The potential use of the enhanced nonlinear properties of gold nanospheres in photothermal cancer therapy

Abstract

The energy threshold and selectivity of PTT can greatly benefit from the use of the plasmonic enhanced nonlinear optical processes of spherical gold nanoparticles conjugated to anti-EGFR antibodies. The quadratic dependence of the photothermal efficiency on the pulsed NIR laser power indicates a second harmonic generation or a two photon absorption process. The observed nonlinear dependence on the gold nanoparticle concentration suggests that aggregated nanospheres are responsible for the observed enhanced photothermal destruction of the cells.

Multifunctional Nanoplatform for Targeted Laser-induced Hyperthermia and Microscopy of Breast Cancer Cells using SPION-based Gold and Folic Acid Conjugated Nanodendrimers: An in vitro Assay

“…As it is seen, IDAF-Hydr has caused a higher rate of cell death, which is explained by the fact that this formulation with smaller entrapped AuNPs has acted as comparatively stronger heat generating source. These findings are in good agreement with other similar results [68,69].…”

Gold nanorod assisted near-infrared plasmonic photothermal therapy (PPTT) of squamous cell carcinoma in mice

“…By chemically varying the shape or composition of noble metal nanoparticles [9,21,24,[67][68][69], surface plasmon absorption can be tuned from ultraviolet (UV) to infrared (IR) wavelengths. The enhanced nonlinear optical properties of spherical metal nanoparticles have also been used by our group in in vitro near-infrared pulsed laser PPTT by second harmonic generation [29,70,71].…”

Supramolecular nanoscale assemblies for cancer diagnosis and therapy

“…Glazer et al showed in vivo increase in pancreatic cancer cell apoptosis when cetuximab, PAM4-conjugated AuNPs and RF radiation were combined [209]. El-Sayed et al reported that the use of EGFR coated AuNPs increased the photothermal therapy effect by 20 times in human oral squamous cell carcinoma HSC3 cells [210]. Several studies have shown increase in absorption of X-rays by AuNPs internalized in cancer cells [207,211,212].…”