen et al [39] showed that survival in patients with chronic B hepatitis was significantly decreased in patients diagnosed with severe fibrosis, no matter if liver elastography was used (P < 0.0001) or liver biopsy (P = 0.02) for the staging of fibrosis. The study conducted by Vergniol et al [40] also showed that in patients with chronic C hepatitis, noninvasive tests for liver fibrosis (measurement of liver stiffness or FibroTest) can predict 5-year survival.…”

Section: Liver Elastography In the Prediction Of The Survival Of The mentioning

confidence: 99%

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Liver ultrasound elastography: More than staging the disease

Gherlan¹

2015

WJH

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Ultrasound elastography is perhaps the most important breakthrough in the evolution of ultrasonography in the last 15 years. Since transient elastography was introduced, many other methods have been developed and became more and more widely available. The value of ultrasound elastography in staging a chronic liver disease has been established by numerous studies. There have been many studies that have shown that using liver elastography it is possible to predict the presence of the complications of cirrhosis: portal hypertension, presence of esophageal varices (and even their risk of bleeding) and hepatocellular carcinoma. It has been shown that liver elastography can predict the progression of liver fibrosis and also the survival (hepatic events -free) of the patients with chronic liver diseases. These are the real quests of the clinicians, this is the ultimate scope of any medical investigationto predict the outcome of a patient and to help making therapeutic decisions. I brought together only a small amount of the data that has already been written on this subject to support my affirmation that liver ultrasound elastography is more than a tool for staging the liver disease, but it is also comparable to a crystal ball which in the hands of a skilled clinician can reveal the future of the patient and can help to improve this future.

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Section: Resultsmentioning

confidence: 99%

Section: Liver Elastography In the Prediction Of The Survival Of The mentioning

confidence: 99%

Section: Liver Elastography In the Prediction Of The Survival Of The mentioning

confidence: 99%

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Liver ultrasound elastography: More than staging the disease

Gherlan¹

2015

WJH

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“…In recent years, a number of noninvasive tests of liver fibrosis have been developed and validated against liver histology [33,34]. They are noninferior to liver histology in predicting future HCC development and mortality [35,36]. As a result, current European and Latin American guidelines endorse the use of transient elastography and serum tests as initial assessment of liver fibrosis in patients with chronic hepatitis B [37].…”

Section: Hbeag: a Test Through Historymentioning

confidence: 99%

Virus and Host Testing to Manage Chronic Hepatitis B

Wong

Chan

2016

Clin Infect Dis.

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Chronic hepatitis B virus (HBV) infection is a major cause of cirrhosis and hepatocellular carcinoma worldwide. The past 50 years have seen rapid developments in HBV testing. Beginning from traditional serologic tests, the availability of sensitive HBV DNA assays allows a thorough understanding of the virology and natural history of chronic HBV infection. Quantification of hepatitis B surface antigen levels reflects the amount and transcriptional activities of covalently closed circular DNA in the liver and may be used to evaluate the stage of disease and guide antiviral therapy. The natural history of chronic HBV infection is also a manifestation of the interaction between the host and the virus, and recent genomic works have shed light on the host-virus relationship and may provide novel tests in the future. This review highlights recent advances in the application of HBV tests in the management of chronic hepatitis B.

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“…A limitation of all the studies performed thus far is that the reference shear wave TE values for each fibrosis stage were calculated from their own cohort of patients after data collection, and these differ across studies (Shaheen et al, 2007;de Ledinghen and Vergniol, 2008;Stebbing et al, 2010;Tsochatzis et al, 2011). The studies mainly focused on chronic hepatitis C/B, with special emphasis on chronic hepatitis C patients (Ziol et al, 2005;Rigamonti et al, 2008;Lemoine et al, 2008;Chen et al, 2012;de Lédinghen et al, 2013;Feier et al, 2013;Calvaruso et al, 2013). The shear wave values of 7, 9.5, and 12 kPa corresponding to stages F2, F3, and F4, respectively, were used.…”

Section: Introductionmentioning

confidence: 99%

Relationships between transient elastography values and liver fibrosis in chronic liver disease patients with normal or mildly abnormal aminotransferase levels

Zhao

et al. 2015

Genet. Mol. Res.

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ABSTRACT. This study aimed to evaluate relationships between transient elastography values and liver fibrosis in chronic liver disease patients with normal or mildly abnormal aminotransferase levels. Fiftysix patients were enrolled in the study. Transient elastography and liver biopsy were performed on the same day, and the fibrosis was staged based on the Scheuer scoring system. Liver stiffness was measured to assessed liver fibrosis using transient elastography. The transient elastography values of 12 patients with chronic hepatitis B were studied before and 6 months after antiviral treatment. The sensitivity and specificity for 10.88 kPa in S3 were 80 and 87.8%, and for 19.4 kPa in S4, were 100 and 90.7%, respectively. In univariate analysis, liver stiffness strongly correlated with the fibrosis stage (r = 0.70, P < 0.5), moderately correlated with the aminotransferases (r = 0.398, P < 0.05), 18173Transient elastography values and liver fibrosis ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 18172-18180 (2015) and poorly correlated with the degree of necroinflammatory activity (r = 0.19, P < 0.5). In multivariate regression, liver stiffness correlated only with the fibrosis stage (P < 0.05). Pre-and post-treatment viral loads were not significantly different [(4.81 ± 0.15) x 10 6 vs (7.62 ± 0. 16) x 10 3 , P > 0.05]. Pre-and post-treatment LS measurements were not correlated with viral load (P > 0.05). Pre-and post-treatment LS measurements were not significantly different (P > 0.02). In conclusion, transient elastography values correlated with the stage of cirrhosis, alanine aminotransferase levels, and antiviral treatment in patients with chronic hepatitis B and did not correlate with viral loads.

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Non‐invasive tests for fibrosis and liver stiffness predict 5‐year survival of patients chronically infected with hepatitis B virus

Abstract: SUMMARY BackgroundLiver stiffness and non-invasive tests predict overall survival in chronic hepatitis C. However, in patients chronically infected with hepatitis B virus (HBV), only the association between liver stiffness and the risk of hepatocellular carcinoma has been published.

Cited by 97 publications

References 45 publications

Liver ultrasound elastography: More than staging the disease

Liver ultrasound elastography: More than staging the disease

Virus and Host Testing to Manage Chronic Hepatitis B

Relationships between transient elastography values and liver fibrosis in chronic liver disease patients with normal or mildly abnormal aminotransferase levels

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