Non-pigmenting fixed drug eruption due to fluoroquinolones

Uncommon variants of fixed drug eruption

“…Erythema dyschromicum perstans-like fixed drug eruption: The patient presents with multiple violaceous plaques with erythematous borders which clinically resemble erythema dyschromicum perstans [Figure 2] 5. Non-pigmenting fixed drug eruption Cotrimoxazole, 10 pseudoephedrine, tetrahydrozoline, piroxicam, thiopental, radio-opaque contrast media (iothalamate), diflunisal, ephedrine, prazinone, sorafenib, tadalafil, esomeprazole, triclofos sodium, betahistine, ibuprofen, 11 acelofenac and fluoroquinolones 12 6. Localised bullous fixed drug eruption Nonsteroidal anti-inflammatory drugs (ibuprofen and mefenamic acid), antibiotics (doxycylline and cotrimoxazole), 13 loxoprofen, mesalazine, levofloxacin, azithromycin, celecoxib, chlorthalidone, etoricoxib, etc.…”

Fixed Drug Eruptions - A Case Series

“…Causality assessments-WHO-Uppsala monitoring centre system. [5,6,9] MANAGEMENT: Implicated offending drug was advised to be avoided.…”

Unusual and interesting adverse cutaneous drug reactions

“…Nonpigmenting FDE has been reported in association with pseudoephedrine,[ 19 ] co-trimoxazole,[ 20 ] tetrahydrozoline, diflunisal, thiopental, piroxicam,[ 21 ] iothalamate, arsephenamine, paracetamol, intra-articular triamcinolone acetonide, eperisone hydrochloride,[ 22 ] furazolidone, and acetaminophen. Recently, reports of nonpigmenting FDE to eprazinone, sorafenib,[ 23 ] tadalafil,[ 24 ] esomeprazole, and fluoroquinolones[ 25 ] have also been described. The lesions can be as large as over 10 cm and multiple lesions possibly represent abortive variant of toxic epidermal necrolysis (TEN).…”