Non-PDT Uses of lasers in oncology

Brunetaud, J. M.; Mordon, Serge; Maunoury, V.; Beacco, Claire

doi:10.1007/bf02133156

Cited by 22 publications

(19 citation statements)

References 15 publications

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“…Photothermal therapy [49,[57][58][59]] is a minimally-invasive treatment method in which photon energy is converted to thermal energy sufficient to induce cellular hyperthermia. Selectivity is achieved by focused directional control or invasive [40][41][42] (fiber optic) positioning of the incident radiation, often pulsed [28][29][30] or continuous wave [24-28, 30, 48] (cw) laser, and is typically accompanied by preferential administration of photoactive molecules [60][61][62] or nano-scale particles.…”

Section: Introductionmentioning

confidence: 99%

Gold nanorod assisted near-infrared plasmonic photothermal therapy (PPTT) of squamous cell carcinoma in mice

et al. 2008

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Plasmonic photothermal therapy (PPTT) is a minimally-invasive oncological treatment strategy in which photon energy is selectively administered and converted into heat sufficient to induce cellular hyperthermia. The present work demonstrates the feasibility of in vivo PPTT treatment of deep-tissue malignancies using easily-prepared plasmonic gold nanorods and a small, portable, inexpensive near-infrared (NIR) laser. Dramatic size decreases in squamous cell carcinoma xenografts were observed for direct (P<0.0001) and intravenous (P<0.0008) administration of pegylated gold nanorods in nu/nu mice. Inhibition of average tumor growth for both delivery methods was observed over a 13-day period, with resorption of >57% of the directly-injected tumors and 25% of the intravenously-treated tumors.

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Section: Introductionmentioning

confidence: 99%

Gold nanorod assisted near-infrared plasmonic photothermal therapy (PPTT) of squamous cell carcinoma in mice

et al. 2008

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“…The use of lasers in tumor therapy is due to its unique characteristics including collimation and coherence which provide a narrow beam of high light intensity allowing for deep penetration of tissues with great precision of focusing on the target [1][2][3][4]. Considerable applications exploit photothermal effects which induce increased temperature and thus leads to cell or tissue alterations through hyperthermia, coagulation or vaporization processes [4].…”

Section: Introductionmentioning

confidence: 99%

“…Considerable applications exploit photothermal effects which induce increased temperature and thus leads to cell or tissue alterations through hyperthermia, coagulation or vaporization processes [4]. The biggest disadvantage of photothermal therapy (PTT) is the lack of selectivity.…”

Section: Introductionmentioning

confidence: 99%

The potential use of the enhanced nonlinear properties of gold nanospheres in photothermal cancer therapy

et al. 2007

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The energy threshold and selectivity of PTT can greatly benefit from the use of the plasmonic enhanced nonlinear optical processes of spherical gold nanoparticles conjugated to anti-EGFR antibodies. The quadratic dependence of the photothermal efficiency on the pulsed NIR laser power indicates a second harmonic generation or a two photon absorption process. The observed nonlinear dependence on the gold nanoparticle concentration suggests that aggregated nanospheres are responsible for the observed enhanced photothermal destruction of the cells.

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“…56) Basically, photothermal action on tissues results in the following three outcomes: hyperthermia, coagulation, and vaporization. 57) The latter two outcomes necessitate intense heating at >50°C for several seconds, thereby killing cells indiscriminately, whereas hyperthermia can be achieved by more mild heating at 42-49°C for tens of minutes. Therefore, less-invasive photothermal cancer therapy should be based on hyperthermia.…”

Section: Optical Properties Of Swntsmentioning

confidence: 99%

Photodynamic Action of Single-Walled Carbon Nanotubes

Murakami

2017

Chem. Pharm. Bull.

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Photodynamic therapy is achieved by the combination of photosensitizers, harmless visible or nearinfrared (NIR) light, and molecular oxygen (O 2 ). Photosensitizers transfer their absorbed light energy to O 2 to generate a major active species in photodynamic therapy, singlet oxygen. In this review, I will discuss the possibility of single-walled carbon nanotubes as NIR photosensitizers, while explaining the general photophysics and photochemistry underlying photodynamic therapy as well as summarizing recent advances in the purification technologies for single-walled carbon nanotubes to reduce their toxicity concerns.

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Non-PDT Uses of lasers in oncology

Cited by 22 publications

References 15 publications

Gold nanorod assisted near-infrared plasmonic photothermal therapy (PPTT) of squamous cell carcinoma in mice

Gold nanorod assisted near-infrared plasmonic photothermal therapy (PPTT) of squamous cell carcinoma in mice

The potential use of the enhanced nonlinear properties of gold nanospheres in photothermal cancer therapy

Photodynamic Action of Single-Walled Carbon Nanotubes

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