Non-ionic surfactants and gastric mucosal transport of paraquat

Walters, K.; Dugard, Paul H.; Florence, Alexander T.

doi:10.1111/j.2042-7158.1981.tb13759.x

Cited by 50 publications

(15 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…First, it was assumed that all the oil (soybean oil) and all the surfactant (C 18:1 E 10 ) were occupied in monodisperse, spherical microemulsion droplets, and that the external phase consisted only of water. This is a reasonable assumption because of the low water solubility of the triglyceride oil and low critical micelle concentration (0.006% w/w) of the surfactant C 18:1 E 10 in water 28. Furthermore, because soybean oil is a large molecular volume oil, its incorporation into the C 18:1 E 10 aggregates is thought to promote the transition of nonspherical to spherical aggregates 29.…”

Section: Methodsmentioning

confidence: 99%

Light‐Scattering Studies of Testosterone Enanthate Containing Soybean Oil/C18:1E10/Water Oil‐in‐Water Microemulsions

Malcolmson

Barlow

Lawrence

2002

Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

Section: Methodsmentioning

confidence: 99%

Light‐Scattering Studies of Testosterone Enanthate Containing Soybean Oil/C18:1E10/Water Oil‐in‐Water Microemulsions

Malcolmson

Barlow

Lawrence

2002

Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

“…The results may also indicate that Tween retards 8Brguo uptake by presenting it as suspension, which should be important to the bioactivity of the nucleoside, which has a short halflife in vivo [11,14]. In addition, it has been shown that surfactant molecules are able to penetrate tissue barriers, increasing the permeability of drugs [16,17].…”

Section: Discussionmentioning

confidence: 95%

Efficacy of 8-Bromoguanosine against Murine Cutaneous Leishmaniasis Induced with <i>Leishmania amazonensis</i>

Barão

Giorgio²

2003

Chemotherapy

View full text Add to dashboard Cite

Background and Methods: In this study, we investigated the effect of 8-bromoguanosine (8Brguo), an immunostimulatory compound, in a murine model of experimental cutaneous leishmaniasis. Results: The results indicated that treatment by intraperitoneal administration of 8Brguo (150 mg/kg once daily for 1 week and thereafter once weekly for 1 month) diluted in Tween-80 produces an effect similar to that of treatment with the classical antimonial drug, Glucantime, in Leishmania amazonensis-infected CBA/J mice. While complete cure did not occur, animals treated with the nucleoside had small lesions in the infected footpad and delayed surface ulceration. Studies involving examination of serum glutamic pyruvic transaminase activity, concentration of urea, blood pathology and histology of the spleen, kidney and liver showed no apparent toxicity of the nucleoside in treated mice. Conclusion: The protective in vivo effect during murine leishmaniasis as well as the lack of apparent toxicity of 8Brguo as attested by blood/serum pathology and histology from treated mice encourage further studies of C8-substituted guanine ribonucleosides, such as 8Brguo, as new leishmanial drugs and as modifiers of the immunological response to combat infections with intracellular pathogens.

show abstract

“…The lower HLB surfactants tested are also those with the shortest hydrophilic chains, and so the smallest molecular areas (10).…”

Section: Surfactant Lipophilicitymentioning

confidence: 99%

Interactions of Nonionic Polyoxyethylene Alkyl and Aryl Ethers with Membranes and Other Biological Systems

Florence

Tucker²,

Walters³

1984

ACS Symposium Series

View full text Add to dashboard Cite

Many nonionic surfactants of the poly(oxyethylene) alkyl and aryl ether class interact with biological membranes increasing their permeability and causing increased trans-membrane solute transport. The mechanisms of such effects are not fully understood. Studies of the interaction of homologous series of nonionic surfactants (varying either in hydrophobic or hydrophilic chain length) with a variety of biological substrates, reviewed here, indicate there to be an optimal lipophilicity for maximal membrane activity. Problems with the hydrophile-lipophile balance (HLB) as an index of lipophilicity result from the structural non-specificity of this value. The biological effects of surfactants are concentration dependent and structure dependent. In many cases C12 hydrocarbon chain compounds appear to exert maximal effects and in all series a parabolic relationship between membrane activity and lipophilicity is observed. The effects are complex resulting from penetration of the membrane, its fluidization and, at high surfactant concentrations, solubilization of structural components.Many formulated food and pharmaceutical products contain nonionic surfactants as emulsifiers, suspending, wetting or solubilizing agents ( _1 ). As nonionic surface active agents may have intrinsic biological activity or may influence the bioligical activity of other molecules the optimisation of formulations cannot be carried out without consideration of the biological 1

show abstract

Non-ionic surfactants and gastric mucosal transport of paraquat

Cited by 50 publications

References 20 publications

Light‐Scattering Studies of Testosterone Enanthate Containing Soybean Oil/C18:1E10/Water Oil‐in‐Water Microemulsions

Light‐Scattering Studies of Testosterone Enanthate Containing Soybean Oil/C18:1E10/Water Oil‐in‐Water Microemulsions

Efficacy of 8-Bromoguanosine against Murine Cutaneous Leishmaniasis Induced with <i>Leishmania amazonensis</i>

Interactions of Nonionic Polyoxyethylene Alkyl and Aryl Ethers with Membranes and Other Biological Systems

Contact Info

Product

Resources

About